Appendix cancer history and symptoms: Difference between revisions

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==Overview==
==Overview==
The majority of patients with appendix cancer are asymptomatic. Patients may complaint of vague abdominal pain or discomfort and/or girdle size changes. However, most of them are presenting with acute appendicitis due to obstruction of the appendix by the tumor, or present with malignancy complications like pseudomixuma peritonei; the rest of diagnosed cases are the result of serendipitous finding in imaging studies or discovered during laparotomy or laparoscopy because of the cancer complications.
The majority of patients with appendix cancer are [[asymptomatic]]. Patients may complain of vague [[abdominal pain]] or discomfort and/or girdle size changes. However, most of them are presenting with [[Appendicitis|acute appendicitis]] due to obstruction of the [[Vermiform appendix|appendix]] by [[tumor]], or present with [[Cancer|malignancy]] [[Complication (medicine)|complications]] like [[pseudomyxoma peritonei]]; the rest of diagnosed cases are result of serendipitous finding in i[[Imaging studies|maging studies]] or discovered during [[laparotomy]] or [[Laparoscopic surgery|laparoscopy]] because of cancer complications. The patients complains and presentation is influenced by the [[tumor]] [[histology]] and stage and ranges from a small [[asymptomatic]] [[adenocarcinoma]] to a [[Metastasis|metastatic]] [[Carcinoid Tumor|carcinoid]] tumor with liver metastasis and [[carcinoid syndrome]] signs, symptoms and [[Complication (medicine)|complications]].
 
The patients complaints and presentation is influenced by the tumor histology and stage. Range from a small asymptomatic adenocarcinoma to a metastatic carcinoid tumor with liver metastasis and carcinoid syndrome signs, symptoms and complications.  


==History and Symptoms==
==History and Symptoms==
*The majority of patients with appendix cancer are asymptomatic.
*The majority of patients with appendix cancer are [[asymptomatic]].


*Patients may complaint of vague abdominal pain or discomfort and/or girdle size changes.  
*Patients may complaint of vague [[abdominal pain]] or discomfort and/or girdle size changes.  
*However, most of them are presenting with acute appendicitis due to obstruction of the appendix by the tumor, only after pathological studies their diagnosis is revealed.
*However, most of them are presenting with [[Appendicitis|acute appendicitis]] due to obstruction of the appendix by the [[tumor]], only after [[Pathology (disambiguation)|pathological studies]] their diagnosis is revealed.<ref name="pmid26648795">Kelly KJ (2015) [https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=26648795 Management of Appendix Cancer.] ''Clin Colon Rectal Surg'' 28 (4):247-55. [http://dx.doi.org/10.1055/s-0035-1564433 DOI:10.1055/s-0035-1564433] PMID: [https://pubmed.gov/26648795 26648795]</ref>
*They may present with malignancy complications like pseudomixuma peritonei.  
*They may present with [[Cancer|malignancy]] complications like [[Pseudomyxoma peritonei|pseudomyxoma peritonei.]]
*Rest of the diagnosed cases are result of serendipitous finding in imaging studies or discovered during laparotomy or laparoscopy because of cancer complications.  
*Rest of the diagnosed cases are result of serendipitous finding in [[Imaging studies|imaging]] studies or discovered during [[laparotomy]] or [[Laparoscopic surgery|laparoscopy]] because of cancer [[Complication (medicine)|complications]].  
*The patients complaints and presentation is influenced by the tumor histology and stage. Range from a small asymptomatic adenocarcinoma to a metastatic carcinoid tumor with liver metastasis and [[carcinoid syndrome]] signs, symptoms and complications  such as diarrhea, flushing, palpitation and heart valvular problems.   
*The patients complaints and presentation is influenced by the [[tumor]] [[histology]] and [[Cancer staging|stage]]. Range from a small [[asymptomatic]] [[adenocarcinoma]] to a [[Metastasis|metastatic]] [[Carcinoid Tumor|carcinoid]] tumor with [[Liver|liver metastasis]] and [[carcinoid syndrome]] signs, symptoms and complications  such as [[Diarrhea|diarrhea,]] [[flushing]], [[palpitation]] and [[heart]] [[Valvular heart disease|valvular]] problems. <ref name="WHO">Chapter 5: Tumours of the Appendix - IARC. https://www.iarc.fr/en/publications/pdfs-online/pat-gen/bb2/bb2-chap5.pdf Accessed on January 15, 2019</ref>
:
===History===
===History===
Patients with [disease name]] may have a positive history of:
Patients with [[appendix cancer]] may have a positive history of:<ref name="WHO">Chapter 5: Tumours of the Appendix - IARC. https://www.iarc.fr/en/publications/pdfs-online/pat-gen/bb2/bb2-chap5.pdf Accessed on January 15, 2019</ref>
*[History finding 1]
:
*[History finding 2]
*[[MEN1]] Syndome
*[History finding 3]
*[[Ulcerative colitis]]
*[[Neurofibromatosis type I|Neurofibromatosis type 1]]
*[[HNPCC]]
*[[Smoking]]


===Common Symptoms===
===Common Symptoms===
* Symptoms of appendix cancer may include the following:
* Common symptoms of appendix cancer are as follows:
:* Chronic [[abdominal pain]]
**Asymptomatic
:** Periumbilical
**Vague chronic [[abdominal pain]]
:**Right lower quadrant
*** Periumbilical
 
***Right lower quadrant
**[[Appendicitis|Acute appendicitis]] symptoms like:
***Loss of [[appetite]]
***[[Nausea and vomiting|Nausea]]
***Typical [[appendicitis]] [[abdominal pain]] which [[Appendicitis diagnostic scoring|starts from preumblical region and move to Mcburny point]].
***[[Nausea and vomiting|Vomiting]]
* '''''If complicated, may present with acute abdomen.'''''
*
* Other nonspecific symptoms of appendix cancer may include the following:<ref>Hardin, M. Acute Appendicitis: Review and Update. ''Am Fam Physician".1999, Nov 1;60(7):2027-2034''</ref>
:* [[Loss of appetite]]
:* [[Loss of appetite]]
:* [[Nausea]]
:* [[Nausea]]
Line 37: Line 47:
:* [[Flatulence]]
:* [[Flatulence]]
:* Bowel irregularity
:* Bowel irregularity
 
*
Common symptoms of [disease] include:
*[Symptom 1]
*[Symptom 2]
*[Symptom 3]


===Less Common Symptoms===
===Less Common Symptoms===
Less common symptoms of [disease name] include
Around 5% of the patients with appendix carcinoid tumors develop [[carcinoid syndrome]] which presents with: <ref name="ss">Signs and symptoms of carcinoid syndrome. National Cancer Institute. http://www.cancer.gov/types/gi-carcinoid-tumors/patient/gi-carcinoid-treatment-pdq</ref>
*[Symptom 1]
*[[Diarrhea]]
*[Symptom 2]
*[[Flushing]]
*[Symptom 3]
*[[Palpitation]]


==References==
==References==
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[[Category: (name of the system)]]
[[Category:Surgery]]
[[Category:Medicine]]
[[Category:Emergency medicine]]
[[Category:Oncology]]
[[Category:Up-To-Date]]

Latest revision as of 17:50, 22 February 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Soroush Seifirad, M.D.[2]

Overview

The majority of patients with appendix cancer are asymptomatic. Patients may complain of vague abdominal pain or discomfort and/or girdle size changes. However, most of them are presenting with acute appendicitis due to obstruction of the appendix by tumor, or present with malignancy complications like pseudomyxoma peritonei; the rest of diagnosed cases are result of serendipitous finding in imaging studies or discovered during laparotomy or laparoscopy because of cancer complications. The patients complains and presentation is influenced by the tumor histology and stage and ranges from a small asymptomatic adenocarcinoma to a metastatic carcinoid tumor with liver metastasis and carcinoid syndrome signs, symptoms and complications.

History and Symptoms

  • The majority of patients with appendix cancer are asymptomatic.

History

Patients with appendix cancer may have a positive history of:[2]

Common Symptoms

Less Common Symptoms

Around 5% of the patients with appendix carcinoid tumors develop carcinoid syndrome which presents with: [4]

References

  1. ↑ Kelly KJ (2015) Management of Appendix Cancer. Clin Colon Rectal Surg 28 (4):247-55. DOI:10.1055/s-0035-1564433 PMID: 26648795
  2. ↑ 2.0 2.1 Chapter 5: Tumours of the Appendix - IARC. https://www.iarc.fr/en/publications/pdfs-online/pat-gen/bb2/bb2-chap5.pdf Accessed on January 15, 2019
  3. ↑ Hardin, M. Acute Appendicitis: Review and Update. Am Fam Physician".1999, Nov 1;60(7):2027-2034
  4. ↑ Signs and symptoms of carcinoid syndrome. National Cancer Institute. http://www.cancer.gov/types/gi-carcinoid-tumors/patient/gi-carcinoid-treatment-pdq

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