Multiple endocrine neoplasia type 2 history and symptoms: Difference between revisions
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==History and Symptoms== | ==History and Symptoms== | ||
===Constitutional Symptoms=== | ===Constitutional Symptoms=== | ||
* Tall, thin, "[[Marfan syndrome|marfanoid]]" body build, in which long [[bone]]s are disproportionately elongated | * Tall, thin, "[[Marfan syndrome|marfanoid]]" body build, in which long [[bone]]s are disproportionately elongated<ref> Multiple endocrine neoplasia type 2. Wikipedia (30.09,2015)https://en.wikipedia.org/wiki/Multiple_endocrine_neoplasia_type_2 accessed on October, 2015</ref> | ||
* Masses beneath mucosal surfaces in the [[mouth]], [[lip]]s, and [[eye]]s. Numerous yellowish-white, sessile, painless nodules on the [[lip]]s or [[tongue]], with deeper lesions having normal coloration. There may be enough [[neuroma]]s in the body of the [[lip]]s to produce enlargement and a "blubbery lip" appearance. Similar nodules may be seen on the [[sclera]] and [[eyelid]]s. | * Masses beneath mucosal surfaces in the [[mouth]], [[lip]]s, and [[eye]]s. Numerous yellowish-white, sessile, painless nodules on the [[lip]]s or [[tongue]], with deeper lesions having normal coloration. There may be enough [[neuroma]]s in the body of the [[lip]]s to produce enlargement and a "blubbery lip" appearance. Similar nodules may be seen on the [[sclera]] and [[eyelid]]s. | ||
* Low [[muscle]] mass, sometimes with [[myopathy]] | * Low [[muscle]] mass, sometimes with [[myopathy]] | ||
Revision as of 02:55, 5 October 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]
Overview
Symptoms of multiple endocrine neoplasia type 2 include headache, hoarseness of voice, palpitations, anxiety and weight loss.
History and Symptoms
Constitutional Symptoms
- Tall, thin, "marfanoid" body build, in which long bones are disproportionately elongated[1]
- Masses beneath mucosal surfaces in the mouth, lips, and eyes. Numerous yellowish-white, sessile, painless nodules on the lips or tongue, with deeper lesions having normal coloration. There may be enough neuromas in the body of the lips to produce enlargement and a "blubbery lip" appearance. Similar nodules may be seen on the sclera and eyelids.
- Low muscle mass, sometimes with myopathy
- Weight loss
- Delayed puberty
- Sweating
- Hand tremor
- Sleeping difficulty
- Lethargy
Gastrointestinal Symptoms
Respiratory Symptoms
Cardiovascular Symptoms
- Chest pain
- Palpitations
- Anxiety often resembling that of a panic attack
- Diaphoresis
Neurologic Symptoms
Ophthalmology Symptoms
- Dry eyes or lack of tears, which is an especially helpful sign in children
References
- ↑ Multiple endocrine neoplasia type 2. Wikipedia (30.09,2015)https://en.wikipedia.org/wiki/Multiple_endocrine_neoplasia_type_2 accessed on October, 2015