Taxane: Difference between revisions
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Revision as of 19:32, 27 September 2011
WikiDoc Resources for Taxane |
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Ongoing Trials on Taxane at Clinical Trials.gov Clinical Trials on Taxane at Google
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US National Guidelines Clearinghouse on Taxane
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Directions to Hospitals Treating Taxane Risk calculators and risk factors for Taxane
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Overview
The taxanes are diterpenes produced by the plants of the genus Taxus (yews). As their name suggests, they were first derived from natural sources, but some have been synthesized artificially. Taxanes include paclitaxel and docetaxel. Paclitaxel was originally derived from the Pacific yew tree.
Taxanes have been used to produce various chemotherapy drugs. The principal mechanism of the taxane class of drugs is the disruption of microtubule function. It does this by stabilizing GDP-bound tubulin in the microtubule. Microtubules are essential to cell division, and taxanes therefore stop this - a "frozen mitosis". Thus, taxanes are essentially mitotic inhibitors. In contrast to the taxanes, the vinca alkaloids destroy mitotic spindles. Both, taxanes and vinca alkaloids are therefore named spindle poisons or mitosis poisons, but they act in different ways. Taxanes are also thought to be radiosensitizing.