SPI1: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{reflist}} +{{reflist|2}}, -<references /> +{{reflist|2}}, -{{WikiDoc Cardiology Network Infobox}} +))
 
m (Bot: HTTP→HTTPS)
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}} __NOTOC__
{{PBB_Controls
'''Transcription factor PU.1''' is a [[protein]] that in humans is encoded by the ''SPI1'' [[gene]].<ref name="pmid1693183">{{cite journal | vauthors = Ray D, Culine S, Tavitain A, Moreau-Gachelin F | title = The human homologue of the putative proto-oncogene Spi-1: characterization and expression in tumors | journal = Oncogene | volume = 5 | issue = 5 | pages = 663–8 | date = July 1990 | pmid = 1693183 | pmc = | doi = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_SPI1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1pue.
| PDB = {{PDB2|1pue}}
| Name = Spleen focus forming virus (SFFV) proviral integration oncogene spi1
| HGNCid = 11241
| Symbol = SPI1
| AltSymbols =; OF; PU.1; SFPI1; SPI-1; SPI-A
| OMIM = 165170
| ECnumber = 
| Homologene = 2346
| MGIid = 98282
| GeneAtlas_image1 = PBB_GE_SPI1_205312_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016563 |text = transcription activator activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0000122 |text = negative regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0030098 |text = lymphocyte differentiation}} {{GNF_GO|id=GO:0030225 |text = macrophage differentiation}} {{GNF_GO|id=GO:0030851 |text = granulocyte differentiation}} {{GNF_GO|id=GO:0045893 |text = positive regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6688
    | Hs_Ensembl = ENSG00000066336
    | Hs_RefseqProtein = NP_001074016
    | Hs_RefseqmRNA = NM_001080547
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 47332988
    | Hs_GenLoc_end = 47356674
    | Hs_Uniprot = P17947
    | Mm_EntrezGene = 20375
    | Mm_Ensembl = ENSMUSG00000002111
    | Mm_RefseqmRNA = XM_001003437
    | Mm_RefseqProtein = XP_001003437
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 90897636
    | Mm_GenLoc_end = 90916595
    | Mm_Uniprot = Q3U5L4
  }}
}}
'''Spleen focus forming virus (SFFV) proviral integration oncogene spi1''', also known as '''SPI1''', is a human [[gene]].


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development{{Citation needed|date=July 2017}}. The nuclear protein binds to a purine-rich sequence known as the PU-box found near the promoters of target genes, and regulates their expression in coordination with other transcription factors and cofactors. The protein can also regulate alternative splicing of target genes. Multiple transcript variants encoding different isoforms have been found for this gene.<ref>{{cite web | title = Entrez Gene: SPI1 spleen focus forming virus (SFFV) proviral integration oncogene spi1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6688| accessdate = }}</ref>
{{PBB_Summary
| section_title =
| summary_text = This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development. The nuclear protein binds to a purine-rich sequence known as the PU-box found near the promoters of target genes, and regulates their expression in coordination with other transcription factors and cofactors. The protein can also regulate alternative splicing of target genes. Multiple transcript variants encoding different isoforms have been found for this gene.<ref>{{cite web | title = Entrez Gene: SPI1 spleen focus forming virus (SFFV) proviral integration oncogene spi1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6688| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
SPI1 has been shown to [[Protein-protein interaction|interact]] with:
* [[FUS (gene)|FUS]],<ref name = pmid9478924>{{cite journal | vauthors = Hallier M, Lerga A, Barnache S, Tavitian A, Moreau-Gachelin F | title = The transcription factor Spi-1/PU.1 interacts with the potential splicing factor TLS | journal = J. Biol. Chem. | volume = 273 | issue = 9 | pages = 4838–42 | date = February 1998 | pmid = 9478924 | doi =  10.1074/jbc.273.9.4838}}</ref>
* [[GATA2]],<ref name = pmid10411939>{{cite journal | vauthors = Zhang P, Behre G, Pan J, Iwama A, Wara-Aswapati N, Radomska HS, Auron PE, Tenen DG, Sun Z | title = Negative cross-talk between hematopoietic regulators: GATA proteins repress PU.1 | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 96 | issue = 15 | pages = 8705–10 | date = July 1999 | pmid = 10411939 | pmc = 17580 | doi =  10.1073/pnas.96.15.8705}}</ref>
* [[IRF4]],<ref name = pmid10022840>{{cite journal | vauthors = Brass AL, Zhu AQ, Singh H | title = Assembly requirements of PU.1-Pip (IRF-4) activator complexes: inhibiting function in vivo using fused dimers | journal = EMBO J. | volume = 18 | issue = 4 | pages = 977–91 | date = February 1999 | pmid = 10022840 | pmc = 1171190 | doi = 10.1093/emboj/18.4.977 }}</ref><ref name = pmid12372320>{{cite journal | vauthors = Escalante CR, Shen L, Escalante MC, Brass AL, Edwards TA, Singh H, Aggarwal AK | title = Crystallization and characterization of PU.1/IRF-4/DNA ternary complex | journal = J. Struct. Biol. | volume = 139 | issue = 1 | pages = 55–9 | date = July 2002 | pmid = 12372320 | doi =  10.1016/s1047-8477(02)00514-2}}</ref> and
* [[NONO]].<ref name = pmid8626664>{{cite journal | vauthors = Hallier M, Tavitian A, Moreau-Gachelin F | title = The transcription factor Spi-1/PU.1 binds RNA and interferes with the RNA-binding protein p54nrb | journal = J. Biol. Chem. | volume = 271 | issue = 19 | pages = 11177–81 | date = May 1996 | pmid = 8626664 | doi =  10.1074/jbc.271.19.11177}}</ref>
 
== See also ==
*[[Spi-1 (PU.1) 5' UTR regulatory element]]
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Klemsz MJ, McKercher SR, Celada A, Van Beveren C, Maki RA | title = The macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogene. | journal = Cell | volume = 61 | issue = 1 | pages = 113–24 | year = 1990 | pmid = 2180582 | doi = 10.1016/0092-8674(90)90219-5 }}
| citations =
* {{cite journal | vauthors = Nguyen VC, Ray D, Gross MS, de Tand MF, Frézal J, Moreau-Gachelin F | title = Localization of the human oncogene SPI1 on chromosome 11, region p11.22. | journal = Hum. Genet. | volume = 84 | issue = 6 | pages = 542–6 | year = 1990 | pmid = 2338340 | doi = 10.1007/bf00210807 }}
*{{cite journal | author=Ray D, Culine S, Tavitain A, Moreau-Gachelin F |title=The human homologue of the putative proto-oncogene Spi-1: characterization and expression in tumors. |journal=Oncogene |volume=5 |issue= 5 |pages= 663-8 |year= 1990 |pmid= 1693183 |doi= }}
* {{cite journal | vauthors = Chen H, Ray-Gallet D, Zhang P, Hetherington CJ, Gonzalez DA, Zhang DE, Moreau-Gachelin F, Tenen DG | title = PU.1 (Spi-1) autoregulates its expression in myeloid cells. | journal = Oncogene | volume = 11 | issue = 8 | pages = 1549–60 | year = 1995 | pmid = 7478579 | doi =  }}
*{{cite journal | author=Klemsz MJ, McKercher SR, Celada A, ''et al.'' |title=The macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogene. |journal=Cell |volume=61 |issue= 1 |pages= 113-24 |year= 1990 |pmid= 2180582 |doi= }}
* {{cite journal | vauthors = Nagulapalli S, Pongubala JM, Atchison ML | title = Multiple proteins physically interact with PU.1. Transcriptional synergy with NF-IL6 beta (C/EBP delta, CRP3). | journal = J. Immunol. | volume = 155 | issue = 9 | pages = 4330–8 | year = 1995 | pmid = 7594592 | doi =  }}
*{{cite journal | author=Nguyen VC, Ray D, Gross MS, ''et al.'' |title=Localization of the human oncogene SPI1 on chromosome 11, region p11.22. |journal=Hum. Genet. |volume=84 |issue= 6 |pages= 542-6 |year= 1990 |pmid= 2338340 |doi=  }}
* {{cite journal | vauthors = Pongubala JM, Atchison ML | title = Activating transcription factor 1 and cyclic AMP response element modulator can modulate the activity of the immunoglobulin kappa 3' enhancer. | journal = J. Biol. Chem. | volume = 270 | issue = 17 | pages = 10304–13 | year = 1995 | pmid = 7730336 | doi = 10.1074/jbc.270.17.10304 }}
*{{cite journal | author=Chen H, Ray-Gallet D, Zhang P, ''et al.'' |title=PU.1 (Spi-1) autoregulates its expression in myeloid cells. |journal=Oncogene |volume=11 |issue= 8 |pages= 1549-60 |year= 1995 |pmid= 7478579 |doi=  }}
* {{cite journal | vauthors = Hromas R, Orazi A, Neiman RS, Maki R, Van Beveran C, Moore J, Klemsz M | title = Hematopoietic lineage- and stage-restricted expression of the ETS oncogene family member PU.1. | journal = Blood | volume = 82 | issue = 10 | pages = 2998–3004 | year = 1993 | pmid = 8219191 | doi =  }}
*{{cite journal | author=Nagulapalli S, Pongubala JM, Atchison ML |title=Multiple proteins physically interact with PU.1. Transcriptional synergy with NF-IL6 beta (C/EBP delta, CRP3). |journal=J. Immunol. |volume=155 |issue= 9 |pages= 4330-8 |year= 1995 |pmid= 7594592 |doi= }}
* {{cite journal | vauthors = Hagemeier C, Bannister AJ, Cook A, Kouzarides T | title = The activation domain of transcription factor PU.1 binds the retinoblastoma (RB) protein and the transcription factor TFIID in vitro: RB shows sequence similarity to TFIID and TFIIB. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 90 | issue = 4 | pages = 1580–4 | year = 1993 | pmid = 8434021 | pmc = 45918 | doi = 10.1073/pnas.90.4.1580 }}
*{{cite journal | author=Pongubala JM, Atchison ML |title=Activating transcription factor 1 and cyclic AMP response element modulator can modulate the activity of the immunoglobulin kappa 3' enhancer. |journal=J. Biol. Chem. |volume=270 |issue= 17 |pages= 10304-13 |year= 1995 |pmid= 7730336 |doi=  }}
* {{cite journal | vauthors = Hallier M, Tavitian A, Moreau-Gachelin F | title = The transcription factor Spi-1/PU.1 binds RNA and interferes with the RNA-binding protein p54nrb. | journal = J. Biol. Chem. | volume = 271 | issue = 19 | pages = 11177–81 | year = 1996 | pmid = 8626664 | doi = 10.1074/jbc.271.19.11177 }}
*{{cite journal | author=Hromas R, Orazi A, Neiman RS, ''et al.'' |title=Hematopoietic lineage- and stage-restricted expression of the ETS oncogene family member PU.1. |journal=Blood |volume=82 |issue= 10 |pages= 2998-3004 |year= 1993 |pmid= 8219191 |doi= }}
* {{cite journal | vauthors = Bassuk AG, Anandappa RT, Leiden JM | title = Physical interactions between Ets and NF-kappaB/NFAT proteins play an important role in their cooperative activation of the human immunodeficiency virus enhancer in T cells. | journal = J. Virol. | volume = 71 | issue = 5 | pages = 3563–73 | year = 1997 | pmid = 9094628 | pmc = 191503 | doi =  }}
*{{cite journal | author=Hagemeier C, Bannister AJ, Cook A, Kouzarides T |title=The activation domain of transcription factor PU.1 binds the retinoblastoma (RB) protein and the transcription factor TFIID in vitro: RB shows sequence similarity to TFIID and TFIIB. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 4 |pages= 1580-4 |year= 1993 |pmid= 8434021 |doi= }}
* {{cite journal | vauthors = Li SL, Valente AJ, Zhao SJ, Clark RA | title = PU.1 is essential for p47(phox) promoter activity in myeloid cells. | journal = J. Biol. Chem. | volume = 272 | issue = 28 | pages = 17802–9 | year = 1997 | pmid = 9211934 | doi = 10.1074/jbc.272.28.17802 }}
*{{cite journal | author=Hallier M, Tavitian A, Moreau-Gachelin F |title=The transcription factor Spi-1/PU.1 binds RNA and interferes with the RNA-binding protein p54nrb. |journal=J. Biol. Chem. |volume=271 |issue= 19 |pages= 11177-81 |year= 1996 |pmid= 8626664 |doi=  }}
* {{cite journal | vauthors = Tsukada J, Misago M, Serino Y, Ogawa R, Murakami S, Nakanishi M, Tonai S, Kominato Y, Morimoto I, Auron PE, Eto S | title = Human T-cell leukemia virus type I Tax transactivates the promoter of human prointerleukin-1beta gene through association with two transcription factors, nuclear factor-interleukin-6 and Spi-1. | journal = Blood | volume = 90 | issue = 8 | pages = 3142–53 | year = 1997 | pmid = 9376596 | doi =  }}
*{{cite journal | author=Bassuk AG, Anandappa RT, Leiden JM |title=Physical interactions between Ets and NF-kappaB/NFAT proteins play an important role in their cooperative activation of the human immunodeficiency virus enhancer in T cells. |journal=J. Virol. |volume=71 |issue= 5 |pages= 3563-73 |year= 1997 |pmid= 9094628 |doi= }}
* {{cite journal | vauthors = Hallier M, Lerga A, Barnache S, Tavitian A, Moreau-Gachelin F | title = The transcription factor Spi-1/PU.1 interacts with the potential splicing factor TLS. | journal = J. Biol. Chem. | volume = 273 | issue = 9 | pages = 4838–42 | year = 1998 | pmid = 9478924 | doi = 10.1074/jbc.273.9.4838 }}
*{{cite journal | author=Li SL, Valente AJ, Zhao SJ, Clark RA |title=PU.1 is essential for p47(phox) promoter activity in myeloid cells. |journal=J. Biol. Chem. |volume=272 |issue= 28 |pages= 17802-9 |year= 1997 |pmid= 9211934 |doi=  }}
* {{cite journal | vauthors = Suzuki S, Kumatori A, Haagen IA, Fujii Y, Sadat MA, Jun HL, Tsuji Y, Roos D, Nakamura M | title = PU.1 as an essential activator for the expression of gp91(phox) gene in human peripheral neutrophils, monocytes, and B lymphocytes. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 95 | issue = 11 | pages = 6085–90 | year = 1998 | pmid = 9600921 | pmc = 27589 | doi = 10.1073/pnas.95.11.6085 }}
*{{cite journal | author=Tsukada J, Misago M, Serino Y, ''et al.'' |title=Human T-cell leukemia virus type I Tax transactivates the promoter of human prointerleukin-1beta gene through association with two transcription factors, nuclear factor-interleukin-6 and Spi-1. |journal=Blood |volume=90 |issue= 8 |pages= 3142-53 |year= 1997 |pmid= 9376596 |doi= }}
* {{cite journal | vauthors = Carrère S, Verger A, Flourens A, Stehelin D, Duterque-Coquillaud M | title = Erg proteins, transcription factors of the Ets family, form homo, heterodimers and ternary complexes via two distinct domains. | journal = Oncogene | volume = 16 | issue = 25 | pages = 3261–8 | year = 1998 | pmid = 9681824 | doi = 10.1038/sj.onc.1201868 }}
*{{cite journal | author=Hallier M, Lerga A, Barnache S, ''et al.'' |title=The transcription factor Spi-1/PU.1 interacts with the potential splicing factor TLS. |journal=J. Biol. Chem. |volume=273 |issue= 9 |pages= 4838-42 |year= 1998 |pmid= 9478924 |doi= }}
* {{cite journal | vauthors = Sato M, Morii E, Takebayashi-Suzuki K, Yasui N, Ochi T, Kitamura Y, Nomura S | title = Microphthalmia-associated transcription factor interacts with PU.1 and c-Fos: determination of their subcellular localization. | journal = Biochem. Biophys. Res. Commun. | volume = 254 | issue = 2 | pages = 384–7 | year = 1999 | pmid = 9918847 | doi = 10.1006/bbrc.1998.9918 }}
*{{cite journal | author=Suzuki S, Kumatori A, Haagen IA, ''et al.'' |title=PU.1 as an essential activator for the expression of gp91(phox) gene in human peripheral neutrophils, monocytes, and B lymphocytes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 11 |pages= 6085-90 |year= 1998 |pmid= 9600921 |doi= }}
* {{cite journal | vauthors = Brass AL, Zhu AQ, Singh H | title = Assembly requirements of PU.1-Pip (IRF-4) activator complexes: inhibiting function in vivo using fused dimers. | journal = EMBO J. | volume = 18 | issue = 4 | pages = 977–91 | year = 1999 | pmid = 10022840 | pmc = 1171190 | doi = 10.1093/emboj/18.4.977 }}
*{{cite journal | author=Carrère S, Verger A, Flourens A, ''et al.'' |title=Erg proteins, transcription factors of the Ets family, form homo, heterodimers and ternary complexes via two distinct domains. |journal=Oncogene |volume=16 |issue= 25 |pages= 3261-8 |year= 1998 |pmid= 9681824 |doi= 10.1038/sj.onc.1201868 }}
* {{cite journal | vauthors = Yamamoto H, Kihara-Negishi F, Yamada T, Hashimoto Y, Oikawa T | title = Physical and functional interactions between the transcription factor PU.1 and the coactivator CBP. | journal = Oncogene | volume = 18 | issue = 7 | pages = 1495–501 | year = 1999 | pmid = 10050886 | doi = 10.1038/sj.onc.1202427 }}
*{{cite journal | author=Sato M, Morii E, Takebayashi-Suzuki K, ''et al.'' |title=Microphthalmia-associated transcription factor interacts with PU.1 and c-Fos: determination of their subcellular localization. |journal=Biochem. Biophys. Res. Commun. |volume=254 |issue= 2 |pages= 384-7 |year= 1999 |pmid= 9918847 |doi= 10.1006/bbrc.1998.9918 }}
* {{cite journal | vauthors = Rao S, Matsumura A, Yoon J, Simon MC | title = SPI-B activates transcription via a unique proline, serine, and threonine domain and exhibits DNA binding affinity differences from PU.1. | journal = J. Biol. Chem. | volume = 274 | issue = 16 | pages = 11115–24 | year = 1999 | pmid = 10196196 | doi = 10.1074/jbc.274.16.11115 }}
*{{cite journal | author=Brass AL, Zhu AQ, Singh H |title=Assembly requirements of PU.1-Pip (IRF-4) activator complexes: inhibiting function in vivo using fused dimers. |journal=EMBO J. |volume=18 |issue= 4 |pages= 977-91 |year= 1999 |pmid= 10022840 |doi= 10.1093/emboj/18.4.977 }}
* {{cite journal | vauthors = Mao S, Frank RC, Zhang J, Miyazaki Y, Nimer SD | title = Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias. | journal = Mol. Cell. Biol. | volume = 19 | issue = 5 | pages = 3635–44 | year = 1999 | pmid = 10207087 | pmc = 84165 | doi =  10.1128/mcb.19.5.3635}}
*{{cite journal | author=Yamamoto H, Kihara-Negishi F, Yamada T, ''et al.'' |title=Physical and functional interactions between the transcription factor PU.1 and the coactivator CBP. |journal=Oncogene |volume=18 |issue= 7 |pages= 1495-501 |year= 1999 |pmid= 10050886 |doi= 10.1038/sj.onc.1202427 }}
*{{cite journal | author=Rao S, Matsumura A, Yoon J, Simon MC |title=SPI-B activates transcription via a unique proline, serine, and threonine domain and exhibits DNA binding affinity differences from PU.1. |journal=J. Biol. Chem. |volume=274 |issue= 16 |pages= 11115-24 |year= 1999 |pmid= 10196196 |doi=  }}
*{{cite journal  | author=Mao S, Frank RC, Zhang J, ''et al.'' |title=Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias. |journal=Mol. Cell. Biol. |volume=19 |issue= 5 |pages= 3635-44 |year= 1999 |pmid= 10207087 |doi=  }}
}}
{{refend}}
{{refend}}
== External links ==
* {{FactorBook|PU.1}}
{{PDB Gallery|geneid=6688}}
{{Transcription factors}}


[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{Transcription factors}}
 
{{protein-stub}}
 
{{WikiDoc Sources}}
{{gene-11-stub}}

Revision as of 06:54, 11 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Transcription factor PU.1 is a protein that in humans is encoded by the SPI1 gene.[1]

Function

This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development[citation needed]. The nuclear protein binds to a purine-rich sequence known as the PU-box found near the promoters of target genes, and regulates their expression in coordination with other transcription factors and cofactors. The protein can also regulate alternative splicing of target genes. Multiple transcript variants encoding different isoforms have been found for this gene.[2]

Interactions

SPI1 has been shown to interact with:

See also

References

  1. ↑ Ray D, Culine S, Tavitain A, Moreau-Gachelin F (July 1990). "The human homologue of the putative proto-oncogene Spi-1: characterization and expression in tumors". Oncogene. 5 (5): 663–8. PMID 1693183.
  2. ↑ "Entrez Gene: SPI1 spleen focus forming virus (SFFV) proviral integration oncogene spi1".
  3. ↑ Hallier M, Lerga A, Barnache S, Tavitian A, Moreau-Gachelin F (February 1998). "The transcription factor Spi-1/PU.1 interacts with the potential splicing factor TLS". J. Biol. Chem. 273 (9): 4838–42. doi:10.1074/jbc.273.9.4838. PMID 9478924.
  4. ↑ Zhang P, Behre G, Pan J, Iwama A, Wara-Aswapati N, Radomska HS, Auron PE, Tenen DG, Sun Z (July 1999). "Negative cross-talk between hematopoietic regulators: GATA proteins repress PU.1". Proc. Natl. Acad. Sci. U.S.A. 96 (15): 8705–10. doi:10.1073/pnas.96.15.8705. PMC 17580. PMID 10411939.
  5. ↑ Brass AL, Zhu AQ, Singh H (February 1999). "Assembly requirements of PU.1-Pip (IRF-4) activator complexes: inhibiting function in vivo using fused dimers". EMBO J. 18 (4): 977–91. doi:10.1093/emboj/18.4.977. PMC 1171190. PMID 10022840.
  6. ↑ Escalante CR, Shen L, Escalante MC, Brass AL, Edwards TA, Singh H, Aggarwal AK (July 2002). "Crystallization and characterization of PU.1/IRF-4/DNA ternary complex". J. Struct. Biol. 139 (1): 55–9. doi:10.1016/s1047-8477(02)00514-2. PMID 12372320.
  7. ↑ Hallier M, Tavitian A, Moreau-Gachelin F (May 1996). "The transcription factor Spi-1/PU.1 binds RNA and interferes with the RNA-binding protein p54nrb". J. Biol. Chem. 271 (19): 11177–81. doi:10.1074/jbc.271.19.11177. PMID 8626664.

Further reading

External links


Retrieved from "https://www.wikidoc.org/index.php?title=SPI1&oldid=1414886"