Sheehan's syndrome diagnostic criteria
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Iqra Qamar M.D.[2]
Overview
Diagnosis of Sheehan's syndrome is made on clinical basis with a recent/remote history of traumatic delivery or delivery complicated by hypotension.
Diagnostic Criteria
- There is no specific established diagnostic criteria for Sheehan's syndrome.
- Diagnosis of Sheehan's syndrome is made on clinical basis with a recent/remote history of traumatic delivery or delivery complicated by hypotension.
- Diagnosis is mostly clinical but following steps are required to make the diagnosis of Sheehan's syndrome:
- Detailed medical history
- Measurement of pituitary hormone levels in blood
- Pituitary hormone stimulation tests:[1][2]
- Insulin tolerance
- chlorpromazine
- metoclopramide
- Comiphene citrate stimulation tests
- Imaging (MRI preferred on CT)
References
- ↑ Cunningham SK, Moore A, McKenna TJ (1983). "Normal cortisol response to corticotropin in patients with secondary adrenal failure". Arch. Intern. Med. 143 (12): 2276–9. PMID 6316866.
- ↑ Grinspoon SK, Biller BM (1994). "Clinical review 62: Laboratory assessment of adrenal insufficiency". J. Clin. Endocrinol. Metab. 79 (4): 923–31. doi:10.1210/jcem.79.4.7962298. PMID 7962298.