FOSL2: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Fos-related antigen 2''' (FRA2) is a [[protein]] that in humans is encoded by the ''FOSL2'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: FOSL2 FOS-like antigen 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2355| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = FOS-like antigen 2
| HGNCid = 3798
| Symbol = FOSL2
| AltSymbols =; FLJ23306; FRA2
| OMIM = 601575
| ECnumber = 
| Homologene = 3845
| MGIid = 102858
| GeneAtlas_image1 = PBB_GE_FOSL2_205409_at_tn.png
| GeneAtlas_image2 = PBB_GE_FOSL2_218880_at_tn.png
| GeneAtlas_image3 = PBB_GE_FOSL2_218881_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046983 |text = protein dimerization activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006357 |text = regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0008219 |text = cell death}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2355
    | Hs_Ensembl = ENSG00000075426
    | Hs_RefseqProtein = NP_005244
    | Hs_RefseqmRNA = NM_005253
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 28469173
    | Hs_GenLoc_end = 28493683
    | Hs_Uniprot = P15408
    | Mm_EntrezGene = 14284
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = NM_008037
    | Mm_RefseqProtein = NP_032063
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''FOS-like antigen 2''', also known as '''FOSL2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: FOSL2 FOS-like antigen 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2355| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
==Function==
{{PBB_Summary
The Fos gene family consists of 4 members: [[c-Fos]], [[FOSB]], [[FOSL1]], and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation.<ref name="entrez">{{cite web | title = Entrez Gene: FOSL2 FOS-like antigen 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2355| accessdate = }}</ref>
| section_title =  
| summary_text = The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation.<ref name="entrez">{{cite web | title = Entrez Gene: FOSL2 FOS-like antigen 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2355| accessdate = }}</ref>
}}


==See also==
==See also==
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==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
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{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Matsui M, Tokuhara M, Konuma Y, ''et al.'' |title=Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation. |journal=Oncogene |volume=5 |issue= 3 |pages= 249-55 |year= 1990 |pmid= 2107490 |doi=  }}
*{{cite journal  |vauthors=Matsui M, Tokuhara M, Konuma Y |title=Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation. |journal=Oncogene |volume=5 |issue= 3 |pages= 249–55 |year= 1990 |pmid= 2107490 |doi=  |display-authors=etal}}
*{{cite journal  | author=Molven A, Houge G, Berger R |title=Chromosomal assignment of the human gene encoding the Fos-related antigen-2 (FRA2) to chromosome 2p22-p23. |journal=Genomics |volume=38 |issue= 1 |pages= 72-5 |year= 1997 |pmid= 8954781 |doi= 10.1006/geno.1996.0593 }}
*{{cite journal  |vauthors=Molven A, Houge G, Berger R |title=Chromosomal assignment of the human gene encoding the Fos-related antigen-2 (FRA2) to chromosome 2p22-p23. |journal=Genomics |volume=38 |issue= 1 |pages= 72–5 |year= 1997 |pmid= 8954781 |doi= 10.1006/geno.1996.0593 }}
*{{cite journal  | author=Outinen PA, Sood SK, Pfeifer SI, ''et al.'' |title=Homocysteine-induced endoplasmic reticulum stress and growth arrest leads to specific changes in gene expression in human vascular endothelial cells. |journal=Blood |volume=94 |issue= 3 |pages= 959-67 |year= 1999 |pmid= 10419887 |doi=  }}
*{{cite journal  |vauthors=Outinen PA, Sood SK, Pfeifer SI |title=Homocysteine-induced endoplasmic reticulum stress and growth arrest leads to specific changes in gene expression in human vascular endothelial cells. |journal=Blood |volume=94 |issue= 3 |pages= 959–67 |year= 1999 |pmid= 10419887 |doi=  |display-authors=etal}}
*{{cite journal  | author=Miyamoto NG, Medberry PS, Hesselgesser J, ''et al.'' |title=Interleukin-1beta induction of the chemokine RANTES promoter in the human astrocytoma line CH235 requires both constitutive and inducible transcription factors. |journal=J. Neuroimmunol. |volume=105 |issue= 1 |pages= 78-90 |year= 2000 |pmid= 10713367 |doi=  }}
*{{cite journal  |vauthors=Miyamoto NG, Medberry PS, Hesselgesser J |title=Interleukin-1beta induction of the chemokine RANTES promoter in the human astrocytoma line CH235 requires both constitutive and inducible transcription factors. |journal=J. Neuroimmunol. |volume=105 |issue= 1 |pages= 78–90 |year= 2000 |pmid= 10713367 |doi=10.1016/S0165-5728(00)00195-8 |display-authors=etal}}
*{{cite journal  | author=Ng DC, Shafaee S, Lee D, Bikle DD |title=Requirement of an AP-1 site in the calcium response region of the involucrin promoter. |journal=J. Biol. Chem. |volume=275 |issue= 31 |pages= 24080-8 |year= 2000 |pmid= 10816578 |doi= 10.1074/jbc.M002508200 }}
*{{cite journal  |vauthors=Ng DC, Shafaee S, Lee D, Bikle DD |title=Requirement of an AP-1 site in the calcium response region of the involucrin promoter. |journal=J. Biol. Chem. |volume=275 |issue= 31 |pages= 24080–8 |year= 2000 |pmid= 10816578 |doi= 10.1074/jbc.M002508200 }}
*{{cite journal  | author=Bamberger AM, Milde-Langosch K, Rössing E, ''et al.'' |title=Expression pattern of the AP-1 family in endometrial cancer: correlations with cell cycle regulators. |journal=J. Cancer Res. Clin. Oncol. |volume=127 |issue= 9 |pages= 545-50 |year= 2001 |pmid= 11570575 |doi=  }}
*{{cite journal  |vauthors=Bamberger AM, Milde-Langosch K, Rössing E |title=Expression pattern of the AP-1 family in endometrial cancer: correlations with cell cycle regulators. |journal=J. Cancer Res. Clin. Oncol. |volume=127 |issue= 9 |pages= 545–50 |year= 2001 |pmid= 11570575 |doi=10.1007/s004320100255 |display-authors=etal}}
*{{cite journal  | author=Udalova IA, Kwiatkowski D |title=Interaction of AP-1 with a cluster of NF-kappa B binding elements in the human TNF promoter region. |journal=Biochem. Biophys. Res. Commun. |volume=289 |issue= 1 |pages= 25-33 |year= 2001 |pmid= 11708771 |doi= 10.1006/bbrc.2001.5929 }}
*{{cite journal  |vauthors=Udalova IA, Kwiatkowski D |title=Interaction of AP-1 with a cluster of NF-kappa B binding elements in the human TNF promoter region. |journal=Biochem. Biophys. Res. Commun. |volume=289 |issue= 1 |pages= 25–33 |year= 2001 |pmid= 11708771 |doi= 10.1006/bbrc.2001.5929 }}
*{{cite journal  | author=Benkoussa M, Brand C, Delmotte MH, ''et al.'' |title=Retinoic acid receptors inhibit AP1 activation by regulating extracellular signal-regulated kinase and CBP recruitment to an AP1-responsive promoter. |journal=Mol. Cell. Biol. |volume=22 |issue= 13 |pages= 4522-34 |year= 2002 |pmid= 12052862 |doi=  }}
*{{cite journal  |vauthors=Benkoussa M, Brand C, Delmotte MH |title=Retinoic acid receptors inhibit AP1 activation by regulating extracellular signal-regulated kinase and CBP recruitment to an AP1-responsive promoter. |journal=Mol. Cell. Biol. |volume=22 |issue= 13 |pages= 4522–34 |year= 2002 |pmid= 12052862 |doi=10.1128/MCB.22.13.4522-4534.2002  | pmc=133906 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Santalucía T, Christmann M, Yacoub MH, Brand NJ |title=Hypertrophic agonists induce the binding of c-Fos to an AP-1 site in cardiac myocytes: implications for the expression of GLUT1. |journal=Cardiovasc. Res. |volume=59 |issue= 3 |pages= 639-48 |year= 2004 |pmid= 14499865 |doi=  }}
*{{cite journal  |vauthors=Santalucía T, Christmann M, Yacoub MH, Brand NJ |title=Hypertrophic agonists induce the binding of c-Fos to an AP-1 site in cardiac myocytes: implications for the expression of GLUT1. |journal=Cardiovasc. Res. |volume=59 |issue= 3 |pages= 639–48 |year= 2004 |pmid= 14499865 |doi=10.1016/S0008-6363(03)00472-3 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  |vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
*{{cite journal  | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
*{{cite journal  |vauthors=Beausoleil SA, Jedrychowski M, Schwartz D |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  |vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal}}
*{{cite journal  | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal  |vauthors=Olsen JV, Blagoev B, Gnad F |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |display-authors=etal}}
}}
}}
{{refend}}
{{refend}}
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== External links ==
== External links ==
* {{MeshName|FOSL2+protein,+human}}
* {{MeshName|FOSL2+protein,+human}}
* {{FactorBook|FOSL2}}
{{NLM content}}
{{Transcription factors|g1}}
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{{NLM content}}
{{protein-stub}}
{{Transcription factors}}
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}
 
 
{{gene-2-stub}}

Revision as of 04:53, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Fos-related antigen 2 (FRA2) is a protein that in humans is encoded by the FOSL2 gene.[1]

Function

The Fos gene family consists of 4 members: c-Fos, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation.[1]

See also

References

  1. ↑ 1.0 1.1 "Entrez Gene: FOSL2 FOS-like antigen 2".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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