Sexcord/ stromal ovarian tumors natural history, complications and prognosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: ; Maneesha Nandimandalam, M.B.B.S.[2]
Overview
The symtoms of sexcord/ stromal ovarian tumors include Adnexal mass, Abdominal & pelvic symptoms, Bloating, Urinary urgency or frequency, Dysphagia(difficulty)eating) or feeling full quickly, Pelvic or abdominal pain. Common complications of sexcord/ stromal ovarian tumors include malignant pleural effusion,bowel obstruction,ascites. The prognosis varies with the subtypes of tumor. Most sexcord-stromal ovarian tumors present at a low tumor stage and also prognosis in these patients is excellent.
Natural History, Complications, and Prognosis
Natural History
- The symptoms of sexcord/ stromal ovarian tumors usually develop in the second/ third/ fourth decade of life, and start with symptoms such as:[1]
- Adnexal mass
- Abdominal & pelvic symptoms
- Bloating
- Urinary urgency or frequency
- Dysphagia(difficulty eating) or feeling full quickly
- Pelvic or abdominal pain
Complications
- Common complications of sexcord/ stromal ovarian tumors include:
Prognosis
- Depending on the extent of the tumor at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as excellent[2][3][4][5][3][6]
- The prognosis varies with the subtypes of tumor
- Most sexcord-stromal ovarian tumors present at a low tumor stage and also prognosis in these patients is excellent
- The two important predictors for improved survival in patients with ovarian sex cord stromal tumors are young age and early-stage disease
- Patients with juvinile granulosa cell tumors(JGCT) and sertoli-Leydig cell tumors (SLCTs) show greater mitotic activity than all other histologic types
- The presence of greater mitotic activity is associated with a particularly poor prognosis among patients with juvinile granulosa cell tumors(JGCT) and sertoli-Leydig cell tumors (SLCTs)
- Other independent prognostic factors in adult granulosa cell tumors include mitotic index, lymphovascular invasion, cellular atypia, and absence of Call-Exner bodies
- Sertoli-Leydig cell tumors have a 70 to 90 percent five-year survival overall and is mainly related to the stage and degree of histologic differentiation
References
- ↑ Ayhan A, Salman MC, Velipasaoglu M, Sakinci M, Yuce K (September 2009). "Prognostic factors in adult granulosa cell tumors of the ovary: a retrospective analysis of 80 cases". J Gynecol Oncol. 20 (3): 158–63. doi:10.3802/jgo.2009.20.3.158. PMID 19809549.
- ↑ Schneider DT, Calaminus G, Harms D, Göbel U (June 2005). "Ovarian sex cord-stromal tumors in children and adolescents". J Reprod Med. 50 (6): 439–46. PMID 16050568.
- ↑ 3.0 3.1 Elashry R, Hemida R, Goda H, Abdel-Hady e (2013). "Prognostic factors of germ cell and sex cord-stromal ovarian tumors in pediatric age: 5 years experience". J. Exp. Ther. Oncol. 10 (3): 181–7. PMID 24416992. Vancouver style error: initials (help)
- ↑ Zanagnolo V, Pasinetti B, Sartori E (2004). "Clinical review of 63 cases of sex cord stromal tumors". Eur. J. Gynaecol. Oncol. 25 (4): 431–8. PMID 15285297.
- ↑ Zhang, Mallory; Cheung, Michael K.; Shin, Jacob Y.; Kapp, Daniel S.; Husain, Amreen; Teng, Nelson N.; Berek, Jonathan S.; Osann, Kathryn; Chan, John K. (2007). "Prognostic factors responsible for survival in sex cord stromal tumors of the ovary—An analysis of 376 women". Gynecologic Oncology. 104 (2): 396–400. doi:10.1016/j.ygyno.2006.08.032. ISSN 0090-8258.
- ↑ Wang J, Li J, Chen R, Lu X (July 2018). "Contribution of lymph node staging method and prognostic factors in malignant ovarian sex cord-stromal tumors: A world wide database analysis". Eur J Surg Oncol. 44 (7): 1054–1061. doi:10.1016/j.ejso.2018.03.027. PMID 29705285.