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{{Sexcord/ stromal ovarian tumors}}
{{Sexcord/ stromal ovarian tumors}}


{{CMG}}; {{AE}}  
{{CMG}}; {{AE}} {{M.N}}
==Overview==
==Overview==
There is no established system for the classification of [disease name].


OR
Sexcord/ stromal ovarian tumors may be classified according to [[WHO]] into 3 subtypes: pure stromal tumors, pure sexcord tumors, mixed stromal and sexcord tumors. [[Histological]] [[classification]] of sexcord-stromal ovarian tumors includes [[granulosa]] stromal cell tumors, [[Sertoli-Leydig cell tumour|sertoli leydig cell tumors]], gynandroblastoma, and unclassified.
 
[Disease name] may be classified according to [classification method] into [number] subtypes/groups: [group1], [group2], [group3], and [group4].
 
OR
 
[Disease name] may be classified into [large number > 6] subtypes based on [classification method 1], [classification method 2], and [classification method 3].
[Disease name] may be classified into several subtypes based on [classification method 1], [classification method 2], and [classification method 3].
 
OR
 
Based on the duration of symptoms, [disease name] may be classified as either acute or chronic.
 
OR
 
If the staging system involves specific and characteristic findings and features:
According to the [staging system + reference], there are [number] stages of [malignancy name] based on the [finding1], [finding2], and [finding3]. Each stage is assigned a [letter/number1] and a [letter/number2] that designate the [feature1] and [feature2].
 
OR
 
The staging of [malignancy name] is based on the [staging system].
 
OR
 
There is no established system for the staging of [malignancy name].


==Classification==
==Classification==
'''WHO''' classification for ovarian sex cord-stromal tumors:<ref name="pmid26054417">{{cite journal |vauthors=Horta M, Cunha TM |title=Sex cord-stromal tumors of the ovary: a comprehensive review and update for radiologists |journal=Diagn Interv Radiol |volume=21 |issue=4 |pages=277–86 |date=2015 |pmid=26054417 |pmc=4498422 |doi=10.5152/dir.2015.34414 |url=}}</ref><ref name="pmid26894303">{{cite journal |vauthors=Meinhold-Heerlein I, Fotopoulou C, Harter P, Kurzeder C, Mustea A, Wimberger P, Hauptmann S, Sehouli J |title=The new WHO classification of ovarian, fallopian tube, and primary peritoneal cancer and its clinical implications |journal=Arch. Gynecol. Obstet. |volume=293 |issue=4 |pages=695–700 |date=April 2016 |pmid=26894303 |doi=10.1007/s00404-016-4035-8 |url=}}</ref><ref name="pmid26556905">{{cite journal |vauthors=Meinhold-Heerlein I, Fotopoulou C, Harter P, Kurzeder C, Mustea A, Wimberger P, Hauptmann S, Sehouli J |title=Statement by the Kommission Ovar of the AGO: The New FIGO and WHO Classifications of Ovarian, Fallopian Tube and Primary Peritoneal Cancer |journal=Geburtshilfe Frauenheilkd |volume=75 |issue=10 |pages=1021–1027 |date=October 2015 |pmid=26556905 |pmc=4629993 |doi=10.1055/s-0035-1558079 |url=}}</ref><ref name="pmid21716157">{{cite journal |vauthors=McCluggage WG |title=Morphological subtypes of ovarian carcinoma: a review with emphasis on new developments and pathogenesis |journal=Pathology |volume=43 |issue=5 |pages=420–32 |date=August 2011 |pmid=21716157 |doi=10.1097/PAT.0b013e328348a6e7 |url=}}</ref>
'''WHO classification for ovarian sex cord-stromal tumors''':<ref name="pmid26054417">{{cite journal |vauthors=Horta M, Cunha TM |title=Sex cord-stromal tumors of the ovary: a comprehensive review and update for radiologists |journal=Diagn Interv Radiol |volume=21 |issue=4 |pages=277–86 |date=2015 |pmid=26054417 |pmc=4498422 |doi=10.5152/dir.2015.34414 |url=}}</ref><ref name="pmid26894303">{{cite journal |vauthors=Meinhold-Heerlein I, Fotopoulou C, Harter P, Kurzeder C, Mustea A, Wimberger P, Hauptmann S, Sehouli J |title=The new WHO classification of ovarian, fallopian tube, and primary peritoneal cancer and its clinical implications |journal=Arch. Gynecol. Obstet. |volume=293 |issue=4 |pages=695–700 |date=April 2016 |pmid=26894303 |doi=10.1007/s00404-016-4035-8 |url=}}</ref><ref name="pmid26556905">{{cite journal |vauthors=Meinhold-Heerlein I, Fotopoulou C, Harter P, Kurzeder C, Mustea A, Wimberger P, Hauptmann S, Sehouli J |title=Statement by the Kommission Ovar of the AGO: The New FIGO and WHO Classifications of Ovarian, Fallopian Tube and Primary Peritoneal Cancer |journal=Geburtshilfe Frauenheilkd |volume=75 |issue=10 |pages=1021–1027 |date=October 2015 |pmid=26556905 |pmc=4629993 |doi=10.1055/s-0035-1558079 |url=}}</ref><ref name="pmid21716157">{{cite journal |vauthors=McCluggage WG |title=Morphological subtypes of ovarian carcinoma: a review with emphasis on new developments and pathogenesis |journal=Pathology |volume=43 |issue=5 |pages=420–32 |date=August 2011 |pmid=21716157 |doi=10.1097/PAT.0b013e328348a6e7 |url=}}</ref><ref name="ChenRuiz2003">{{cite journal|last1=Chen|first1=Vivien W.|last2=Ruiz|first2=Bernardo|last3=Killeen|first3=Jeffrey L.|last4=Cot�|first4=Timothy R.|last5=Wu|first5=Xiao Cheng|last6=Correa|first6=Catherine N.|last7=Howe|first7=Holly L.|title=Pathology and classification of ovarian tumors|journal=Cancer|volume=97|issue=S10|year=2003|pages=2631–2642|issn=0008-543X|doi=10.1002/cncr.11345}}</ref>
 
*'''Pure stromal tumors'''
*'''Pure stromal tumors'''
** Fibroma
** [[Fibroma]]
** Cellular fibroma
** [[Cellular]] [[fibroma]]
**Thecoma
**[[Thecoma]]
** Luteinized thecoma associated with sclerosing peritonitis
** Luteinized [[thecoma]] associated with sclerosing [[peritonitis]]
** Fibrosarcoma
** [[Fibrosarcoma]]
** Sclerosing stromal tumor
** Sclerosing [[stromal]] [[tumor]]
** Signet-ring stromal tumor
** [[Signet ring|Signet-ring]] [[stromal]] [[tumor]]
** Microcystic stromal tumor
**<nowiki/>[[Microcytic|Microcy]]<nowiki/>stic [[stromal]] [[tumor]]
** Leydig cell tumor
** [[Leydig cell tumor|Leydig]] <nowiki/>[[Leydig cell tumor|cell tumor]]
** Steroid cell tumor
** Steroid cell tumor
** Steroid cell tumor, malignant
** Steroid cell tumor, [[malignant]]
*'''Pure sex cord tumors'''
*'''Pure sex cord tumors'''
** Adult granulosa cell tumor
** [[Granulosa cell tumor|Adult granulosa cell tumor]]
**Juvenile granulosa cell tumor
**Juvenile [[granulosa cell tumor]]
** Sertoli cell tumor
** Sertoli cell tumor
** Sex cord tumor with annular tubules
** Sex cord tumor with annular tubules
*'''Mixed sex cord-stromal tumors'''
*'''Mixed sex cord-stromal tumors'''
**Sertoli-Leydig cell tumors
**[[Sertoli-Leydig cell tumour|Sertoli-Leydig cell tumors]]
***Well-differentiated
***Well-differentiated
***Moderately differentiated with heterologous elements
***Moderately differentiated with heterologous elements
Line 59: Line 33:
**Sex cord-stromal tumours, NOS
**Sex cord-stromal tumours, NOS
{| class="wikitable"
{| class="wikitable"
|+WHO classification scheme for ovarian sex cord-stromal tumors<ref name="pmid26054417">{{cite journal |vauthors=Horta M, Cunha TM |title=Sex cord-stromal tumors of the ovary: a comprehensive review and update for radiologists |journal=Diagn Interv Radiol |volume=21 |issue=4 |pages=277–86 |date=2015 |pmid=26054417 |pmc=4498422 |doi=10.5152/dir.2015.34414 |url=}}</ref><ref name="pmid26894303">{{cite journal |vauthors=Meinhold-Heerlein I, Fotopoulou C, Harter P, Kurzeder C, Mustea A, Wimberger P, Hauptmann S, Sehouli J |title=The new WHO classification of ovarian, fallopian tube, and primary peritoneal cancer and its clinical implications |journal=Arch. Gynecol. Obstet. |volume=293 |issue=4 |pages=695–700 |date=April 2016 |pmid=26894303 |doi=10.1007/s00404-016-4035-8 |url=}}</ref><ref name="pmid26556905">{{cite journal |vauthors=Meinhold-Heerlein I, Fotopoulou C, Harter P, Kurzeder C, Mustea A, Wimberger P, Hauptmann S, Sehouli J |title=Statement by the Kommission Ovar of the AGO: The New FIGO and WHO Classifications of Ovarian, Fallopian Tube and Primary Peritoneal Cancer |journal=Geburtshilfe Frauenheilkd |volume=75 |issue=10 |pages=1021–1027 |date=October 2015 |pmid=26556905 |pmc=4629993 |doi=10.1055/s-0035-1558079 |url=}}</ref>
|+WHO classification scheme for ovarian sex cord-stromal tumors<ref name="pmid26054417">{{cite journal |vauthors=Horta M, Cunha TM |title=Sex cord-stromal tumors of the ovary: a comprehensive review and update for radiologists |journal=Diagn Interv Radiol |volume=21 |issue=4 |pages=277–86 |date=2015 |pmid=26054417 |pmc=4498422 |doi=10.5152/dir.2015.34414 |url=}}</ref><ref name="pmid26894303">{{cite journal |vauthors=Meinhold-Heerlein I, Fotopoulou C, Harter P, Kurzeder C, Mustea A, Wimberger P, Hauptmann S, Sehouli J |title=The new WHO classification of ovarian, fallopian tube, and primary peritoneal cancer and its clinical implications |journal=Arch. Gynecol. Obstet. |volume=293 |issue=4 |pages=695–700 |date=April 2016 |pmid=26894303 |doi=10.1007/s00404-016-4035-8 |url=}}</ref><ref name="pmid26556905">{{cite journal |vauthors=Meinhold-Heerlein I, Fotopoulou C, Harter P, Kurzeder C, Mustea A, Wimberger P, Hauptmann S, Sehouli J |title=Statement by the Kommission Ovar of the AGO: The New FIGO and WHO Classifications of Ovarian, Fallopian Tube and Primary Peritoneal Cancer |journal=Geburtshilfe Frauenheilkd |volume=75 |issue=10 |pages=1021–1027 |date=October 2015 |pmid=26556905 |pmc=4629993 |doi=10.1055/s-0035-1558079 |url=}}</ref><ref name="pmid21716157">{{cite journal |vauthors=McCluggage WG |title=Morphological subtypes of ovarian carcinoma: a review with emphasis on new developments and pathogenesis |journal=Pathology |volume=43 |issue=5 |pages=420–32 |date=August 2011 |pmid=21716157 |doi=10.1097/PAT.0b013e328348a6e7 |url=}}</ref><ref name="ChenRuiz2003">{{cite journal|last1=Chen|first1=Vivien W.|last2=Ruiz|first2=Bernardo|last3=Killeen|first3=Jeffrey L.|last4=Cot�|first4=Timothy R.|last5=Wu|first5=Xiao Cheng|last6=Correa|first6=Catherine N.|last7=Howe|first7=Holly L.|title=Pathology and classification of ovarian tumors|journal=Cancer|volume=97|issue=S10|year=2003|pages=2631–2642|issn=0008-543X|doi=10.1002/cncr.11345}}</ref>
 
| align="center" style="background: #4479BA;" | {{fontcolor|#FFF|'''Types'''}}
| align="center" style="background: #4479BA;" | {{fontcolor|#FFF|'''Types'''}}
| align="center" style="background: #4479BA;" | {{fontcolor|#FFF|'''Subtypes'''}}
| align="center" style="background: #4479BA;" | {{fontcolor|#FFF|'''Subtypes'''}}
Line 65: Line 40:
|'''Pure stromal tumors'''
|'''Pure stromal tumors'''
|
|
* Fibroma
* [[Fibroma]]
* Cellular fibroma
* [[Cellular]] [[fibroma]]
* Thecoma
* [[Thecoma]]
* Luteinized thecoma associated with sclerosing peritonitis
* Luteinized [[thecoma]] associated with sclerosing peritonitis
* Fibrosarcoma
* [[Fibrosarcoma]]
* Sclerosing stromal tumor
* Sclerosing stromal tumor
* Signet-ring stromal tumor
* Signet-ring stromal tumor
* Microcystic stromal tumor
* Microcystic stromal tumor
* Leydig cell tumor
* [[Leydig cell tumor]]
* Steroid cell tumor
* Steroid cell tumor
* Steroid cell tumor, malignant
* Steroid cell tumor, [[malignant]]
|-
|-
|'''Pure sex cord tumors'''
|'''Pure sex cord tumors'''
|
|
* Adult granulosa cell tumor
* [[Granulosa cell tumor|Adult granulosa cell tumor]]
* Juvenile granulosa cell tumor
* [[Granulosa cell tumor|Juvenile granulosa cell tumor]]
* Sertoli cell tumor
* [[Sertoli Cell Tumor|Sertoli cell tumor]]
* Sex cord tumor with annular tubules
* Sex cord tumor with annular [[tubules]]
|-
|-
|'''Mixed sex cord-stromal tumors'''
|'''Mixed sex cord-stromal tumors'''
|
|
* Sertoli-Leydig cell tumors
* [[Sertoli-Leydig cell tumour|Sertoli-Leydig cell tumors]]
** Well-differentiated
** Well-differentiated
** Moderately differentiated with heterologous elements
** Moderately differentiated with heterologous elements
Line 92: Line 67:
** Retiform with heterologous elements
** Retiform with heterologous elements
* Sex cord-stromal tumours, NOS
* Sex cord-stromal tumours, NOS
|-
| colspan="2" |NOS, not otherwise specified
|}
{| class="wikitable"
|+'''Histological classification of ovarian sex cord‐stromal tumors'''<ref name="FullerLeung2017">{{cite journal|last1=Fuller|first1=P.J.|last2=Leung|first2=D.|last3=Chu|first3=S.|title=Genetics and genomics of ovarian sex cord-stromal tumors|journal=Clinical Genetics|volume=91|issue=2|year=2017|pages=285–291|issn=00099163|doi=10.1111/cge.12917}}</ref>
| align="center" style="background: #4479BA;" | {{fontcolor|#FFF|'''Types'''}}
| align="center" style="background: #4479BA;" | {{fontcolor|#FFF|'''Subtypes'''}}
|-
|'''Granulosa‐stromal cell tumors'''
|
*[[Granulosa cell tumor]]
*[[Tumors]] in the [[thecoma]]‐[[fibroma]] group
**[[Thecoma]]
**[[Fibroma]]
**Unclassified
|-
|'''Sertoli–Leydig cell tumors'''
|
*Well‐differentiated
**[[Sertoli Cell Tumor|Sertoli cell tumor]]
**[[Sertoli Cell Tumor|Sertoli cell tumor]] with [[lipid]] storage
**[[Sertoli-Leydig cell tumour|Sertoli–Leydig cell tumor]] (tubular adenoma with [[Leydig cells]])
*Of intermediate differentiation
*Poorly differentiated (sarcomatoid)
*With heterologous elements
|-
|'''Gynandroblastoma'''
|No specific subtypes
|-
|'''Unclassified'''
|No specific subtypes
|}
'''International Agency for Research on Cancer Histologic Groups of Ovarian Tumors'''
Classification from '''International agency for research on cancer''' is summarized in the table: <ref name="pmid26894303">{{cite journal |vauthors=Meinhold-Heerlein I, Fotopoulou C, Harter P, Kurzeder C, Mustea A, Wimberger P, Hauptmann S, Sehouli J |title=The new WHO classification of ovarian, fallopian tube, and primary peritoneal cancer and its clinical implications |journal=Arch. Gynecol. Obstet. |volume=293 |issue=4 |pages=695–700 |date=April 2016 |pmid=26894303 |doi=10.1007/s00404-016-4035-8 |url=}}</ref><ref name="urlonlinelibrary.wiley.com">{{cite web |url=https://onlinelibrary.wiley.com/doi/pdf/10.1002/cncr.11345 |title=onlinelibrary.wiley.com |format= |work= |accessdate=}}</ref><ref name="pmid26556905">{{cite journal |vauthors=Meinhold-Heerlein I, Fotopoulou C, Harter P, Kurzeder C, Mustea A, Wimberger P, Hauptmann S, Sehouli J |title=Statement by the Kommission Ovar of the AGO: The New FIGO and WHO Classifications of Ovarian, Fallopian Tube and Primary Peritoneal Cancer |journal=Geburtshilfe Frauenheilkd |volume=75 |issue=10 |pages=1021–1027 |date=October 2015 |pmid=26556905 |pmc=4629993 |doi=10.1055/s-0035-1558079 |url=}}</ref>
{| class="wikitable"
|+
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Ovarian tumors
|-
|
* [[Carcinoma]]
** [[Serous]] [[carcinoma]]
** [[Mucinous carcinoma]]
** [[Endometrial cancer|Endometrioid carcinoma]]
** [[Clear cell endometrial cancer|Clear cell carcinoma]]
** Adenocarcinoma NOS
** Other specified carcinomas
** Unspecified carcinoma
* Sex cord-stromal tumors
* [[Germ cell tumors]]
* Other specified cancers (including malignant [[Brenner tumor of ovary|Brenner tumor]], mullerian mixed tumor, and carcinosarcoma)
* Unspecified cancer
|}
|}
NOS, not otherwise specified.


==References==
==References==
{{Reflist|2}}
{{Reflist|2}}
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Latest revision as of 17:24, 29 May 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Maneesha Nandimandalam, M.B.B.S.[2]

Overview

Sexcord/ stromal ovarian tumors may be classified according to WHO into 3 subtypes: pure stromal tumors, pure sexcord tumors, mixed stromal and sexcord tumors. Histological classification of sexcord-stromal ovarian tumors includes granulosa stromal cell tumors, sertoli leydig cell tumors, gynandroblastoma, and unclassified.

Classification

WHO classification for ovarian sex cord-stromal tumors:[1][2][3][4][5]

WHO classification scheme for ovarian sex cord-stromal tumors[1][2][3][4][5]
Types Subtypes
Pure stromal tumors
Pure sex cord tumors
Mixed sex cord-stromal tumors
  • Sertoli-Leydig cell tumors
    • Well-differentiated
    • Moderately differentiated with heterologous elements
    • Poorly differentiated with heterologous elements
    • Retiform with heterologous elements
  • Sex cord-stromal tumours, NOS
NOS, not otherwise specified
Histological classification of ovarian sex cord‐stromal tumors[6]
Types Subtypes
Granulosa‐stromal cell tumors
Sertoli–Leydig cell tumors
Gynandroblastoma No specific subtypes
Unclassified No specific subtypes

International Agency for Research on Cancer Histologic Groups of Ovarian Tumors

Classification from International agency for research on cancer is summarized in the table: [2][7][3]

Ovarian tumors

References

  1. ↑ 1.0 1.1 Horta M, Cunha TM (2015). "Sex cord-stromal tumors of the ovary: a comprehensive review and update for radiologists". Diagn Interv Radiol. 21 (4): 277–86. doi:10.5152/dir.2015.34414. PMC 4498422. PMID 26054417.
  2. ↑ 2.0 2.1 2.2 Meinhold-Heerlein I, Fotopoulou C, Harter P, Kurzeder C, Mustea A, Wimberger P, Hauptmann S, Sehouli J (April 2016). "The new WHO classification of ovarian, fallopian tube, and primary peritoneal cancer and its clinical implications". Arch. Gynecol. Obstet. 293 (4): 695–700. doi:10.1007/s00404-016-4035-8. PMID 26894303.
  3. ↑ 3.0 3.1 3.2 Meinhold-Heerlein I, Fotopoulou C, Harter P, Kurzeder C, Mustea A, Wimberger P, Hauptmann S, Sehouli J (October 2015). "Statement by the Kommission Ovar of the AGO: The New FIGO and WHO Classifications of Ovarian, Fallopian Tube and Primary Peritoneal Cancer". Geburtshilfe Frauenheilkd. 75 (10): 1021–1027. doi:10.1055/s-0035-1558079. PMC 4629993. PMID 26556905.
  4. ↑ 4.0 4.1 McCluggage WG (August 2011). "Morphological subtypes of ovarian carcinoma: a review with emphasis on new developments and pathogenesis". Pathology. 43 (5): 420–32. doi:10.1097/PAT.0b013e328348a6e7. PMID 21716157.
  5. ↑ 5.0 5.1 Chen, Vivien W.; Ruiz, Bernardo; Killeen, Jeffrey L.; Cot�, Timothy R.; Wu, Xiao Cheng; Correa, Catherine N.; Howe, Holly L. (2003). "Pathology and classification of ovarian tumors". Cancer. 97 (S10): 2631–2642. doi:10.1002/cncr.11345. ISSN 0008-543X. replacement character in |last4= at position 4 (help)
  6. ↑ Fuller, P.J.; Leung, D.; Chu, S. (2017). "Genetics and genomics of ovarian sex cord-stromal tumors". Clinical Genetics. 91 (2): 285–291. doi:10.1111/cge.12917. ISSN 0009-9163.
  7. ↑ "onlinelibrary.wiley.com".

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