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{{Infobox_Disease
| Name          = Sheehan's syndrome
| Image          = Gray1180.png
| Caption        = A pituitary gland anatomy - By Henry Vandyke Carter, Via: Wikimedia.org <ref> Henry Gray (1918) Anatomy of the Human Body, Bartleby.com: Gray's Anatomy, Plate 721, Public Domain, <https://commons.wikimedia.org/w/index.php?curid=541543></ref>
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'''For patient information, click [[Sheehan's syndrome (patient information)|here]]'''
'''For patient information, click [[Sheehan's syndrome (patient information)|here]]'''
{{Sheehan's syndrome}}
{{CMG}}; {{AE}} {{IQ}}
{{SK}} Postpartum pituitary gland necrosis, Postpartum hypopituitarism, Postpartum panhypopituitarism, Postpartum panhypopituitary syndrome.
==[[Sheehan's syndrome overview|Overview]]==
==[[Sheehan's syndrome historical perspective|Historical Perspective]]==
==[[Sheehan's syndrome classification|Classification]]==
==[[Sheehan's syndrome pathophysiology|Pathophysiology]]==
==[[Sheehan's syndrome causes|Causes]]==
==[[Sheehan's syndrome differential diagnosis|Differentiating Sheehan's syndrome  from other Diseases]]==
==[[Sheehan's syndrome epidemiology and demographics|Epidemiology and Demographics]]==


{{Infobox_Disease |
==[[Sheehan's syndrome risk factors|Risk Factors]]==
  Name          = Sheehan syndrome |
  Image          = |
  Caption        = |
  DiseasesDB    = 11998 |
  ICD10          = {{ICD10|E|23|0|e|20}} |
  ICD9          = {{ICD9|253.2}} |
  ICDO          = |
  OMIM          = |
  MedlinePlus    = 001175 |
  eMedicineSubj  = |
  eMedicineTopic = |
  MeshID        = D007018 |
}}
{{Search infobox}}
{{CMG}}


==Overview==
==[[Sheehan's syndrome screening|Screening]]==
'''Sheehan syndrome''', also known as '''postpartum hypopituitarism''' or '''postpartum pituitary necrosis''', is [[hypopituitarism]] (decreased functioning of the [[pituitary gland]]), caused by [[necrosis]] due to [[hemorrhage|blood loss]] and [[hypovolemic shock]] during and after [[childbirth]].


==Causes==
==[[Sheehan's syndrome natural history, complications and prognosis|Natural History, Complications and Prognosis]]==
It is a rare complication of [[pregnancy]], usually occurring after excessive blood loss; the presence of [[disseminated intravascular coagulation]] (e. in [[amniotic fluid embolism]] or [[HELLP syndrome]]) also appears to be a factor in its development.


==Pathophysiology==
==Diagnosis==
Hypertrophy and hyperplasia of [[lactotrophs]] during pregnancy results in the enlargement of the [[anterior pituitary]], without a corresponding increase in blood supply.


Secondly, the anterior pituitary is supplied by a low pressure [[portal venous system]].
[[Sheehan's syndrome history and symptoms|History and Symptoms]] | [[Sheehan's syndrome physical examination|Physical Examination]] | [[Sheehan's syndrome laboratory findings|Laboratory Findings]] | [[Sheehan's syndrome x ray|X Ray]] | [[Sheehan's syndrome CT|CT]] | [[Sheehan's syndrome MRI|MRI]] | [[Sheehan's syndrome echocardiography or ultrasound|Echocardiography or Ultrasound]] | [[Sheehan's syndrome other imaging findings|Other Imaging Findings]] | [[Sheehan's syndrome other diagnostic studies|Other Diagnostic Studies]]


These vulnerabilities, when affected by major [[hemorrhage]] or hypotension during the peripartum period, can result in [[ischaemia]] of the affected pituitary regions leading to [[necrosis]].
==Treatment==


The [[posterior pituitary]] is usually not affected due to its direct arterial supply.
[[Sheehan's syndrome medical therapy|Medical Therapy]] | [[Sheehan's syndrome surgery|Surgery]] | [[Sheehan's syndrome primary prevention|Primary Prevention]] | [[Sheehan's syndrome secondary prevention|Secondary Prevention]] | [[Sheehan's syndrome cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Sheehan's syndrome future or investigational therapies|Future or Investigational Therapies]]


==Eponym==
==Case Studies==
It is named for Harold Sheehan.<ref>{{WhoNamedIt|synd|2009}}</ref><ref>H. L. Sheehan. Post-partum necrosis of anterior pituitary. The Journal of Pathology and Bacteriology, Chichester, 1937, 45: 189-214.</ref>


==References==
[[Sheehan's syndrome case study one|Case #1]]
{{reflist|2}}


{{Endocrine pathology}}
{{Endocrine pathology}}
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{{WikiDoc Sources}}
{{WikiDoc Sources}}


[[Category:Disease]]
 
[[Category:Medicine]]
[[Category:Endocrinology]]
[[Category:Up-To-Date]]
[[Category:Emergency medicine]]
[[Category:Obstetrics]]
[[Category:Obstetrics]]
[[Category:Endocrinology]]

Latest revision as of 00:09, 30 July 2020

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Sheehan's syndrome
A pituitary gland anatomy - By Henry Vandyke Carter, Via: Wikimedia.org [1]

For patient information, click here

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Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Sheehan's syndrome from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Criteria

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

X Ray

CT

MRI

Echocardiography or Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Iqra Qamar M.D.[2]

Synonyms and keywords: Postpartum pituitary gland necrosis, Postpartum hypopituitarism, Postpartum panhypopituitarism, Postpartum panhypopituitary syndrome.

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Sheehan's syndrome from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms | Physical Examination | Laboratory Findings | X Ray | CT | MRI | Echocardiography or Ultrasound | Other Imaging Findings | Other Diagnostic Studies

Treatment

Medical Therapy | Surgery | Primary Prevention | Secondary Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies

Case Studies

Case #1

de:Sheehan-Syndrom it:Sindrome di Sheehan


Template:WikiDoc Sources

  1. Henry Gray (1918) Anatomy of the Human Body, Bartleby.com: Gray's Anatomy, Plate 721, Public Domain, <https://commons.wikimedia.org/w/index.php?curid=541543>