SLC1A1: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''SLC1A1''', also known as '''excitatory amino-acid transporter 3''' ('''EAAT3'''), is a [[protein]] that in humans is encoded by the ''SLC1A1'' [[gene]].<ref name="pmid8020993">{{cite journal | vauthors = Smith CP, Weremowicz S, Kanai Y, Stelzner M, Morton CC, Hediger MA | title = Assignment of the gene coding for the human high-affinity glutamate transporter EAAC1 to 9p24: potential role in dicarboxylic aminoaciduria and neurodegenerative disorders | journal = Genomics | volume = 20 | issue = 2 | pages = 335–6  | date = August 1994 | pmid = 8020993 | pmc = | doi = 10.1006/geno.1994.1183 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6505 }}</ref>
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| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
| HGNCid = 10939
| Symbol = SLC1A1
| AltSymbols =; EAAC1; EAAT3
| OMIM = 133550
| ECnumber = 
| Homologene = 20881
| MGIid = 105083
| GeneAtlas_image1 = PBB_GE_SLC1A1_213664_at_tn.png
| GeneAtlas_image2 = PBB_GE_SLC1A1_206396_at_tn.png
| Function = {{GNF_GO|id=GO:0015293 |text = symporter activity}} {{GNF_GO|id=GO:0015501 |text = glutamate:sodium symporter activity}} {{GNF_GO|id=GO:0017153 |text = sodium:dicarboxylate symporter activity}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0006835 |text = dicarboxylic acid transport}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}} {{GNF_GO|id=GO:0015813 |text = glutamate transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6505
    | Hs_Ensembl = ENSG00000106688
    | Hs_RefseqProtein = NP_004161
    | Hs_RefseqmRNA = NM_004170
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 9
    | Hs_GenLoc_start = 4480444
    | Hs_GenLoc_end = 4577469
    | Hs_Uniprot = P43005
    | Mm_EntrezGene = 20510
    | Mm_Ensembl = ENSMUSG00000024935
    | Mm_RefseqmRNA = XM_001002136
    | Mm_RefseqProtein = XP_001002136
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 19
    | Mm_GenLoc_start = 28901132
    | Mm_GenLoc_end = 28979956
    | Mm_Uniprot = Q6P1F7
  }}
}}
'''Solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1''', also known as '''SLC1A1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6505| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Excitatory amino-acid transporter 3 is a member of the high-affinity [[glutamate transporter]]s which plays an essential role in transporting [[glutamate]] across [[plasma membrane]]s in [[neuron]]s. In the brain, excitatory amino acid transporters are crucial in terminating the postsynaptic action of the [[neurotransmitter]] glutamate, and in maintaining extracellular glutamate concentrations below neurotoxic levels. EAAT3 also transports [[aspartate]], and mutations in this gene are thought to cause [[dicarboxylic aminoaciduria]], also known as glutamate-aspartate transport defect.<ref name="entrez"/>  EAAT3 is also the major route of neuronal cysteine uptake.  Cysteine  is a component of the major antioxidant glutathione, and mice lacking EAAT3 exhibit reduced levels of glutathione in neurons, increased oxidative stress, and age-dependent loss of neurons, especially neurons of the substantia nigra.
{{PBB_Summary
| section_title =
| summary_text =
}}


==See also==
== Interactions ==
 
SLC1A1 has been shown to [[Protein-protein interaction|interact]] with [[ARL6IP5]].<ref name="pmid11242046">{{cite journal | vauthors = Lin CI, Orlov I, Ruggiero AM, Dykes-Hoberg M, Lee A, Jackson M, Rothstein JD | title = Modulation of the neuronal glutamate transporter EAAC1 by the interacting protein GTRAP3-18 | journal = Nature | volume = 410 | issue = 6824 | pages = 84–8 | year = 2001 | pmid = 11242046 | doi = 10.1038/35065084 }}</ref>
 
== See also ==
* [[Excitatory amino acid transporter]]
* [[Glutamate transporter]]
* [[Glutamate transporter]]
* [[Solute carrier family]]
* [[Solute carrier family]]


==References==
== References ==
{{reflist|2}}
{{Reflist}}
{{Clear}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{Refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Nieoullon A, Canolle B, Masmejean F, Guillet B, Pisano P, Lortet S | title = The neuronal excitatory amino acid transporter EAAC1/EAAT3: does it represent a major actor at the brain excitatory synapse? | journal = J. Neurochem. | volume = 98 | issue = 4 | pages = 1007–18 | year = 2006 | pmid = 16800850 | doi = 10.1111/j.1471-4159.2006.03978.x }}
| citations =
* {{cite journal | vauthors = Arriza JL, Fairman WA, Wadiche JI, Murdoch GH, Kavanaugh MP, Amara SG | title = Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex | journal = J. Neurosci. | volume = 14 | issue = 9 | pages = 5559–69 | year = 1994 | pmid = 7521911 | doi =  }}
*{{cite journal | author=Nieoullon A, Canolle B, Masmejean F, ''et al.'' |title=The neuronal excitatory amino acid transporter EAAC1/EAAT3: does it represent a major actor at the brain excitatory synapse? |journal=J. Neurochem. |volume=98 |issue= 4 |pages= 1007-18 |year= 2006 |pmid= 16800850 |doi= 10.1111/j.1471-4159.2006.03978.x }}
* {{cite journal | vauthors = Shashidharan P, Huntley GW, Meyer T, Morrison JH, Plaitakis A | title = Neuron-specific human glutamate transporter: molecular cloning, characterization and expression in human brain | journal = Brain Res. | volume = 662 | issue = 1-2 | pages = 245–50 | year = 1994 | pmid = 7859077 | doi = 10.1016/0006-8993(94)90819-2 }}
*{{cite journal | author=Arriza JL, Fairman WA, Wadiche JI, ''et al.'' |title=Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex. |journal=J. Neurosci. |volume=14 |issue= 9 |pages= 5559-69 |year= 1994 |pmid= 7521911 |doi=  }}
* {{cite journal | vauthors = Kanai Y, Stelzner M, Nussberger S, Khawaja S, Hebert SC, Smith CP, Hediger MA | title = The neuronal and epithelial human high affinity glutamate transporter. Insights into structure and mechanism of transport | journal = J. Biol. Chem. | volume = 269 | issue = 32 | pages = 20599–606 | year = 1994 | pmid = 7914198 | doi =  }}
*{{cite journal | author=Shashidharan P, Huntley GW, Meyer T, ''et al.'' |title=Neuron-specific human glutamate transporter: molecular cloning, characterization and expression in human brain. |journal=Brain Res. |volume=662 |issue= 1-2 |pages= 245-50 |year= 1995 |pmid= 7859077 |doi= }}
* {{cite journal | vauthors = Zerangue N, Kavanaugh MP | title = Interaction of L-cysteine with a human excitatory amino acid transporter | journal = J. Physiol. | volume = 493 | issue = Pt 2 | pages = 419–23 | year = 1996 | pmid = 8782106 | pmc = 1158927 | doi =  10.1113/jphysiol.1996.sp021393}}
*{{cite journal | author=Kanai Y, Stelzner M, Nussberger S, ''et al.'' |title=The neuronal and epithelial human high affinity glutamate transporter. Insights into structure and mechanism of transport. |journal=J. Biol. Chem. |volume=269 |issue= 32 |pages= 20599-606 |year= 1994 |pmid= 7914198 |doi=  }}
* {{cite journal | vauthors = Bar-Peled O, Ben-Hur H, Biegon A, Groner Y, Dewhurst S, Furuta A, Rothstein JD | title = Distribution of glutamate transporter subtypes during human brain development | journal = J. Neurochem. | volume = 69 | issue = 6 | pages = 2571–80 | year = 1997 | pmid = 9375691 | doi = 10.1046/j.1471-4159.1997.69062571.x }}
*{{cite journal | author=Smith CP, Weremowicz S, Kanai Y, ''et al.'' |title=Assignment of the gene coding for the human high-affinity glutamate transporter EAAC1 to 9p24: potential role in dicarboxylic aminoaciduria and neurodegenerative disorders. |journal=Genomics |volume=20 |issue= 2 |pages= 335-6 |year= 1994 |pmid= 8020993 |doi= 10.1006/geno.1994.1183 }}
* {{cite journal | vauthors = He Y, Janssen WG, Rothstein JD, Morrison JH | title = Differential synaptic localization of the glutamate transporter EAAC1 and glutamate receptor subunit GluR2 in the rat hippocampus | journal = J. Comp. Neurol. | volume = 418 | issue = 3 | pages = 255–69 | year = 2000 | pmid = 10701825 | doi = 10.1002/(SICI)1096-9861(20000313)418:3<255::AID-CNE2>3.0.CO;2-6 }}
*{{cite journal  | author=Zerangue N, Kavanaugh MP |title=Interaction of L-cysteine with a human excitatory amino acid transporter. |journal=J. Physiol. (Lond.) |volume=493 ( Pt 2) |issue= |pages= 419-23 |year= 1997 |pmid= 8782106 |doi=  }}
* {{cite journal | vauthors = Lin CI, Orlov I, Ruggiero AM, Dykes-Hoberg M, Lee A, Jackson M, Rothstein JD | title = Modulation of the neuronal glutamate transporter EAAC1 by the interacting protein GTRAP3-18 | journal = Nature | volume = 410 | issue = 6824 | pages = 84–8 | year = 2001 | pmid = 11242046 | doi = 10.1038/35065084 }}
*{{cite journal | author=Bar-Peled O, Ben-Hur H, Biegon A, ''et al.'' |title=Distribution of glutamate transporter subtypes during human brain development. |journal=J. Neurochem. |volume=69 |issue= 6 |pages= 2571-80 |year= 1997 |pmid= 9375691 |doi= }}
* {{cite journal | vauthors = Veenstra-VanderWeele J, Kim SJ, Gonen D, Hanna GL, Leventhal BL, Cook EH | title = Genomic organization of the SLC1A1/EAAC1 gene and mutation screening in early-onset obsessive-compulsive disorder | journal = Mol. Psychiatry | volume = 6 | issue = 2 | pages = 160–7 | year = 2001 | pmid = 11317217 | doi = 10.1038/sj.mp.4000806 }}
*{{cite journal | author=He Y, Janssen WG, Rothstein JD, Morrison JH |title=Differential synaptic localization of the glutamate transporter EAAC1 and glutamate receptor subunit GluR2 in the rat hippocampus. |journal=J. Comp. Neurol. |volume=418 |issue= 3 |pages= 255-69 |year= 2000 |pmid= 10701825 |doi= }}
* {{cite journal | vauthors = Borre L, Kavanaugh MP, Kanner BI | title = Dynamic equilibrium between coupled and uncoupled modes of a neuronal glutamate transporter | journal = J. Biol. Chem. | volume = 277 | issue = 16 | pages = 13501–7 | year = 2002 | pmid = 11823462 | doi = 10.1074/jbc.M110861200 }}
*{{cite journal | author=Lin CI, Orlov I, Ruggiero AM, ''et al.'' |title=Modulation of the neuronal glutamate transporter EAAC1 by the interacting protein GTRAP3-18. |journal=Nature |volume=410 |issue= 6824 |pages= 84-8 |year= 2001 |pmid= 11242046 |doi= 10.1038/35065084 }}
* {{cite journal | vauthors = González MI, Bannerman PG, Robinson MB | title = Phorbol myristate acetate-dependent interaction of protein kinase Calpha and the neuronal glutamate transporter EAAC1 | journal = J. Neurosci. | volume = 23 | issue = 13 | pages = 5589–93 | year = 2003 | pmid = 12843260 | doi =  }}
*{{cite journal | author=Veenstra-VanderWeele J, Kim SJ, Gonen D, ''et al.'' |title=Genomic organization of the SLC1A1/EAAC1 gene and mutation screening in early-onset obsessive-compulsive disorder. |journal=Mol. Psychiatry |volume=6 |issue= 2 |pages= 160-7 |year= 2001 |pmid= 11317217 |doi= 10.1038/sj.mp.4000806 }}
* {{cite journal | vauthors = Noorlander CW, de Graan PN, Nikkels PG, Schrama LH, Visser GH | title = Distribution of glutamate transporters in the human placenta | journal = Placenta | volume = 25 | issue = 6 | pages = 489–95 | year = 2004 | pmid = 15135231 | doi = 10.1016/j.placenta.2003.10.018 }}
*{{cite journal | author=Borre L, Kavanaugh MP, Kanner BI |title=Dynamic equilibrium between coupled and uncoupled modes of a neuronal glutamate transporter. |journal=J. Biol. Chem. |volume=277 |issue= 16 |pages= 13501-7 |year= 2002 |pmid= 11823462 |doi= 10.1074/jbc.M110861200 }}
* {{cite journal | vauthors = Koch HP, Larsson HP | title = Small-scale molecular motions accomplish glutamate uptake in human glutamate transporters | journal = J. Neurosci. | volume = 25 | issue = 7 | pages = 1730–6 | year = 2005 | pmid = 15716409 | doi = 10.1523/JNEUROSCI.4138-04.2005 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Vallejo-Illarramendi A, Domercq M, Pérez-Cerdá F, Ravid R, Matute C | title = Increased expression and function of glutamate transporters in multiple sclerosis | journal = Neurobiol. Dis. | volume = 21 | issue = 1 | pages = 154–64 | year = 2006 | pmid = 16061389 | doi = 10.1016/j.nbd.2005.06.017 }}
*{{cite journal  | author=González MI, Bannerman PG, Robinson MB |title=Phorbol myristate acetate-dependent interaction of protein kinase Calpha and the neuronal glutamate transporter EAAC1. |journal=J. Neurosci. |volume=23 |issue= 13 |pages= 5589-93 |year= 2003 |pmid= 12843260 |doi=  }}
* {{cite journal|authorlink30=Huda Zoghbi | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal | author=Noorlander CW, de Graan PN, Nikkels PG, ''et al.'' |title=Distribution of glutamate transporters in the human placenta. |journal=Placenta |volume=25 |issue= 6 |pages= 489-95 |year= 2004 |pmid= 15135231 |doi= 10.1016/j.placenta.2003.10.018 }}
* {{cite journal | vauthors = Rainesalo S, Keränen T, Saransaari P, Honkaniemi J | title = GABA and glutamate transporters are expressed in human platelets | journal = Brain Res. Mol. Brain Res. | volume = 141 | issue = 2 | pages = 161–5 | year = 2005 | pmid = 16198020 | doi = 10.1016/j.molbrainres.2005.08.013 }}
*{{cite journal | author=Humphray SJ, Oliver K, Hunt AR, ''et al.'' |title=DNA sequence and analysis of human chromosome 9. |journal=Nature |volume=429 |issue= 6990 |pages= 369-74 |year= 2004 |pmid= 15164053 |doi= 10.1038/nature02465 }}
{{Refend}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Koch HP, Larsson HP |title=Small-scale molecular motions accomplish glutamate uptake in human glutamate transporters. |journal=J. Neurosci. |volume=25 |issue= 7 |pages= 1730-6 |year= 2005 |pmid= 15716409 |doi= 10.1523/JNEUROSCI.4138-04.2005 }}
*{{cite journal | author=Vallejo-Illarramendi A, Domercq M, Pérez-Cerdá F, ''et al.'' |title=Increased expression and function of glutamate transporters in multiple sclerosis. |journal=Neurobiol. Dis. |volume=21 |issue= 1 |pages= 154-64 |year= 2006 |pmid= 16061389 |doi= 10.1016/j.nbd.2005.06.017 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Rainesalo S, Keränen T, Saransaari P, Honkaniemi J |title=GABA and glutamate transporters are expressed in human platelets. |journal=Brain Res. Mol. Brain Res. |volume=141 |issue= 2 |pages= 161-5 |year= 2006 |pmid= 16198020 |doi= 10.1016/j.molbrainres.2005.08.013 }}
}}
{{refend}}


{{membrane-protein-stub}}
{{NLM content}}
{{NLM content}}
{{Membrane transport proteins}}
{{Amphetamine}}
{{Solute carrier family|bg|bg0}}
{{Glutamate metabolism and transport modulators}}
 
[[Category:Amphetamine]]
[[Category:Solute carrier family]]
[[Category:Solute carrier family]]
{{WikiDoc Sources}}
[[Category:Neurotransmitter transporters]]
[[Category:Glutamate (neurotransmitter)]]
 
 
{{Membrane-protein-stub}}

Latest revision as of 16:16, 8 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

SLC1A1, also known as excitatory amino-acid transporter 3 (EAAT3), is a protein that in humans is encoded by the SLC1A1 gene.[1][2]

Function

Excitatory amino-acid transporter 3 is a member of the high-affinity glutamate transporters which plays an essential role in transporting glutamate across plasma membranes in neurons. In the brain, excitatory amino acid transporters are crucial in terminating the postsynaptic action of the neurotransmitter glutamate, and in maintaining extracellular glutamate concentrations below neurotoxic levels. EAAT3 also transports aspartate, and mutations in this gene are thought to cause dicarboxylic aminoaciduria, also known as glutamate-aspartate transport defect.[2] EAAT3 is also the major route of neuronal cysteine uptake. Cysteine is a component of the major antioxidant glutathione, and mice lacking EAAT3 exhibit reduced levels of glutathione in neurons, increased oxidative stress, and age-dependent loss of neurons, especially neurons of the substantia nigra.

Interactions

SLC1A1 has been shown to interact with ARL6IP5.[3]

See also

References

  1. ↑ Smith CP, Weremowicz S, Kanai Y, Stelzner M, Morton CC, Hediger MA (August 1994). "Assignment of the gene coding for the human high-affinity glutamate transporter EAAC1 to 9p24: potential role in dicarboxylic aminoaciduria and neurodegenerative disorders". Genomics. 20 (2): 335–6. doi:10.1006/geno.1994.1183. PMID 8020993.
  2. ↑ 2.0 2.1 "Entrez Gene: SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1".
  3. ↑ Lin CI, Orlov I, Ruggiero AM, Dykes-Hoberg M, Lee A, Jackson M, Rothstein JD (2001). "Modulation of the neuronal glutamate transporter EAAC1 by the interacting protein GTRAP3-18". Nature. 410 (6824): 84–8. doi:10.1038/35065084. PMID 11242046.

Further reading

  • Nieoullon A, Canolle B, Masmejean F, Guillet B, Pisano P, Lortet S (2006). "The neuronal excitatory amino acid transporter EAAC1/EAAT3: does it represent a major actor at the brain excitatory synapse?". J. Neurochem. 98 (4): 1007–18. doi:10.1111/j.1471-4159.2006.03978.x. PMID 16800850.
  • Arriza JL, Fairman WA, Wadiche JI, Murdoch GH, Kavanaugh MP, Amara SG (1994). "Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex". J. Neurosci. 14 (9): 5559–69. PMID 7521911.
  • Shashidharan P, Huntley GW, Meyer T, Morrison JH, Plaitakis A (1994). "Neuron-specific human glutamate transporter: molecular cloning, characterization and expression in human brain". Brain Res. 662 (1–2): 245–50. doi:10.1016/0006-8993(94)90819-2. PMID 7859077.
  • Kanai Y, Stelzner M, Nussberger S, Khawaja S, Hebert SC, Smith CP, Hediger MA (1994). "The neuronal and epithelial human high affinity glutamate transporter. Insights into structure and mechanism of transport". J. Biol. Chem. 269 (32): 20599–606. PMID 7914198.
  • Zerangue N, Kavanaugh MP (1996). "Interaction of L-cysteine with a human excitatory amino acid transporter". J. Physiol. 493 (Pt 2): 419–23. doi:10.1113/jphysiol.1996.sp021393. PMC 1158927. PMID 8782106.
  • Bar-Peled O, Ben-Hur H, Biegon A, Groner Y, Dewhurst S, Furuta A, Rothstein JD (1997). "Distribution of glutamate transporter subtypes during human brain development". J. Neurochem. 69 (6): 2571–80. doi:10.1046/j.1471-4159.1997.69062571.x. PMID 9375691.
  • He Y, Janssen WG, Rothstein JD, Morrison JH (2000). "Differential synaptic localization of the glutamate transporter EAAC1 and glutamate receptor subunit GluR2 in the rat hippocampus". J. Comp. Neurol. 418 (3): 255–69. doi:10.1002/(SICI)1096-9861(20000313)418:3<255::AID-CNE2>3.0.CO;2-6. PMID 10701825.
  • Lin CI, Orlov I, Ruggiero AM, Dykes-Hoberg M, Lee A, Jackson M, Rothstein JD (2001). "Modulation of the neuronal glutamate transporter EAAC1 by the interacting protein GTRAP3-18". Nature. 410 (6824): 84–8. doi:10.1038/35065084. PMID 11242046.
  • Veenstra-VanderWeele J, Kim SJ, Gonen D, Hanna GL, Leventhal BL, Cook EH (2001). "Genomic organization of the SLC1A1/EAAC1 gene and mutation screening in early-onset obsessive-compulsive disorder". Mol. Psychiatry. 6 (2): 160–7. doi:10.1038/sj.mp.4000806. PMID 11317217.
  • Borre L, Kavanaugh MP, Kanner BI (2002). "Dynamic equilibrium between coupled and uncoupled modes of a neuronal glutamate transporter". J. Biol. Chem. 277 (16): 13501–7. doi:10.1074/jbc.M110861200. PMID 11823462.
  • González MI, Bannerman PG, Robinson MB (2003). "Phorbol myristate acetate-dependent interaction of protein kinase Calpha and the neuronal glutamate transporter EAAC1". J. Neurosci. 23 (13): 5589–93. PMID 12843260.
  • Noorlander CW, de Graan PN, Nikkels PG, Schrama LH, Visser GH (2004). "Distribution of glutamate transporters in the human placenta". Placenta. 25 (6): 489–95. doi:10.1016/j.placenta.2003.10.018. PMID 15135231.
  • Koch HP, Larsson HP (2005). "Small-scale molecular motions accomplish glutamate uptake in human glutamate transporters". J. Neurosci. 25 (7): 1730–6. doi:10.1523/JNEUROSCI.4138-04.2005. PMID 15716409.
  • Vallejo-Illarramendi A, Domercq M, Pérez-Cerdá F, Ravid R, Matute C (2006). "Increased expression and function of glutamate transporters in multiple sclerosis". Neurobiol. Dis. 21 (1): 154–64. doi:10.1016/j.nbd.2005.06.017. PMID 16061389.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  • Rainesalo S, Keränen T, Saransaari P, Honkaniemi J (2005). "GABA and glutamate transporters are expressed in human platelets". Brain Res. Mol. Brain Res. 141 (2): 161–5. doi:10.1016/j.molbrainres.2005.08.013. PMID 16198020.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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