Vesicular monoamine transporter

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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Overview

The vesicular monoamine transporter is a transport protein located within the presynaptic cell.

Isoforms

It comprises the two isoforms:

Substrates

Substrates for the transporter is mainly noradrenaline, adrenaline and isoprenaline. However, other substrates include dopamine, 5-HT, guanethidine and MPP+.[1]

Clinicial significance

It can be inhibited by reserpine and tetrabenazine.[1]

VMAT is the main target of methamphetamine. By acting as a competitive antagonist, methamphetamine blocks the presynaptic cell's ability to use VMAT to package the above mentioned neurotransmitters into vesicles. The result is increased neurotransimtter release that is not dependent on the phasic activity of the presynaptic cell.

References

  1. 1.0 1.1 Rang, H. P. (2003). Pharmacology. Edinburgh: Churchill Livingstone. ISBN 0-443-07145-4. Page 167

Further reading

  • Kilbourn MR (1997). "In vivo radiotracers for vesicular neurotransmitter transporters". Nucl. Med. Biol. 24 (7): 615–9. PMID 9352531.

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