NEUROD1: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Neurogenic differentiation 1''' ('''NeuroD1'''), also called '''β2''',<ref>{{cite journal | vauthors = Poulin G, Turgeon B, Drouin J | title = NeuroD1/beta2 contributes to cell-specific transcription of the proopiomelanocortin gene | journal = Molecular and Cellular Biology | volume = 17 | issue = 11 | pages = 6673–82 | date = Nov 1997 | pmid = 9343431 | pmc = 232521 | url = http://mcb.asm.org/cgi/pmidlookup?view=long&pmid=9343431 | doi=10.1128/mcb.17.11.6673}}</ref> is a [[transcription factor]] of the [[NeuroD]]-type. It is encoded by the human gene '''NEUROD1'''.
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
It is a member of the NeuroD family of [[basic helix-loop-helix]] (bHLH) [[transcription factor]]s. The protein forms heterodimers with other bHLH proteins and activates transcription of genes that contain a specific DNA sequence known as the E-box. It regulates expression of the [[insulin gene]], and mutations in this gene result in [[type II diabetes mellitus]].<ref name="entrez">{{cite web | title = Entrez Gene: NEUROD1 neurogenic differentiation 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4760| accessdate = }}</ref>
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Neurogenic differentiation 1
| HGNCid = 7762
| Symbol = NEUROD1
| AltSymbols =; BETA2; BHF-1; NEUROD
| OMIM = 601724
| ECnumber = 
| Homologene = 1871
| MGIid = 1339708
| GeneAtlas_image1 = PBB_GE_NEUROD1_206282_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003702 |text = RNA polymerase II transcription factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016563 |text = transcription activator activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007399 |text = nervous system development}} {{GNF_GO|id=GO:0009952 |text = anterior/posterior pattern formation}} {{GNF_GO|id=GO:0030902 |text = hindbrain development}} {{GNF_GO|id=GO:0045165 |text = cell fate commitment}} {{GNF_GO|id=GO:0045944 |text = positive regulation of transcription from RNA polymerase II promoter}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4760
    | Hs_Ensembl = ENSG00000162992
    | Hs_RefseqProtein = NP_002491
    | Hs_RefseqmRNA = NM_002500
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 182249440
    | Hs_GenLoc_end = 182253499
    | Hs_Uniprot = Q13562
    | Mm_EntrezGene = 18012
    | Mm_Ensembl = ENSMUSG00000034701
    | Mm_RefseqmRNA = NM_010894
    | Mm_RefseqProtein = NP_035024
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 79253480
    | Mm_GenLoc_end = 79257479
    | Mm_Uniprot = P70449
  }}
}}
'''Neurogenic differentiation 1''' ('''NeuroD1'''), also called '''β2'''<ref>[http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=232521 NeuroD1/beta2 contributes to cell-specific transcription of the ...]</ref> is a [[transcription factor]] of the [[NeuroD]]-type. It is encoded by the human gene '''NEUROD1'''.


It is a member of the NeuroD family of [[basic-helix-loop-helix]] (bHLH) [[transcription factor]]s. The protein forms heterodimers with other bHLH proteins and activates transcription of genes that contain a specific DNA sequence known as the E-box. It regulates expression of the [[insulin gene]], and mutations in this gene result in [[type II diabetes mellitus]].<ref name="entrez">{{cite web | title = Entrez Gene: NEUROD1 neurogenic differentiation 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4760| accessdate = }}</ref>
== Interactions ==


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
NEUROD1 has been shown to [[Protein-protein interaction|interact]] with [[MAP3K10]],<ref name=pmid12881483>{{cite journal | vauthors = Marcora E, Gowan K, Lee JE | title = Stimulation of NeuroD activity by huntingtin and huntingtin-associated proteins HAP1 and MLK2 | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 100 | issue = 16 | pages = 9578–83 | date = Aug 2003 | pmid = 12881483 | pmc = 170960 | doi = 10.1073/pnas.1133382100 }}</ref> [[MAFA (gene)|MAFA]]<ref name=pmid15665000>{{cite journal | vauthors = Zhao L, Guo M, Matsuoka TA, Hagman DK, Parazzoli SD, Poitout V, Stein R | title = The islet beta cell-enriched MafA activator is a key regulator of insulin gene transcription | journal = The Journal of Biological Chemistry | volume = 280 | issue = 12 | pages = 11887–94 | date = Mar 2005 | pmid = 15665000 | doi = 10.1074/jbc.M409475200 }}</ref> and [[Cyclin D1]].<ref name=pmid11788592>{{cite journal | vauthors = Ratineau C, Petry MW, Mutoh H, Leiter AB | title = Cyclin D1 represses the basic helix-loop-helix transcription factor, BETA2/NeuroD | journal = The Journal of Biological Chemistry | volume = 277 | issue = 11 | pages = 8847–53 | date = Mar 2002 | pmid = 11788592 | doi = 10.1074/jbc.M110747200 }}</ref>
{{PBB_Summary
| section_title =  
| summary_text =  
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Fajans SS, Bell GI, Polonsky KS | title = Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young | journal = The New England Journal of Medicine | volume = 345 | issue = 13 | pages = 971–80 | date = Sep 2001 | pmid = 11575290 | doi = 10.1056/NEJMra002168 }}
| citations =
* {{cite journal | vauthors = Cho JH, Tsai MJ | title = The role of BETA2/NeuroD1 in the development of the nervous system | journal = Molecular Neurobiology | volume = 30 | issue = 1 | pages = 35–47 | date = Aug 2004 | pmid = 15247487 | doi = 10.1385/MN:30:1:035 }}
*{{cite journal | author=Fajans SS, Bell GI, Polonsky KS |title=Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young. |journal=N. Engl. J. Med. |volume=345 |issue= 13 |pages= 971-80 |year= 2001 |pmid= 11575290 |doi= }}
* {{cite journal | vauthors = Chae JH, Stein GH, Lee JE | title = NeuroD: the predicted and the surprising | journal = Molecules and Cells | volume = 18 | issue = 3 | pages = 271–88 | date = Dec 2004 | pmid = 15650322 }}
*{{cite journal | author=Cho JH, Tsai MJ |title=The role of BETA2/NeuroD1 in the development of the nervous system. |journal=Mol. Neurobiol. |volume=30 |issue= 1 |pages= 35-47 |year= 2004 |pmid= 15247487 |doi= }}
* {{cite journal | vauthors = Tamimi R, Steingrimsson E, Copeland NG, Dyer-Montgomery K, Lee JE, Hernandez R, Jenkins NA, Tapscott SJ | title = The NEUROD gene maps to human chromosome 2q32 and mouse chromosome 2 | journal = Genomics | volume = 34 | issue = 3 | pages = 418–21 | date = Jun 1996 | pmid = 8786144 | doi = 10.1006/geno.1996.0306 }}
*{{cite journal | author=Chae JH, Stein GH, Lee JE |title=NeuroD: the predicted and the surprising. |journal=Mol. Cells |volume=18 |issue= 3 |pages= 271-88 |year= 2005 |pmid= 15650322 |doi=  }}
* {{cite journal | vauthors = Yokoyama M, Nishi Y, Miyamoto Y, Nakamura M, Akiyama K, Matsubara K, Okubo K | title = Molecular cloning of a human neuroD from a neuroblastoma cell line specifically expressed in the fetal brain and adult cerebellum | journal = Brain Research. Molecular Brain Research | volume = 42 | issue = 1 | pages = 135–9 | date = Nov 1996 | pmid = 8915591 | doi = 10.1016/S0169-328X(96)00154-4 }}
*{{cite journal | author=Tamimi R, Steingrimsson E, Copeland NG, ''et al.'' |title=The NEUROD gene maps to human chromosome 2q32 and mouse chromosome 2. |journal=Genomics |volume=34 |issue= 3 |pages= 418-21 |year= 1996 |pmid= 8786144 |doi= 10.1006/geno.1996.0306 }}
* {{cite journal | vauthors = Yokoyama M, Nishi Y, Yoshii J, Okubo K, Matsubara K | title = Identification and cloning of neuroblastoma-specific and nerve tissue-specific genes through compiled expression profiles | journal = DNA Research | volume = 3 | issue = 5 | pages = 311–20 | date = Oct 1996 | pmid = 9039501 | doi = 10.1093/dnares/3.5.311 }}
*{{cite journal | author=Yokoyama M, Nishi Y, Miyamoto Y, ''et al.'' |title=Molecular cloning of a human neuroD from a neuroblastoma cell line specifically expressed in the fetal brain and adult cerebellum. |journal=Brain Res. Mol. Brain Res. |volume=42 |issue= 1 |pages= 135-9 |year= 1997 |pmid= 8915591 |doi= }}
* {{cite journal | vauthors = Acharya HR, Dooley CM, Thoreson WB, Ahmad I | title = cDNA cloning and expression analysis of NeuroD mRNA in human retina | journal = Biochemical and Biophysical Research Communications | volume = 233 | issue = 2 | pages = 459–63 | date = Apr 1997 | pmid = 9144558 | doi = 10.1006/bbrc.1997.6483 }}
*{{cite journal | author=Yokoyama M, Nishi Y, Yoshii J, ''et al.'' |title=Identification and cloning of neuroblastoma-specific and nerve tissue-specific genes through compiled expression profiles. |journal=DNA Res. |volume=3 |issue= 5 |pages= 311-20 |year= 1997 |pmid= 9039501 |doi= }}
* {{cite journal | vauthors = Poulin G, Turgeon B, Drouin J | title = NeuroD1/beta2 contributes to cell-specific transcription of the proopiomelanocortin gene | journal = Molecular and Cellular Biology | volume = 17 | issue = 11 | pages = 6673–82 | date = Nov 1997 | pmid = 9343431 | pmc = 232521 | doi=10.1128/mcb.17.11.6673}}
*{{cite journal | author=Acharya HR, Dooley CM, Thoreson WB, Ahmad I |title=cDNA cloning and expression analysis of NeuroD mRNA in human retina. |journal=Biochem. Biophys. Res. Commun. |volume=233 |issue= 2 |pages= 459-63 |year= 1997 |pmid= 9144558 |doi= 10.1006/bbrc.1997.6483 }}
* {{cite journal | vauthors = Furuta H, Horikawa Y, Iwasaki N, Hara M, Sussel L, Le Beau MM, Davis EM, Ogata M, Iwamoto Y, German MS, Bell GI | title = Beta-cell transcription factors and diabetes: mutations in the coding region of the BETA2/NeuroD1 (NEUROD1) and Nkx2.2 (NKX2B) genes are not associated with maturity-onset diabetes of the young in Japanese | journal = Diabetes | volume = 47 | issue = 8 | pages = 1356–8 | date = Aug 1998 | pmid = 9703340 | doi = 10.2337/diabetes.47.8.1356 }}
*{{cite journal | author=Poulin G, Turgeon B, Drouin J |title=NeuroD1/beta2 contributes to cell-specific transcription of the proopiomelanocortin gene. |journal=Mol. Cell. Biol. |volume=17 |issue= 11 |pages= 6673-82 |year= 1997 |pmid= 9343431 |doi= }}
* {{cite journal | vauthors = Yoon YS, Noma T, Yamashiro Y, Ito H, Nakazawa A | title = Molecular cloning and characterization of the gene encoding human NeuroD | journal = Neuroscience Letters | volume = 251 | issue = 1 | pages = 17–20 | date = Jul 1998 | pmid = 9714454 | doi = 10.1016/S0304-3940(98)00490-X }}
*{{cite journal | author=Furuta H, Horikawa Y, Iwasaki N, ''et al.'' |title=Beta-cell transcription factors and diabetes: mutations in the coding region of the BETA2/NeuroD1 (NEUROD1) and Nkx2.2 (NKX2B) genes are not associated with maturity-onset diabetes of the young in Japanese. |journal=Diabetes |volume=47 |issue= 8 |pages= 1356-8 |year= 1998 |pmid= 9703340 |doi= }}
* {{cite journal | vauthors = Miyachi T, Maruyama H, Kitamura T, Nakamura S, Kawakami H | title = Structure and regulation of the human NeuroD (BETA2/BHF1) gene | journal = Brain Research. Molecular Brain Research | volume = 69 | issue = 2 | pages = 223–31 | date = Jun 1999 | pmid = 10366743 | doi = 10.1016/S0169-328X(99)00112-6 }}
*{{cite journal | author=Yoon YS, Noma T, Yamashiro Y, ''et al.'' |title=Molecular cloning and characterization of the gene encoding human NeuroD. |journal=Neurosci. Lett. |volume=251 |issue= 1 |pages= 17-20 |year= 1998 |pmid= 9714454 |doi= }}
* {{cite journal | vauthors = Noma T, Yoon YS, Yamashiro Y, Fujisawa K, Nakazawa A | title = Regulation of NeuroD expression by activation of the protein kinase-C pathway in Y79 human retinoblastoma cells | journal = Neuroscience Letters | volume = 272 | issue = 1 | pages = 45–8 | date = Sep 1999 | pmid = 10507539 | doi = 10.1016/S0304-3940(99)00569-8 }}
*{{cite journal | author=Miyachi T, Maruyama H, Kitamura T, ''et al.'' |title=Structure and regulation of the human NeuroD (BETA2/BHF1) gene. |journal=Brain Res. Mol. Brain Res. |volume=69 |issue= 2 |pages= 223-31 |year= 1999 |pmid= 10366743 |doi= }}
* {{cite journal | vauthors = Malecki MT, Jhala US, Antonellis A, Fields L, Doria A, Orban T, Saad M, Warram JH, Montminy M, Krolewski AS | title = Mutations in NEUROD1 are associated with the development of type 2 diabetes mellitus | journal = Nature Genetics | volume = 23 | issue = 3 | pages = 323–8 | date = Nov 1999 | pmid = 10545951 | doi = 10.1038/15500 }}
*{{cite journal | author=Noma T, Yoon YS, Yamashiro Y, ''et al.'' |title=Regulation of NeuroD expression by activation of the protein kinase-C pathway in Y79 human retinoblastoma cells. |journal=Neurosci. Lett. |volume=272 |issue= 1 |pages= 45-8 |year= 1999 |pmid= 10507539 |doi= }}
* {{cite journal | vauthors = Glick E, Leshkowitz D, Walker MD | title = Transcription factor BETA2 acts cooperatively with E2A and PDX1 to activate the insulin gene promoter | journal = The Journal of Biological Chemistry | volume = 275 | issue = 3 | pages = 2199–204 | date = Jan 2000 | pmid = 10636926 | doi = 10.1074/jbc.275.3.2199 }}
*{{cite journal | author=Malecki MT, Jhala US, Antonellis A, ''et al.'' |title=Mutations in NEUROD1 are associated with the development of type 2 diabetes mellitus. |journal=Nat. Genet. |volume=23 |issue= 3 |pages= 323-8 |year= 1999 |pmid= 10545951 |doi= 10.1038/15500 }}
* {{cite journal | vauthors = Onions J, Hermann S, Grundström T | title = A novel type of calmodulin interaction in the inhibition of basic helix-loop-helix transcription factors | journal = Biochemistry | volume = 39 | issue = 15 | pages = 4366–74 | date = Apr 2000 | pmid = 10757985 | doi = 10.1021/bi992533u }}
*{{cite journal | author=Glick E, Leshkowitz D, Walker MD |title=Transcription factor BETA2 acts cooperatively with E2A and PDX1 to activate the insulin gene promoter. |journal=J. Biol. Chem. |volume=275 |issue= 3 |pages= 2199-204 |year= 2000 |pmid= 10636926 |doi= }}
* {{cite journal | vauthors = Mochizuki M, Amemiya S, Kobayashi K, Kobayashi K, Ishihara T, Aya M, Kato K, Kasuga A, Nakazawa S | title = The association of Ala45Thr polymorphism in NeuroD with child-onset Type 1a diabetes in Japanese | journal = Diabetes Research and Clinical Practice | volume = 55 | issue = 1 | pages = 11–7 | date = Jan 2002 | pmid = 11755474 | doi = 10.1016/S0168-8227(01)00242-X }}
*{{cite journal | author=Onions J, Hermann S, Grundström T |title=A novel type of calmodulin interaction in the inhibition of basic helix-loop-helix transcription factors. |journal=Biochemistry |volume=39 |issue= 15 |pages= 4366-74 |year= 2000 |pmid= 10757985 |doi= }}
* {{cite journal | vauthors = Ratineau C, Petry MW, Mutoh H, Leiter AB | title = Cyclin D1 represses the basic helix-loop-helix transcription factor, BETA2/NeuroD | journal = The Journal of Biological Chemistry | volume = 277 | issue = 11 | pages = 8847–53 | date = Mar 2002 | pmid = 11788592 | doi = 10.1074/jbc.M110747200 }}
*{{cite journal | author=Mochizuki M, Amemiya S, Kobayashi K, ''et al.'' |title=The association of Ala45Thr polymorphism in NeuroD with child-onset Type 1a diabetes in Japanese. |journal=Diabetes Res. Clin. Pract. |volume=55 |issue= 1 |pages= 11-7 |year= 2002 |pmid= 11755474 |doi= }}
* {{cite journal | vauthors = Westerman BA, Poutsma A, Maruyama K, Schrijnemakers HF, van Wijk IJ, Oudejans CB | title = The proneural genes NEUROD1 and NEUROD2 are expressed during human trophoblast invasion | journal = Mechanisms of Development | volume = 113 | issue = 1 | pages = 85–90 | date = Apr 2002 | pmid = 11900979 | doi = 10.1016/S0925-4773(01)00665-7 }}
*{{cite journal | author=Ratineau C, Petry MW, Mutoh H, Leiter AB |title=Cyclin D1 represses the basic helix-loop-helix transcription factor, BETA2/NeuroD. |journal=J. Biol. Chem. |volume=277 |issue= 11 |pages= 8847-53 |year= 2002 |pmid= 11788592 |doi= 10.1074/jbc.M110747200 }}
* {{cite journal | vauthors = Kanatsuka A, Tokuyama Y, Nozaki O, Matsui K, Egashira T | title = Beta-cell dysfunction in late-onset diabetic subjects carrying homozygous mutation in transcription factors NeuroD1 and Pax4 | journal = Metabolism | volume = 51 | issue = 9 | pages = 1161–5 | date = Sep 2002 | pmid = 12200761 | doi = 10.1053/meta.2002.34707 }}
*{{cite journal | author=Westerman BA, Poutsma A, Maruyama K, ''et al.'' |title=The proneural genes NEUROD1 and NEUROD2 are expressed during human trophoblast invasion. |journal=Mech. Dev. |volume=113 |issue= 1 |pages= 85-90 |year= 2002 |pmid= 11900979 |doi= }}
*{{cite journal | author=Kanatsuka A, Tokuyama Y, Nozaki O, ''et al.'' |title=Beta-cell dysfunction in late-onset diabetic subjects carrying homozygous mutation in transcription factors NeuroD1 and Pax4. |journal=Metab. Clin. Exp. |volume=51 |issue= 9 |pages= 1161-5 |year= 2002 |pmid= 12200761 |doi= }}
}}
{{refend}}
{{refend}}


== External links ==
== External links ==
* {{MeshName|NEUROD1+protein,+human}}
* {{MeshName|NEUROD1+protein,+human}}
{{NLM content}}
{{Transcription factors|g1}}


{{DEFAULTSORT:Neurod1}}
[[Category:Transcription factors]]
[[Category:Human proteins]]


{{gene-2-stub}}
{{gene-2-stub}}
{{NLM content}}
{{Transcription factors}}
[[Category:Transcription factors]]
{{WikiDoc Sources}}

Revision as of 00:27, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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View/Edit Human

Neurogenic differentiation 1 (NeuroD1), also called β2,[1] is a transcription factor of the NeuroD-type. It is encoded by the human gene NEUROD1.

It is a member of the NeuroD family of basic helix-loop-helix (bHLH) transcription factors. The protein forms heterodimers with other bHLH proteins and activates transcription of genes that contain a specific DNA sequence known as the E-box. It regulates expression of the insulin gene, and mutations in this gene result in type II diabetes mellitus.[2]

Interactions

NEUROD1 has been shown to interact with MAP3K10,[3] MAFA[4] and Cyclin D1.[5]

References

  1. ↑ Poulin G, Turgeon B, Drouin J (Nov 1997). "NeuroD1/beta2 contributes to cell-specific transcription of the proopiomelanocortin gene". Molecular and Cellular Biology. 17 (11): 6673–82. doi:10.1128/mcb.17.11.6673. PMC 232521. PMID 9343431.
  2. ↑ "Entrez Gene: NEUROD1 neurogenic differentiation 1".
  3. ↑ Marcora E, Gowan K, Lee JE (Aug 2003). "Stimulation of NeuroD activity by huntingtin and huntingtin-associated proteins HAP1 and MLK2". Proceedings of the National Academy of Sciences of the United States of America. 100 (16): 9578–83. doi:10.1073/pnas.1133382100. PMC 170960. PMID 12881483.
  4. ↑ Zhao L, Guo M, Matsuoka TA, Hagman DK, Parazzoli SD, Poitout V, Stein R (Mar 2005). "The islet beta cell-enriched MafA activator is a key regulator of insulin gene transcription". The Journal of Biological Chemistry. 280 (12): 11887–94. doi:10.1074/jbc.M409475200. PMID 15665000.
  5. ↑ Ratineau C, Petry MW, Mutoh H, Leiter AB (Mar 2002). "Cyclin D1 represses the basic helix-loop-helix transcription factor, BETA2/NeuroD". The Journal of Biological Chemistry. 277 (11): 8847–53. doi:10.1074/jbc.M110747200. PMID 11788592.

Further reading

  • Fajans SS, Bell GI, Polonsky KS (Sep 2001). "Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young". The New England Journal of Medicine. 345 (13): 971–80. doi:10.1056/NEJMra002168. PMID 11575290.
  • Cho JH, Tsai MJ (Aug 2004). "The role of BETA2/NeuroD1 in the development of the nervous system". Molecular Neurobiology. 30 (1): 35–47. doi:10.1385/MN:30:1:035. PMID 15247487.
  • Chae JH, Stein GH, Lee JE (Dec 2004). "NeuroD: the predicted and the surprising". Molecules and Cells. 18 (3): 271–88. PMID 15650322.
  • Tamimi R, Steingrimsson E, Copeland NG, Dyer-Montgomery K, Lee JE, Hernandez R, Jenkins NA, Tapscott SJ (Jun 1996). "The NEUROD gene maps to human chromosome 2q32 and mouse chromosome 2". Genomics. 34 (3): 418–21. doi:10.1006/geno.1996.0306. PMID 8786144.
  • Yokoyama M, Nishi Y, Miyamoto Y, Nakamura M, Akiyama K, Matsubara K, Okubo K (Nov 1996). "Molecular cloning of a human neuroD from a neuroblastoma cell line specifically expressed in the fetal brain and adult cerebellum". Brain Research. Molecular Brain Research. 42 (1): 135–9. doi:10.1016/S0169-328X(96)00154-4. PMID 8915591.
  • Yokoyama M, Nishi Y, Yoshii J, Okubo K, Matsubara K (Oct 1996). "Identification and cloning of neuroblastoma-specific and nerve tissue-specific genes through compiled expression profiles". DNA Research. 3 (5): 311–20. doi:10.1093/dnares/3.5.311. PMID 9039501.
  • Acharya HR, Dooley CM, Thoreson WB, Ahmad I (Apr 1997). "cDNA cloning and expression analysis of NeuroD mRNA in human retina". Biochemical and Biophysical Research Communications. 233 (2): 459–63. doi:10.1006/bbrc.1997.6483. PMID 9144558.
  • Poulin G, Turgeon B, Drouin J (Nov 1997). "NeuroD1/beta2 contributes to cell-specific transcription of the proopiomelanocortin gene". Molecular and Cellular Biology. 17 (11): 6673–82. doi:10.1128/mcb.17.11.6673. PMC 232521. PMID 9343431.
  • Furuta H, Horikawa Y, Iwasaki N, Hara M, Sussel L, Le Beau MM, Davis EM, Ogata M, Iwamoto Y, German MS, Bell GI (Aug 1998). "Beta-cell transcription factors and diabetes: mutations in the coding region of the BETA2/NeuroD1 (NEUROD1) and Nkx2.2 (NKX2B) genes are not associated with maturity-onset diabetes of the young in Japanese". Diabetes. 47 (8): 1356–8. doi:10.2337/diabetes.47.8.1356. PMID 9703340.
  • Yoon YS, Noma T, Yamashiro Y, Ito H, Nakazawa A (Jul 1998). "Molecular cloning and characterization of the gene encoding human NeuroD". Neuroscience Letters. 251 (1): 17–20. doi:10.1016/S0304-3940(98)00490-X. PMID 9714454.
  • Miyachi T, Maruyama H, Kitamura T, Nakamura S, Kawakami H (Jun 1999). "Structure and regulation of the human NeuroD (BETA2/BHF1) gene". Brain Research. Molecular Brain Research. 69 (2): 223–31. doi:10.1016/S0169-328X(99)00112-6. PMID 10366743.
  • Noma T, Yoon YS, Yamashiro Y, Fujisawa K, Nakazawa A (Sep 1999). "Regulation of NeuroD expression by activation of the protein kinase-C pathway in Y79 human retinoblastoma cells". Neuroscience Letters. 272 (1): 45–8. doi:10.1016/S0304-3940(99)00569-8. PMID 10507539.
  • Malecki MT, Jhala US, Antonellis A, Fields L, Doria A, Orban T, Saad M, Warram JH, Montminy M, Krolewski AS (Nov 1999). "Mutations in NEUROD1 are associated with the development of type 2 diabetes mellitus". Nature Genetics. 23 (3): 323–8. doi:10.1038/15500. PMID 10545951.
  • Glick E, Leshkowitz D, Walker MD (Jan 2000). "Transcription factor BETA2 acts cooperatively with E2A and PDX1 to activate the insulin gene promoter". The Journal of Biological Chemistry. 275 (3): 2199–204. doi:10.1074/jbc.275.3.2199. PMID 10636926.
  • Onions J, Hermann S, Grundström T (Apr 2000). "A novel type of calmodulin interaction in the inhibition of basic helix-loop-helix transcription factors". Biochemistry. 39 (15): 4366–74. doi:10.1021/bi992533u. PMID 10757985.
  • Mochizuki M, Amemiya S, Kobayashi K, Kobayashi K, Ishihara T, Aya M, Kato K, Kasuga A, Nakazawa S (Jan 2002). "The association of Ala45Thr polymorphism in NeuroD with child-onset Type 1a diabetes in Japanese". Diabetes Research and Clinical Practice. 55 (1): 11–7. doi:10.1016/S0168-8227(01)00242-X. PMID 11755474.
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