FOSL2: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Bot: HTTP→HTTPS)
imported>Seppi333
(bold FRA2)
 
Line 1: Line 1:
{{Infobox_gene}}
{{Infobox_gene}}
'''Fos-related antigen 2''' (FRA2) is a [[protein]] that in humans is encoded by the ''FOSL2'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: FOSL2 FOS-like antigen 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2355| accessdate = }}</ref>
'''Fos-related antigen 2''' ('''FRA2''') is a [[protein]] that in humans is encoded by the ''FOSL2'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: FOSL2 FOS-like antigen 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2355| accessdate = }}</ref>


==Function==
== Function ==
The Fos gene family consists of 4 members: [[c-Fos]], [[FOSB]], [[FOSL1]], and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation.<ref name="entrez">{{cite web | title = Entrez Gene: FOSL2 FOS-like antigen 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2355| accessdate = }}</ref>
The Fos gene family consists of 4 members: [[c-Fos]], [[FOSB]], [[FOSL1]], and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation.<ref name="entrez">{{cite web | title = Entrez Gene: FOSL2 FOS-like antigen 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2355| accessdate = }}</ref>


==See also==
== See also ==
* [[AP-1 (transcription factor)]]
* [[AP-1 (transcription factor)]]


==References==
== References ==
{{reflist}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Matsui M, Tokuhara M, Konuma Y, Nomura N, Ishizaki R | title = Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation | journal = Oncogene | volume = 5 | issue = 3 | pages = 249–55 | date = March 1990 | pmid = 2107490 | doi =  }}
| citations =
* {{cite journal | vauthors = Molven A, Houge G, Berger R | title = Chromosomal assignment of the human gene encoding the Fos-related antigen-2 (FRA2) to chromosome 2p22-p23 | journal = Genomics | volume = 38 | issue = 1 | pages = 72–5 | date = November 1996 | pmid = 8954781 | doi = 10.1006/geno.1996.0593 }}
*{{cite journal |vauthors=Matsui M, Tokuhara M, Konuma Y |title=Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation. |journal=Oncogene |volume=5 |issue= 3 |pages= 249–55 |year= 1990 |pmid= 2107490 |doi=  |display-authors=etal}}
* {{cite journal | vauthors = Outinen PA, Sood SK, Pfeifer SI, Pamidi S, Podor TJ, Li J, Weitz JI, Austin RC | title = Homocysteine-induced endoplasmic reticulum stress and growth arrest leads to specific changes in gene expression in human vascular endothelial cells | journal = Blood | volume = 94 | issue = 3 | pages = 959–67 | date = August 1999 | pmid = 10419887 | doi =  }}
*{{cite journal |vauthors=Molven A, Houge G, Berger R |title=Chromosomal assignment of the human gene encoding the Fos-related antigen-2 (FRA2) to chromosome 2p22-p23. |journal=Genomics |volume=38 |issue= 1 |pages= 72–5 |year= 1997 |pmid= 8954781 |doi= 10.1006/geno.1996.0593 }}
* {{cite journal | vauthors = Miyamoto NG, Medberry PS, Hesselgesser J, Boehlk S, Nelson PJ, Krensky AM, Perez HD | title = Interleukin-1beta induction of the chemokine RANTES promoter in the human astrocytoma line CH235 requires both constitutive and inducible transcription factors | journal = Journal of Neuroimmunology | volume = 105 | issue = 1 | pages = 78–90 | date = June 2000 | pmid = 10713367 | doi = 10.1016/S0165-5728(00)00195-8 }}
*{{cite journal |vauthors=Outinen PA, Sood SK, Pfeifer SI |title=Homocysteine-induced endoplasmic reticulum stress and growth arrest leads to specific changes in gene expression in human vascular endothelial cells. |journal=Blood |volume=94 |issue= 3 |pages= 959–67 |year= 1999 |pmid= 10419887 |doi=  |display-authors=etal}}
* {{cite journal | vauthors = Ng DC, Shafaee S, Lee D, Bikle DD | title = Requirement of an AP-1 site in the calcium response region of the involucrin promoter | journal = The Journal of Biological Chemistry | volume = 275 | issue = 31 | pages = 24080–8 | date = August 2000 | pmid = 10816578 | doi = 10.1074/jbc.M002508200 }}
*{{cite journal |vauthors=Miyamoto NG, Medberry PS, Hesselgesser J |title=Interleukin-1beta induction of the chemokine RANTES promoter in the human astrocytoma line CH235 requires both constitutive and inducible transcription factors. |journal=J. Neuroimmunol. |volume=105 |issue= 1 |pages= 78–90 |year= 2000 |pmid= 10713367 |doi=10.1016/S0165-5728(00)00195-8 |display-authors=etal}}
* {{cite journal | vauthors = Bamberger AM, Milde-Langosch K, Rössing E, Goemann C, Löning T | title = Expression pattern of the AP-1 family in endometrial cancer: correlations with cell cycle regulators | journal = Journal of Cancer Research and Clinical Oncology | volume = 127 | issue = 9 | pages = 545–50 | date = September 2001 | pmid = 11570575 | doi = 10.1007/s004320100255 }}
*{{cite journal |vauthors=Ng DC, Shafaee S, Lee D, Bikle DD |title=Requirement of an AP-1 site in the calcium response region of the involucrin promoter. |journal=J. Biol. Chem. |volume=275 |issue= 31 |pages= 24080–8 |year= 2000 |pmid= 10816578 |doi= 10.1074/jbc.M002508200 }}
* {{cite journal | vauthors = Udalova IA, Kwiatkowski D | title = Interaction of AP-1 with a cluster of NF-kappa B binding elements in the human TNF promoter region | journal = Biochemical and Biophysical Research Communications | volume = 289 | issue = 1 | pages = 25–33 | date = November 2001 | pmid = 11708771 | doi = 10.1006/bbrc.2001.5929 }}
*{{cite journal |vauthors=Bamberger AM, Milde-Langosch K, Rössing E |title=Expression pattern of the AP-1 family in endometrial cancer: correlations with cell cycle regulators. |journal=J. Cancer Res. Clin. Oncol. |volume=127 |issue= 9 |pages= 545–50 |year= 2001 |pmid= 11570575 |doi=10.1007/s004320100255 |display-authors=etal}}
* {{cite journal | vauthors = Benkoussa M, Brand C, Delmotte MH, Formstecher P, Lefebvre P | title = Retinoic acid receptors inhibit AP1 activation by regulating extracellular signal-regulated kinase and CBP recruitment to an AP1-responsive promoter | journal = Molecular and Cellular Biology | volume = 22 | issue = 13 | pages = 4522–34 | date = July 2002 | pmid = 12052862 | pmc = 133906 | doi = 10.1128/MCB.22.13.4522-4534.2002 }}
*{{cite journal |vauthors=Udalova IA, Kwiatkowski D |title=Interaction of AP-1 with a cluster of NF-kappa B binding elements in the human TNF promoter region. |journal=Biochem. Biophys. Res. Commun. |volume=289 |issue= 1 |pages= 25–33 |year= 2001 |pmid= 11708771 |doi= 10.1006/bbrc.2001.5929 }}
* {{cite journal | vauthors = Santalucía T, Christmann M, Yacoub MH, Brand NJ | title = Hypertrophic agonists induce the binding of c-Fos to an AP-1 site in cardiac myocytes: implications for the expression of GLUT1 | journal = Cardiovascular Research | volume = 59 | issue = 3 | pages = 639–48 | date = September 2003 | pmid = 14499865 | doi = 10.1016/S0008-6363(03)00472-3 }}
*{{cite journal |vauthors=Benkoussa M, Brand C, Delmotte MH |title=Retinoic acid receptors inhibit AP1 activation by regulating extracellular signal-regulated kinase and CBP recruitment to an AP1-responsive promoter. |journal=Mol. Cell. Biol. |volume=22 |issue= 13 |pages= 4522–34 |year= 2002 |pmid= 12052862 |doi=10.1128/MCB.22.13.4522-4534.2002 | pmc=133906  |display-authors=etal}}
* {{cite journal | vauthors = Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | title = Large-scale characterization of HeLa cell nuclear phosphoproteins | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 33 | pages = 12130–5 | date = August 2004 | pmid = 15302935 | pmc = 514446 | doi = 10.1073/pnas.0404720101 }}
*{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
* {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | date = November 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 }}
*{{cite journal  |vauthors=Santalucía T, Christmann M, Yacoub MH, Brand NJ |title=Hypertrophic agonists induce the binding of c-Fos to an AP-1 site in cardiac myocytes: implications for the expression of GLUT1. |journal=Cardiovasc. Res. |volume=59 |issue= 3 |pages= 639–48 |year= 2004 |pmid= 14499865 |doi=10.1016/S0008-6363(03)00472-3 }}
*{{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
*{{cite journal  |vauthors=Beausoleil SA, Jedrychowski M, Schwartz D |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101  | pmc=514446 |display-authors=etal}}
*{{cite journal  |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 |display-authors=etal}}
*{{cite journal  |vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal}}
*{{cite journal |vauthors=Olsen JV, Blagoev B, Gnad F |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |display-authors=etal}}
}}
{{refend}}
{{refend}}


Line 39: Line 32:


{{Transcription factors|g1}}
{{Transcription factors|g1}}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


[[Category:Transcription factors]]
[[Category:Transcription factors]]


{{gene-2-stub}}
{{gene-2-stub}}

Latest revision as of 21:56, 2 January 2018

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Fos-related antigen 2 (FRA2) is a protein that in humans is encoded by the FOSL2 gene.[1]

Function

The Fos gene family consists of 4 members: c-Fos, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation.[1]

See also

References

  1. ↑ 1.0 1.1 "Entrez Gene: FOSL2 FOS-like antigen 2".

Further reading

  • Matsui M, Tokuhara M, Konuma Y, Nomura N, Ishizaki R (March 1990). "Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation". Oncogene. 5 (3): 249–55. PMID 2107490.
  • Molven A, Houge G, Berger R (November 1996). "Chromosomal assignment of the human gene encoding the Fos-related antigen-2 (FRA2) to chromosome 2p22-p23". Genomics. 38 (1): 72–5. doi:10.1006/geno.1996.0593. PMID 8954781.
  • Outinen PA, Sood SK, Pfeifer SI, Pamidi S, Podor TJ, Li J, Weitz JI, Austin RC (August 1999). "Homocysteine-induced endoplasmic reticulum stress and growth arrest leads to specific changes in gene expression in human vascular endothelial cells". Blood. 94 (3): 959–67. PMID 10419887.
  • Miyamoto NG, Medberry PS, Hesselgesser J, Boehlk S, Nelson PJ, Krensky AM, Perez HD (June 2000). "Interleukin-1beta induction of the chemokine RANTES promoter in the human astrocytoma line CH235 requires both constitutive and inducible transcription factors". Journal of Neuroimmunology. 105 (1): 78–90. doi:10.1016/S0165-5728(00)00195-8. PMID 10713367.
  • Ng DC, Shafaee S, Lee D, Bikle DD (August 2000). "Requirement of an AP-1 site in the calcium response region of the involucrin promoter". The Journal of Biological Chemistry. 275 (31): 24080–8. doi:10.1074/jbc.M002508200. PMID 10816578.
  • Bamberger AM, Milde-Langosch K, Rössing E, Goemann C, Löning T (September 2001). "Expression pattern of the AP-1 family in endometrial cancer: correlations with cell cycle regulators". Journal of Cancer Research and Clinical Oncology. 127 (9): 545–50. doi:10.1007/s004320100255. PMID 11570575.
  • Udalova IA, Kwiatkowski D (November 2001). "Interaction of AP-1 with a cluster of NF-kappa B binding elements in the human TNF promoter region". Biochemical and Biophysical Research Communications. 289 (1): 25–33. doi:10.1006/bbrc.2001.5929. PMID 11708771.
  • Benkoussa M, Brand C, Delmotte MH, Formstecher P, Lefebvre P (July 2002). "Retinoic acid receptors inhibit AP1 activation by regulating extracellular signal-regulated kinase and CBP recruitment to an AP1-responsive promoter". Molecular and Cellular Biology. 22 (13): 4522–34. doi:10.1128/MCB.22.13.4522-4534.2002. PMC 133906. PMID 12052862.
  • Santalucía T, Christmann M, Yacoub MH, Brand NJ (September 2003). "Hypertrophic agonists induce the binding of c-Fos to an AP-1 site in cardiac myocytes: implications for the expression of GLUT1". Cardiovascular Research. 59 (3): 639–48. doi:10.1016/S0008-6363(03)00472-3. PMID 14499865.
  • Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


Retrieved from "https://www.wikidoc.org/index.php?title=FOSL2&oldid=1531699"