Raltitrexed: Difference between revisions
m (Protected "Raltitrexed": Protecting pages from unwanted edits ([edit=sysop] (indefinite) [move=sysop] (indefinite))) |
m (Robot: Automated text replacement (-{{SIB}} +, -{{EH}} +, -{{EJ}} +, -{{Editor Help}} +, -{{Editor Join}} +)) |
||
Line 25: | Line 25: | ||
}} | }} | ||
{{SI}} | {{SI}} | ||
==Overview== | ==Overview== | ||
Line 40: | Line 40: | ||
{{Chemotherapeutic agents}} | {{Chemotherapeutic agents}} | ||
[[Category:Thiophenes]] | [[Category:Thiophenes]] | ||
[[Category:Chemotherapeutic agents]] | [[Category:Chemotherapeutic agents]] | ||
{{WH}} | {{WH}} | ||
{{WikiDoc Sources}} | {{WikiDoc Sources}} |
Revision as of 15:32, 20 August 2012
File:Raltitrexed.svg | |
Clinical data | |
---|---|
ATC code | |
Identifiers | |
| |
CAS Number | |
PubChem CID | |
DrugBank | |
E number | {{#property:P628}} |
ECHA InfoCard | {{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value). |
Chemical and physical data | |
Formula | C21H22N4O6S |
Molar mass | 458.489 g/mol |
WikiDoc Resources for Raltitrexed |
Articles |
---|
Most recent articles on Raltitrexed Most cited articles on Raltitrexed |
Media |
Powerpoint slides on Raltitrexed |
Evidence Based Medicine |
Clinical Trials |
Ongoing Trials on Raltitrexed at Clinical Trials.gov Clinical Trials on Raltitrexed at Google
|
Guidelines / Policies / Govt |
US National Guidelines Clearinghouse on Raltitrexed
|
Books |
News |
Commentary |
Definitions |
Patient Resources / Community |
Patient resources on Raltitrexed Discussion groups on Raltitrexed Patient Handouts on Raltitrexed Directions to Hospitals Treating Raltitrexed Risk calculators and risk factors for Raltitrexed
|
Healthcare Provider Resources |
Causes & Risk Factors for Raltitrexed |
Continuing Medical Education (CME) |
International |
|
Business |
Experimental / Informatics |
Overview
Raltitrexed (brand name Tomudex®) is a chemotherapy drug manufactured AstraZeneca Company, is an antimetabolite used in chemotherapy. It is an inhibitor of thymidylate synthase.
Uses
Used in treatment of colorectal cancer since 1998.
Mechanism of action
Raltitrexed is chemically similar to folic acid and is in the class of chemotherapy drugs called folate antimetabolites. It works by inhibiting enzyme used in pyrimidine synthesis —thymidylate synthase (TS). Raltitrexed is fully active after polyglutamylation. Inhibition of L1210 cell growth i culture IC50 = 9 nM, is one of the strongest antimetabolite in use. By inhibiting the formation of precursor pyrimidine nucleotides, raltitrexed prevents the formation of DNA and RNA, which are required for the growth and survival of both normal cells and cancer cells.
- Pages with script errors
- E number from Wikidata
- ECHA InfoCard ID from Wikidata
- Articles without EBI source
- Chemical pages without ChemSpiderID
- Articles without KEGG source
- Articles without InChI source
- Articles without UNII source
- Drugs with no legal status
- Articles containing unverified chemical infoboxes
- Thiophenes
- Chemotherapeutic agents