Jump to navigation Jump to search
Slide culture of a Streptomyces sp.
Slide culture of a Streptomyces sp.
Scientific classification
Domain: Bacteria
Phylum: Actinobacteria
Order: Actinomycetales
Family: Streptomycetaceae
Genus: Streptomyces
Waksman & Henrici 1943

S. ambofaciens
S. achromogenes
S. avermitilis
S. coelicolor
S. clavuligerus
S. felleus
S. ferralitis
S. filamentosus
S. griseus
S. hygroscopicus
S. iysosuperficus
S. lividans
S. noursei
S. scabies
S. somaliensis
S. thermoviolaceus
S. violaceoruber
plus ~500 additional species.

WikiDoc Resources for Streptomyces


Most recent articles on Streptomyces

Most cited articles on Streptomyces

Review articles on Streptomyces

Articles on Streptomyces in N Eng J Med, Lancet, BMJ


Powerpoint slides on Streptomyces

Images of Streptomyces

Photos of Streptomyces

Podcasts & MP3s on Streptomyces

Videos on Streptomyces

Evidence Based Medicine

Cochrane Collaboration on Streptomyces

Bandolier on Streptomyces

TRIP on Streptomyces

Clinical Trials

Ongoing Trials on Streptomyces at Clinical

Trial results on Streptomyces

Clinical Trials on Streptomyces at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Streptomyces

NICE Guidance on Streptomyces


FDA on Streptomyces

CDC on Streptomyces


Books on Streptomyces


Streptomyces in the news

Be alerted to news on Streptomyces

News trends on Streptomyces


Blogs on Streptomyces


Definitions of Streptomyces

Patient Resources / Community

Patient resources on Streptomyces

Discussion groups on Streptomyces

Patient Handouts on Streptomyces

Directions to Hospitals Treating Streptomyces

Risk calculators and risk factors for Streptomyces

Healthcare Provider Resources

Symptoms of Streptomyces

Causes & Risk Factors for Streptomyces

Diagnostic studies for Streptomyces

Treatment of Streptomyces

Continuing Medical Education (CME)

CME Programs on Streptomyces


Streptomyces en Espanol

Streptomyces en Francais


Streptomyces in the Marketplace

Patents on Streptomyces

Experimental / Informatics

List of terms related to Streptomyces


Streptomyces, the largest genus of Actinobacteria, is a group of Gram-positive and generally high GC-content bacteria.[1] Streptomycetes are found predominantly in soil and in decaying vegetation, and most produce spores. Streptomycetes are noted for their distinct "earthy" odor which results from production of a volatile metabolite, geosmin.

Streptomycetes are characterised by a complex secondary metabolism.[1] They produce over two thirds of the clinically useful antibiotics of natural origin antibiotics , (Neomycin, Chloramphenicol) to name but a few[2]; the now rarely used streptomycin takes its name directly from Streptomyces. Streptomycetes are infrequent pathogens, though infections in human such as mycetoma can be caused by S. somaliensis and S. sudanensis and in plants such as scabies can be caused by S. caviscabies and S. scabies.


The complete genome of one of the strain, "S. coelicolor" A3(2), was published in 2002.[3] At the time, the "S. coelicolor" genome contained the largest number of genes of any bacterium. The genome sequence of S. avermitilis was completed in 2003.[4] This is the first complete genome sequence of the industrial microorganism. Both of these genomes comprise a single chromosome that is linear, unlike most bacterial genomes which comprise a circular chromosome. The genome sequence of S. scabies, a member of the genus with the ability to cause potato scab disease, has been determined at the Wellcome Trust Sanger Institute and is currently in annotation, with publication scheduled for 2007.

Taxonomically, "S. coelicolor" A3(2) belongs to the species of S. violaceoruber and not a validly described separate species; don't mistake S. coelicolor A3(2) for S. coelicolor (Müller) (ATCC 23899).


In recent years, biotechnology researchers have begun to use Streptomyces spp. for production of recombinant human proteins. Traditionally, Escherichia coli was the species of choice to host eukaryotic genes since it was well understood and easy to work with.[5][6] However, E. coli introduces problems such as incorrect (or lack of) glycosylation and incorrect protein folding, resulting in insolubility and loss of bioactivity of the product.[7] Streptomyces spp. on the other hand have the ability to secrete correctly folded recombinant proteins into the medium after production simplifying the subsequent purification steps. These properties among others make Streptomyces spp. an attractive alternative to other bacteria such as E. coli and Bacillus subtilis.


Streptomyces is the largest antibiotic producing genus ([1]), producing both antibacterials and antifungals, and also a wide range of other bioactive compounds such as immunosuppressants

Some of the antifungals produced by Streptomyces spp.

see also polyene antimycotic

Some of the antibiotics produced by Streptomyces spp.

Some of the anti-cancer compounds produced by Streptomyces spp.


  1. 1.0 1.1 Madigan M; Martinko J (editors). (2005). Brock Biology of Microorganisms (11th ed. ed.). Prentice Hall. ISBN 0-13-144329-1.
  2. Kieser, T., Bibb, M. J., Buttner, M. J., Chater, K. F., and Hopwood, D. A. (2000). Practical Streptomyces Genetics, 2nd edn., Norwich, UK: John Innes Foundation.
  3. Bentley SD; et al. (2002). "Complete genome sequence of the model actinomycete "Streptomyces coelicolor" A3(2)". Nature. 417: 141&ndash, 147. PMID 12000953.
  4. Ikeda H; Ishikawa J; Hanamoto A; Shinose M; Kikuchi H; Shiba T; Sakaki Y; Hattori M; Omura S (2003). "Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis". Nat. Biotechnol. 21: 526&ndash, 531. PMID 12692562.
  5. Brawner M, Poste G, Rosenberg M, Westpheling J (1991). "Streptomyces: a host for heterologous gene expression". Curr Opin Biotechnol. 2 (5): 674–81. PMID 1367716.
  6. Payne G, DelaCruz N, Coppella S (1990). "Improved production of heterologous protein from Streptomyces lividans". Appl Microbiol Biotechnol. 33 (4): 395–400. PMID 1369282.
  7. Binnie C, Cossar J, Stewart D (1997). "Heterologous biopharmaceutical protein expression in Streptomyces". Trends Biotechnol. 15 (8): 315–20. PMID 9263479.

Further reading

  • Baumberg S (1991). Genetics and Product Formation in Streptomyces. Kluwer Academic. ISBN 978-0306438851.
  • Gunsalus IC (1986). Bacteria: Antibiotic-producing Streptomyces. Academic Press. ISBN 978-0123072092.
  • Hopwood DA (2007). Streptomyces in Nature and Medicine: The Antibiotic Makers. Oxford University Press. ISBN 978-0195150667.

See also

  • Antimycin A - compound produced by this bacteria used in piscicides.

External links

Template:Jb1 Template:WH Template:WS