Stomach cancer causes

Jump to navigation Jump to search

Stomach cancer Microchapters


Patient Information


Historical Perspective




Differentiating Stomach Cancer from other Diseases

Epidemiology and Demographics

Risk Factors


Natural History, Complications and Prognosis


Diagnostic study of choice


History and Symptoms

Physical Examination

Laboratory Findings

Endoscopy and Biopsy

Chest X Ray



Echocardiography or Ultrasound

Other Imaging Findings

Other Diagnostic Studies


Medical Therapy


Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Stomach cancer causes On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides


American Roentgen Ray Society Images of Stomach cancer causes

All Images
Echo & Ultrasound
CT Images

Ongoing Trials at Clinical

US National Guidelines Clearinghouse

NICE Guidance

FDA on Stomach cancer causes

CDC on Stomach cancer causes

Stomach cancer causes in the news

Blogs on Stomach cancer causes

Directions to Hospitals Treating Stomach cancer

Risk calculators and risk factors for Stomach cancer causes

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Omer Kamal, M.D.[2], Mohammed Abdelwahed M.D[3]


Causes of stomach cancer depend on the type of cancer. Adenocarcinomas are caused by genetic modulations due to chronic inflammation mainly by H. pylori infection. Diffuse gastric carcinomas do not have a precancerous lesion. Somatic mutations in the CDH1 gene by hypermethylation, mutation, and loss of heterozygosity are identified in 40 to 83 percent of sporadic diffuse-type gastric cancers. The E-cadherin gene (CDH1) encodes a transmembrane cellular adhesion protein.

Stomach cancer causes

Causes of stomach cancer depend upon the type of cancer:[1][2][3][4]


Diffuse gastric carcinoma


  1. Cheng XJ, Lin JC, Tu SP (September 2016). "Etiology and Prevention of Gastric Cancer". Gastrointest Tumors. 3 (1): 25–36. doi:10.1159/000443995. PMC 5040890. PMID 27722154.
  2. Correa P (June 2013). "Gastric cancer: overview". Gastroenterol. Clin. North Am. 42 (2): 211–7. doi:10.1016/j.gtc.2013.01.002. PMC 3995345. PMID 23639637.
  3. 3.0 3.1 Corley DA, Kubo A (September 2004). "Influence of site classification on cancer incidence rates: an analysis of gastric cardia carcinomas". J. Natl. Cancer Inst. 96 (18): 1383–7. doi:10.1093/jnci/djh265. PMID 15367571.
  4. 4.0 4.1 Ramos-de la Medina A, More H, Medina-Franco H, Humar B, Gamboa A, Ortiz LJ, Donohue JH, Guilford P (January 2006). "Single nucleotide polymorphisms (SNPs) at CDH1 promoter region in familial gastric cancer". Rev Esp Enferm Dig. 98 (1): 36–41. PMID 16555931.
  5. Ooi CH, Ivanova T, Wu J, Lee M, Tan IB, Tao J, Ward L, Koo JH, Gopalakrishnan V, Zhu Y, Cheng LL, Lee J, Rha SY, Chung HC, Ganesan K, So J, Soo KC, Lim D, Chan WH, Wong WK, Bowtell D, Yeoh KG, Grabsch H, Boussioutas A, Tan P (October 2009). "Oncogenic pathway combinations predict clinical prognosis in gastric cancer". PLoS Genet. 5 (10): e1000676. doi:10.1371/journal.pgen.1000676. PMC 2748685. PMID 19798449.
  6. Graziano F, Humar B, Guilford P (December 2003). "The role of the E-cadherin gene (CDH1) in diffuse gastric cancer susceptibility: from the laboratory to clinical practice". Ann. Oncol. 14 (12): 1705–13. PMID 14630673.

Template:WH Template:WS