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{{Infobox_gene}}
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'''Transcription regulator protein BACH2''' is a [[protein]] that in humans is encoded by the ''BACH2'' [[gene]].<ref name="pmid10949928">{{cite journal | vauthors = Sasaki S, Ito E, Toki T, Maekawa T, Kanezaki R, Umenai T, Muto A, Nagai H, Kinoshita T, Yamamoto M, Inazawa J, Taketo MM, Nakahata T, Igarashi K, Yokoyama M | title = Cloning and expression of human B cell-specific transcription factor BACH2 mapped to chromosome 6q15 | journal = Oncogene | volume = 19 | issue = 33 | pages = 3739–49 | date = Aug 2000 | pmid = 10949928 | pmc =  | doi = 10.1038/sj.onc.1203716 }}</ref><ref name="pmid12829606">{{cite journal | vauthors = Kamio T, Toki T, Kanezaki R, Sasaki S, Tandai S, Terui K, Ikebe D, Igarashi K, Ito E | title = B-cell-specific transcription factor BACH2 modifies the cytotoxic effects of anticancer drugs | journal = Blood | volume = 102 | issue = 9 | pages = 3317–22 | date = Nov 2003 | pmid = 12829606 | pmc =  | doi = 10.1182/blood-2002-12-3656 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=60468| accessdate = }}</ref> It contains a [[BTB/POZ domain]] at its N-terminus which forms a disulphide-linked dimer <ref>{{cite journal | vauthors = Rosbrook GO, Stead MA, Carr SB, Wright SC | title = The structure of the Bach2 POZ-domain dimer reveals an intersubunit disulfide bond | journal = Acta Crystallographica Section D | volume = 68 | issue = Pt 1 | pages = 26–34 | date = Jan 2012 | pmid = 22194330 | pmc = | doi = 10.1107/S0907444911048335 }}</ref> and a [[BZIP Maf|bZip_Maf]] domain at the C-terminus.
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==Model organisms==
{{GNF_Protein_box
[[Model organism]]s have been used in the study of BACH2 function. A conditional [[knockout mouse]] line called ''Bach2<sup>tm1a(EUCOMM)Wtsi</sup>'' was generated at the [[Wellcome Trust Sanger Institute]].<ref name="mgp_reference">{{cite journal |title=The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice |author=Gerdin AK |year=2010 |journal=Acta Ophthalmologica|volume=88 |pages=925–7|doi=10.1111/j.1755-3768.2010.4142.x }}</ref> Male and female animals underwent a standardized [[phenotypic screen]]<ref name="IMPCsearch_ref">{{cite web |url=http://www.mousephenotype.org/data/search?q=Bach2#fq=*:*&facet=gene |title=International Mouse Phenotyping Consortium}}</ref> to determine the effects of deletion.<ref name="pmid21677750">{{cite journal | vauthors = Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A | title = A conditional knockout resource for the genome-wide study of mouse gene function | journal = Nature | volume = 474 | issue = 7351 | pages = 337–42 | date = Jun 2011 | pmid = 21677750 | pmc = 3572410 | doi = 10.1038/nature10163 }}</ref><ref name="mouse_library">{{cite journal | vauthors = Dolgin E | title = Mouse library set to be knockout | journal = Nature | volume = 474 | issue = 7351 | pages = 262–3 | date = Jun 2011 | pmid = 21677718 | doi = 10.1038/474262a }}</ref><ref name="mouse_for_all_reasons">{{cite journal | vauthors = Collins FS, Rossant J, Wurst W | title = A mouse for all reasons | journal = Cell | volume = 128 | issue = 1 | pages = 9–13 | date = Jan 2007 | pmid = 17218247 | doi = 10.1016/j.cell.2006.12.018 }}</ref><ref name="pmid23870131">{{cite journal | vauthors = White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP | title = Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes | journal = Cell | volume = 154 | issue = 2 | pages = 452–64 | date = Jul 2013 | pmid = 23870131 | pmc = 3717207 | doi = 10.1016/j.cell.2013.06.022 }}</ref> Additional screens performed: - In-depth immunological phenotyping<ref name="iii_ref">{{cite web |url= http://www.immunophenotyping.org/data/search?keys=Bach2&field_gene_construct_tid=All |title=Infection and Immunity Immunophenotyping (3i) Consortium}}</ref> - in-depth bone and cartilage phenotyping<ref name="obcd_ref">{{cite web |url=http://www.boneandcartilage.com/ |title=OBCD Consortium}}</ref>
| image =
{| class="wikitable sortable collapsible collapsed" border="1" cellpadding="2" style="float: left;" |
| image_source =
|+ ''Bach2'' knockout mouse phenotype
| PDB =  
|-
| Name = BTB and CNC homology 1, basic leucine zipper transcription factor 2
! Characteristic!! Phenotype
| HGNCid = 14078
|-
| Symbol = BACH2
| colspan=2; style="text-align: center;" | All data available at.<ref name="IMPCsearch_ref"/><ref name="iii_ref" />
| AltSymbols =;
| OMIM = 605394
| ECnumber =
| Homologene = 7240
| MGIid =
| GeneAtlas_image1 = PBB_GE_BACH2_221234_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046983 |text = protein dimerization activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 60468
    | Hs_Ensembl = ENSG00000112182
    | Hs_RefseqProtein = NP_068585
    | Hs_RefseqmRNA = NM_021813
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 90692969
    | Hs_GenLoc_end = 91063182
    | Hs_Uniprot = Q9BYV9
    | Mm_EntrezGene =
    | Mm_Ensembl =
    | Mm_RefseqmRNA =
    | Mm_RefseqProtein =
    | Mm_GenLoc_db =
    | Mm_GenLoc_chr =
    | Mm_GenLoc_start =   
    | Mm_GenLoc_end =
    | Mm_Uniprot =
  }}
}}
'''BTB and CNC homology 1, basic leucine zipper transcription factor 2''', also known as '''BACH2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=60468| accessdate = }}</ref>


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|-
{{PBB_Summary
| Peripheral blood leukocytes 6 Weeks || bgcolor="#C40000"|Abnormal
| section_title =  
| summary_text =
}}


==References==
|-
{{reflist|2}}
| ''[[Haematology]]'' 6 Weeks || bgcolor="#C40000"|Abnormal
==Further reading==
 
{{refbegin | 2}}
|-
{{PBB_Further_reading
| Insulin || bgcolor="#488ED3"|Normal
| citations =
 
*{{cite journal | author=Oyake T, Itoh K, Motohashi H, ''et al.'' |title=Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site. |journal=Mol. Cell. Biol. |volume=16 |issue= 11 |pages= 6083-95 |year= 1996 |pmid= 8887638 |doi= }}
|-
*{{cite journal | author=Kobayashi A, Yamagiwa H, Hoshino H, ''et al.'' |title=A combinatorial code for gene expression generated by transcription factor Bach2 and MAZR (MAZ-related factor) through the BTB/POZ domain. |journal=Mol. Cell. Biol. |volume=20 |issue= 5 |pages= 1733-46 |year= 2000 |pmid= 10669750 |doi= }}
| Homozygous viability at P14 || bgcolor="#488ED3"|Normal
*{{cite journal | author=Hoshino H, Kobayashi A, Yoshida M, ''et al.'' |title=Oxidative stress abolishes leptomycin B-sensitive nuclear export of transcription repressor Bach2 that counteracts activation of Maf recognition element. |journal=J. Biol. Chem. |volume=275 |issue= 20 |pages= 15370-6 |year= 2000 |pmid= 10809773 |doi=  }}
 
*{{cite journal  | author=Sasaki S, Ito E, Toki T, ''et al.'' |title=Cloning and expression of human B cell-specific transcription factor BACH2 mapped to chromosome 6q15. |journal=Oncogene |volume=19 |issue= 33 |pages= 3739-49 |year= 2000 |pmid= 10949928 |doi= 10.1038/sj.onc.1203716 }}
|-
*{{cite journal | author=Vieira SA, Deininger MW, Sorour A, ''et al.'' |title=Transcription factor BACH2 is transcriptionally regulated by the BCR/ABL oncogene. |journal=Genes Chromosomes Cancer |volume=32 |issue= 4 |pages= 353-63 |year= 2002 |pmid= 11746976 |doi= }}
| Homozygous Fertility || bgcolor="#488ED3"|Normal
*{{cite journal | author=Muto A, Tashiro S, Tsuchiya H, ''et al.'' |title=Activation of Maf/AP-1 repressor Bach2 by oxidative stress promotes apoptosis and its interaction with promyelocytic leukemia nuclear bodies. |journal=J. Biol. Chem. |volume=277 |issue= 23 |pages= 20724-33 |year= 2002 |pmid= 11923289 |doi= 10.1074/jbc.M112003200 }}
 
*{{cite journal | author=Kamio T, Toki T, Kanezaki R, ''et al.'' |title=B-cell-specific transcription factor BACH2 modifies the cytotoxic effects of anticancer drugs. |journal=Blood |volume=102 |issue= 9 |pages= 3317-22 |year= 2004 |pmid= 12829606 |doi= 10.1182/blood-2002-12-3656 }}
|-
*{{cite journal  | author=Mungall AJ, Palmer SA, Sims SK, ''et al.'' |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805-11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
| Body weight || bgcolor="#488ED3"|Normal
*{{cite journal  | author=Takakuwa T, Luo WJ, Ham MF, ''et al.'' |title=Integration of Epstein-Barr virus into chromosome 6q15 of Burkitt lymphoma cell line (Raji) induces loss of BACH2 expression. |journal=Am. J. Pathol. |volume=164 |issue= 3 |pages= 967-74 |year= 2004 |pmid= 14982850 |doi= }}
 
*{{cite journal | author=Tashiro S, Muto A, Tanimoto K, ''et al.'' |title=Repression of PML nuclear body-associated transcription by oxidative stress-activated Bach2. |journal=Mol. Cell. Biol. |volume=24 |issue= 8 |pages= 3473-84 |year= 2004 |pmid= 15060166 |doi= }}
|-
*{{cite journal | author=Motamed-Khorasani A, Jurisica I, Letarte M, ''et al.'' |title=Differentially androgen-modulated genes in ovarian epithelial cells from BRCA mutation carriers and control patients predict ovarian cancer survival and disease progression. |journal=Oncogene |volume=26 |issue= 2 |pages= 198-214 |year= 2007 |pmid= 16832351 |doi= 10.1038/sj.onc.1209773 }}
| Neurological assessment || bgcolor="#488ED3"|Normal
*{{cite journal | author=Yoshida C, Yoshida F, Sears DE, ''et al.'' |title=Bcr-Abl signaling through the PI-3/S6 kinase pathway inhibits nuclear translocation of the transcription factor Bach2, which represses the antiapoptotic factor heme oxygenase-1. |journal=Blood |volume=109 |issue= 3 |pages= 1211-9 |year= 2007 |pmid= 17018862 |doi= 10.1182/blood-2005-12-040972 }}
 
*{{cite journal | author=Ono A, Kono K, Ikebe D, ''et al.'' |title=Nuclear positioning of the BACH2 gene in BCR-ABL positive leukemic cells. |journal=Genes Chromosomes Cancer |volume=46 |issue= 1 |pages= 67-74 |year= 2007 |pmid= 17044046 |doi= 10.1002/gcc.20390 }}
|-
*{{cite journal | author=Ikeda T, Shibata J, Yoshimura K, ''et al.'' |title=Recurrent [[HIV-1 integration]] at the BACH2 locus in resting CD4+ T cell populations during effective highly active antiretroviral therapy. |journal=J. Infect. Dis. |volume=195 |issue= 5 |pages= 716-25 |year= 2007 |pmid= 17262715 |doi= 10.1086/510915 }}
| Grip strength || bgcolor="#488ED3"|Normal
*{{cite journal | author=Hoshino H, Nishino TG, Tashiro S, ''et al.'' |title=Co-repressor SMRT and class II histone deacetylases promote Bach2 nuclear retention and formation of nuclear foci that are responsible for local transcriptional repression. |journal=J. Biochem. |volume=141 |issue= 5 |pages= 719-27 |year= 2007 |pmid= 17383980 |doi= 10.1093/jb/mvm073 }}
 
}}
|-
| [[Dysmorphology]] || bgcolor="#488ED3"|Normal
 
|-
| [[Indirect calorimetry]] || bgcolor="#488ED3"|Normal
 
|-
| [[Glucose tolerance test]] || bgcolor="#C40000"|Abnormal
 
|-
| [[Auditory brainstem response]] || bgcolor="#488ED3"|Normal
 
|-
| [[Dual-energy X-ray absorptiometry|DEXA]] || bgcolor="#C40000"|Abnormal
 
|-
| [[Radiography]] || bgcolor="#488ED3"|Normal
 
|-
| Eye morphology || bgcolor="#488ED3"|Normal
 
|-
| [[Clinical chemistry]] || bgcolor="#488ED3"|Normal
 
|-
| ''[[Haematology]]'' 16 Weeks || bgcolor="#488ED3"|Normal
 
|-
| Peripheral blood leukocytes 16 Weeks || bgcolor="#C40000"|Abnormal
 
|-
| Heart weight || bgcolor="#488ED3"|Normal
 
|-
| ''[[Salmonella]]'' infection || bgcolor="#488ED3"|Normal
 
|-
| Cytotoxic T Cell Function || bgcolor="#C40000"|Abnormal
 
|-
| Spleen Immunophenotyping || bgcolor="#C40000"|Abnormal
 
|-
| Mesenteric Lymph Node Immunophenotyping || bgcolor="#488ED3"|Normal
 
|-
| Bone Marrow Immunophenotyping || bgcolor="#488ED3"|Normal
 
|-
| Epidermal Immune Composition || bgcolor="#C40000"|Abnormal
 
|-
| Influenza Challenge || bgcolor="#488ED3"|Normal
 
|-
| Trichuris Challenge || bgcolor="#488ED3"|Normal
 
|-
|}
{{clear|left}}
 
== References ==
{{reflist|33em}}
 
== Further reading ==
{{refbegin |33em}}
* {{cite journal | vauthors = Oyake T, Itoh K, Motohashi H, Hayashi N, Hoshino H, Nishizawa M, Yamamoto M, Igarashi K | title = Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site | journal = Molecular and Cellular Biology | volume = 16 | issue = 11 | pages = 6083–95 | date = Nov 1996 | pmid = 8887638 | pmc = 231611 | doi = 10.1128/mcb.16.11.6083 }}
* {{cite journal | vauthors = Kobayashi A, Yamagiwa H, Hoshino H, Muto A, Sato K, Morita M, Hayashi N, Yamamoto M, Igarashi K | title = A combinatorial code for gene expression generated by transcription factor Bach2 and MAZR (MAZ-related factor) through the BTB/POZ domain | journal = Molecular and Cellular Biology | volume = 20 | issue = 5 | pages = 1733–46 | date = Mar 2000 | pmid = 10669750 | pmc = 85356 | doi = 10.1128/MCB.20.5.1733-1746.2000 }}
* {{cite journal | vauthors = Hoshino H, Kobayashi A, Yoshida M, Kudo N, Oyake T, Motohashi H, Hayashi N, Yamamoto M, Igarashi K | title = Oxidative stress abolishes leptomycin B-sensitive nuclear export of transcription repressor Bach2 that counteracts activation of Maf recognition element | journal = The Journal of Biological Chemistry | volume = 275 | issue = 20 | pages = 15370–6 | date = May 2000 | pmid = 10809773 | doi = 10.1074/jbc.275.20.15370 }}
* {{cite journal | vauthors = Vieira SA, Deininger MW, Sorour A, Sinclair P, Foroni L, Goldman JM, Melo JV | title = Transcription factor BACH2 is transcriptionally regulated by the BCR/ABL oncogene | journal = Genes, Chromosomes & Cancer | volume = 32 | issue = 4 | pages = 353–63 | date = Dec 2001 | pmid = 11746976 | doi = 10.1002/gcc.1200 }}
* {{cite journal | vauthors = Muto A, Tashiro S, Tsuchiya H, Kume A, Kanno M, Ito E, Yamamoto M, Igarashi K | title = Activation of Maf/AP-1 repressor Bach2 by oxidative stress promotes apoptosis and its interaction with promyelocytic leukemia nuclear bodies | journal = The Journal of Biological Chemistry | volume = 277 | issue = 23 | pages = 20724–33 | date = Jun 2002 | pmid = 11923289 | doi = 10.1074/jbc.M112003200 }}
* {{cite journal | vauthors = Takakuwa T, Luo WJ, Ham MF, Sakane-Ishikawa F, Wada N, Aozasa K | title = Integration of Epstein-Barr virus into chromosome 6q15 of Burkitt lymphoma cell line (Raji) induces loss of BACH2 expression | journal = The American Journal of Pathology | volume = 164 | issue = 3 | pages = 967–74 | date = Mar 2004 | pmid = 14982850 | pmc = 1614712 | doi = 10.1016/S0002-9440(10)63184-7 }}
* {{cite journal | vauthors = Tashiro S, Muto A, Tanimoto K, Tsuchiya H, Suzuki H, Hoshino H, Yoshida M, Walter J, Igarashi K | title = Repression of PML nuclear body-associated transcription by oxidative stress-activated Bach2 | journal = Molecular and Cellular Biology | volume = 24 | issue = 8 | pages = 3473–84 | date = Apr 2004 | pmid = 15060166 | pmc = 381671 | doi = 10.1128/MCB.24.8.3473-3484.2004 }}
* {{cite journal | vauthors = Motamed-Khorasani A, Jurisica I, Letarte M, Shaw PA, Parkes RK, Zhang X, Evangelou A, Rosen B, Murphy KJ, Brown TJ | title = Differentially androgen-modulated genes in ovarian epithelial cells from BRCA mutation carriers and control patients predict ovarian cancer survival and disease progression | journal = Oncogene | volume = 26 | issue = 2 | pages = 198–214 | date = Jan 2007 | pmid = 16832351 | doi = 10.1038/sj.onc.1209773 }}
* {{cite journal | vauthors = Yoshida C, Yoshida F, Sears DE, Hart SM, Ikebe D, Muto A, Basu S, Igarashi K, Melo JV | title = Bcr-Abl signaling through the PI-3/S6 kinase pathway inhibits nuclear translocation of the transcription factor Bach2, which represses the antiapoptotic factor heme oxygenase-1 | journal = Blood | volume = 109 | issue = 3 | pages = 1211–9 | date = Feb 2007 | pmid = 17018862 | doi = 10.1182/blood-2005-12-040972 }}
* {{cite journal | vauthors = Ono A, Kono K, Ikebe D, Muto A, Sun J, Kobayashi M, Ueda K, Melo JV, Igarashi K, Tashiro S | title = Nuclear positioning of the BACH2 gene in BCR-ABL positive leukemic cells | journal = Genes, Chromosomes & Cancer | volume = 46 | issue = 1 | pages = 67–74 | date = Jan 2007 | pmid = 17044046 | doi = 10.1002/gcc.20390 }}
* {{cite journal | vauthors = Ikeda T, Shibata J, Yoshimura K, Koito A, Matsushita S | title = Recurrent HIV-1 integration at the BACH2 locus in resting CD4+ T cell populations during effective highly active antiretroviral therapy | journal = The Journal of Infectious Diseases | volume = 195 | issue = 5 | pages = 716–25 | date = Mar 2007 | pmid = 17262715 | doi = 10.1086/510915 }}
* {{cite journal | vauthors = Hoshino H, Nishino TG, Tashiro S, Miyazaki M, Ohmiya Y, Igarashi K, Horinouchi S, Yoshida M | title = Co-repressor SMRT and class II histone deacetylases promote Bach2 nuclear retention and formation of nuclear foci that are responsible for local transcriptional repression | journal = Journal of Biochemistry | volume = 141 | issue = 5 | pages = 719–27 | date = May 2007 | pmid = 17383980 | doi = 10.1093/jb/mvm073 }}
{{refend}}
{{refend}}


== External links ==
== External links ==
* {{MeshName|BACH2+protein,+human}}
* {{MeshName|BACH2+protein,+human}}
* {{UCSC gene info|BACH2}}


{{NLM content}}
{{Transcription factors|g1}}


{{protein-stub}}
{{NLM content}}
{{Transcription factors}}
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}

Revision as of 02:27, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Transcription regulator protein BACH2 is a protein that in humans is encoded by the BACH2 gene.[1][2][3] It contains a BTB/POZ domain at its N-terminus which forms a disulphide-linked dimer [4] and a bZip_Maf domain at the C-terminus.

Model organisms

Model organisms have been used in the study of BACH2 function. A conditional knockout mouse line called Bach2tm1a(EUCOMM)Wtsi was generated at the Wellcome Trust Sanger Institute.[5] Male and female animals underwent a standardized phenotypic screen[6] to determine the effects of deletion.[7][8][9][10] Additional screens performed: - In-depth immunological phenotyping[11] - in-depth bone and cartilage phenotyping[12]

References

  1. ↑ Sasaki S, Ito E, Toki T, Maekawa T, Kanezaki R, Umenai T, Muto A, Nagai H, Kinoshita T, Yamamoto M, Inazawa J, Taketo MM, Nakahata T, Igarashi K, Yokoyama M (Aug 2000). "Cloning and expression of human B cell-specific transcription factor BACH2 mapped to chromosome 6q15". Oncogene. 19 (33): 3739–49. doi:10.1038/sj.onc.1203716. PMID 10949928.
  2. ↑ Kamio T, Toki T, Kanezaki R, Sasaki S, Tandai S, Terui K, Ikebe D, Igarashi K, Ito E (Nov 2003). "B-cell-specific transcription factor BACH2 modifies the cytotoxic effects of anticancer drugs". Blood. 102 (9): 3317–22. doi:10.1182/blood-2002-12-3656. PMID 12829606.
  3. ↑ "Entrez Gene: BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2".
  4. ↑ Rosbrook GO, Stead MA, Carr SB, Wright SC (Jan 2012). "The structure of the Bach2 POZ-domain dimer reveals an intersubunit disulfide bond". Acta Crystallographica Section D. 68 (Pt 1): 26–34. doi:10.1107/S0907444911048335. PMID 22194330.
  5. ↑ Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x.
  6. ↑ 6.0 6.1 "International Mouse Phenotyping Consortium".
  7. ↑ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  8. ↑ Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  9. ↑ Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
  10. ↑ White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP (Jul 2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell. 154 (2): 452–64. doi:10.1016/j.cell.2013.06.022. PMC 3717207. PMID 23870131.
  11. ↑ 11.0 11.1 "Infection and Immunity Immunophenotyping (3i) Consortium".
  12. ↑ "OBCD Consortium".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Retrieved from "https://www.wikidoc.org/index.php?title=BACH2&oldid=1421121"