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== Overview ==
== Overview ==
Causes of stomach cancer depend on the type of cancer. Adenocarcinomas are caused by [[genetic]] modulations due to [[chronic inflammation]] mainly by [[Helicobacter pylori|''H. pylori'']] infection. Diffuse gastric carcinomas do not have a [[precancerous]] lesion. [[Somatic]] [[mutations]] in the ''CDH1'' [[gene]] by hypermethylation, [[mutation]], and [[loss of heterozygosity]] are identified in 40 to 83 percent of sporadic diffuse-type gastric cancers. The [[E-cadherin]] [[gene]] (''CDH1'') encodes a [[Transmembrane protein|transmembrane cellular adhesion protein]].
Causes of [[stomach cancer]] depend on the type of [[cancer]]. Adenocarcinomas are caused by [[genetic]] modulations due to [[chronic inflammation]] mainly by [[Helicobacter pylori|''H. pylori'']] infection. Diffuse [[Gastric carcinoma|gastric carcinomas]] do not have a [[precancerous]] lesion. [[Somatic]] [[mutations]] in the ''[[CDH1 (gene)|CDH1]]'' [[gene]] by hypermethylation, [[mutation]], and [[loss of heterozygosity]] are identified in 40 to 83 percent of sporadic diffuse-type [[Gastric cancer|gastric cancers]]. The [[E-cadherin]] [[gene]] (''CDH1'') encodes a [[Transmembrane protein|transmembrane cellular adhesion protein]].


== Stomach cancer causes ==
== Stomach cancer causes ==
Causes of stomach cancer depend upon the type of cancer:
Causes of [[stomach cancer]] depend upon the type of [[cancer]]:<ref name="pmid27722154">{{cite journal |vauthors=Cheng XJ, Lin JC, Tu SP |title=Etiology and Prevention of Gastric Cancer |journal=Gastrointest Tumors |volume=3 |issue=1 |pages=25–36 |date=September 2016 |pmid=27722154 |pmc=5040890 |doi=10.1159/000443995 |url=}}</ref>


==== Adenocarcinoma ====
==== Adenocarcinoma ====
* Adenocarcinomas are caused by [[genetic]] modulations due to [[chronic inflammation]] mainly by H. pylori bacteria.  
* [[Adenocarcinomas]] are caused by [[genetic]] modulations due to [[chronic inflammation]] mainly by [[H. pylori]] [[bacteria]].  
* ''[[Ras oncogene|K-ras]]'' [[Mutations|mutations oncogenes]] are found in [[Invasive (medical)|invasive]] [[Cancer|cancers]] and intestinal [[metaplasia]].  
* ''[[Ras oncogene|K-ras]]'' [[Mutations|mutations oncogenes]] are found in [[Invasive (medical)|invasive]] [[Cancer|cancers]] and [[intestinal]] [[metaplasia]].  
* [[Hepatocyte growth factor]] [[Receptor (biochemistry)|receptor]] c''-met'' [[oncogene]] is found in intestinal-type gastric cancers.  
* [[Hepatocyte growth factor]] [[Receptor (biochemistry)|receptor]] c''-met'' [[oncogene]] is found in intestinal-type [[Gastric cancer|gastric cancers]].  
* Almost 50% of gastric cancers have alterations in [[genes]] ''[[TP53 (gene)|TP53]],'' ''[[TP73L|TP73]]'', ''[[APC]]'', ''TFF'', ''[[DCC1|DCC]]'', ''LOH'', and ''[[FHIT]].''  
* Almost 50% of [[Gastric cancer|gastric cancers]] have alterations in [[genes]] ''[[TP53 (gene)|TP53]],'' ''[[TP73L|TP73]]'', ''[[APC]]'', ''TFF'', ''[[DCC1|DCC]]'', ''LOH'', and ''[[FHIT]].''  
* Inactivation of [[P53 (protein)|p53]] in gastric [[epithelial cells]] reduce their ability to undergo [[apoptosis]].
* Inactivation of [[P53 (protein)|p53]] in [[gastric]] [[epithelial cells]] reduce their ability to undergo [[apoptosis]].


==== Diffuse gastric carcinoma ====
==== Diffuse gastric carcinoma ====
* Diffuse gastric carcinomas do not have a [[precancerous]] lesion.  
* Diffuse [[Gastric carcinoma|gastric carcinomas]] do not have a [[precancerous]] [[lesion]].  


* [[Somatic]] [[mutations]] in the ''CDH1'' [[gene]] by hypermethylation, [[mutation]], and [[loss of heterozygosity]] are identified in 40 to 83 percent of sporadic diffuse-type gastric cancers.  The [[E-cadherin]] [[gene]] (''CDH1'') encodes a [[Transmembrane protein|transmembrane cellular adhesion protein]].
* [[Somatic]] [[mutations]] in the ''CDH1'' [[gene]] by hypermethylation, [[mutation]], and [[loss of heterozygosity]] are identified in 40 to 83 percent of sporadic [[diffuse]]-type [[Gastric cancer|gastric cancers]].  The [[E-cadherin]] [[gene]] (''CDH1'') encodes a [[Transmembrane protein|transmembrane cellular adhesion protein]].
* Prostate [[stem cell]] [[antigen]] [[gene]] is also involved in regulating gastric [[Epithelium|epithelial cell]] [[proliferation]]. Its [[Cytoplasm|cytoplasmic]] tail interacts with [[Catenin|catenins]] making the [[Cell adhesion molecule|adhesion]].
* [[Prostate]] [[stem cell]] [[antigen]] [[gene]] is also involved in regulating [[gastric]] [[Epithelium|epithelial cell]] [[proliferation]]. Its [[Cytoplasm|cytoplasmic]] tail interacts with [[Catenin|catenins]] making the [[Cell adhesion molecule|adhesion]].


==References==
==References==

Revision as of 15:32, 15 January 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohammed Abdelwahed M.D[2]

Overview

Causes of stomach cancer depend on the type of cancer. Adenocarcinomas are caused by genetic modulations due to chronic inflammation mainly by H. pylori infection. Diffuse gastric carcinomas do not have a precancerous lesion. Somatic mutations in the CDH1 gene by hypermethylation, mutation, and loss of heterozygosity are identified in 40 to 83 percent of sporadic diffuse-type gastric cancers. The E-cadherin gene (CDH1) encodes a transmembrane cellular adhesion protein.

Stomach cancer causes

Causes of stomach cancer depend upon the type of cancer:[1]

Adenocarcinoma

Diffuse gastric carcinoma

References

  1. Cheng XJ, Lin JC, Tu SP (September 2016). "Etiology and Prevention of Gastric Cancer". Gastrointest Tumors. 3 (1): 25–36. doi:10.1159/000443995. PMC 5040890. PMID 27722154.

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