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{{CMG}}; {{AE}} {{Soroush}}
{{CMG}}; {{AE}} {{Soroush}}
==Overview==
==Overview==
 
[[Vermiform appendix|Appendix]] [[cancer]] is [[Classification|classifie]]<nowiki/>d according to the [[Histology|histological findings]]. According to [[World Health Organization|WHO]] classification, there are four major groups of appendix cancer including [[Epithelium|epithelial]] [[Tumor|tumors]], non-epithelial tumors, secondary tumors, and [[Hyperplasia|hyperplastic]] (metaplastic) [[polyp]]<nowiki/>s. [[Carcinoid Tumor|Carcinoid]] (well differentiated endocrine neoplasm), and [[adenocarcinoma]] are two major subtypes of [[Epithelial hyperplasia|epithelial tumors]], making the majority of [[Vermiform appendix|appendix]] [[cancer]] cases.
The staging of [malignancy name] is based on the [staging system].
 
 
 
==Classification==
 
'''If the staging system involves specific and characteristic findings and features:'''
 
According to the [staging system + reference], there are [number] stages of [malignancy name] based on the [finding1], [finding2], and [finding3]. Each stage is assigned a [letter/number1] and a [letter/number2] that designate the [feature1] and [feature2].
 
OR
 
The staging of [malignancy name] is based on the [staging system].
 
OR
 
There is no established system for the staging of [malignancy name].
 
[[Category: (name of the system)]]
<br />
 


==Classification==
==Classification==
*Appendix cancer may be classified according to WHO classification into 4 groups:
*[[Vermiform appendix|Appendix]] [[cancer]] may be classified according to [[WHO]] classification into 4 groups:<ref name="WHO">Chapter 5: Tumours of the Appendix - IARC. https://www.iarc.fr/en/publications/pdfs-online/pat-gen/bb2/bb2-chap5.pdf Accessed on January 15, 2019</ref>
:*Epithelial tumors
:*[[Epithelial hyperplasia|Epithelial tumors]]
:*Non-epithelial tumors
:*Non-epithelial tumors
:*Secondary tumors
:*Secondary tumors
:*Hyperplastic (metaplastic) polyp
:*[[Metaplasticity|Hyperplastic (metaplastic) polyps]].
*The table below summarizes the different types of appendix cancer according to the WHO classification.
*The table below summarizes the different types of appendix cancer according to the [[World Health Organization|WHO classification]].
{| style="border: 5px; font-size: 90%; margin: 5px; width: 300px" align="center"
{| style="border: 5px; font-size: 90%; margin: 5px; width: 300px" align="center"
! colspan="2" style="padding: 5px 5px; background: #4479BA; font-weight: bold; text-align:center;" |{{fontcolor|#FFF|'''WHO histological classification<br>Tumors of the appendix <br><SMALL> Adapted from WHO/IARC<ref name="WHO"> Chapter 5: Tumours of the Appendix - IARC. https://www.iarc.fr/en/publications/pdfs-online/pat-gen/bb2/bb2-chap5.pdf Accessed on January 15, 2019</ref> </SMALL>'''}}
! colspan="4" style="padding: 5px 5px; background: #4479BA; font-weight: bold; text-align:center;" |{{fontcolor|#FFF|'''WHO histological classification<br>Tumors of the appendix (Adapted from WHO/IARC)<ref name="WHO"> Chapter 5: Tumours of the Appendix - IARC. https://www.iarc.fr/en/publications/pdfs-online/pat-gen/bb2/bb2-chap5.pdf Accessed on January 15, 2019</ref>'''}}
| valign="top" |
|+
|-
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold; text-align:center;" | Epithelial tumors
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold; text-align:center;" | Epithelial tumors
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold; text-align:center;" | Non-epithelial tumors
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold; text-align:center;" | Secondary tumors
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold; text-align:center;" | Hyperplastic polyp
|-
|-
|  
| style="padding: 5px 5px; background: #F5F5F5; text-align:left;" |
*'''Adenoma'''  
*'''Adenoma'''  
:*Tubular  
:*Tubular  
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*'''Mixed carcinoid-adenocarcinoma'''  
*'''Mixed carcinoid-adenocarcinoma'''  
*'''Others'''
*'''Others'''
|-
| style="padding: 5px 5px; background: #F5F5F5; text-align:left;" |
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold; text-align:center;" | Non-epithelial tumors
|-
|  
*'''Neuroma'''
*'''Neuroma'''
*'''Lipoma'''
*'''Lipoma'''
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*'''Kaposi sarcoma'''
*'''Kaposi sarcoma'''
*'''Others'''
*'''Others'''
*'''Malignant lymphoma'''
*'''Malignant lymphoma'''
|-
| style="padding: 5px 5px; background: #F5F5F5; text-align:left;" |
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold; text-align:center;" | Secondary tumors
| style="padding: 5px 5px; background: #F5F5F5; text-align:left;" |
|-
|  
*'''Metastatic tumors'''
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold; text-align:center;" | Hyperplastic polyp
|}
|}
<references />
 
==References==
{{Reflist|2}}
 
[[Category:Surgery]]
[[Category:Medicine]]
[[Category:Emergency medicine]]
[[Category:Oncology]]
[[Category:Up-To-Date]]

Latest revision as of 18:11, 22 February 2019

Appendix cancer Microchapters

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Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Epidemiology and Demographics

Differentiating Appendix cancer from other Diseases

Risk Factors

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Natural History, Complications and Prognosis

Diagnosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Soroush Seifirad, M.D.[2]

Overview

Appendix cancer is classified according to the histological findings. According to WHO classification, there are four major groups of appendix cancer including epithelial tumors, non-epithelial tumors, secondary tumors, and hyperplastic (metaplastic) polyps. Carcinoid (well differentiated endocrine neoplasm), and adenocarcinoma are two major subtypes of epithelial tumors, making the majority of appendix cancer cases.

Classification

  • The table below summarizes the different types of appendix cancer according to the WHO classification.
WHO histological classification
Tumors of the appendix (Adapted from WHO/IARC)[1]
Epithelial tumors Non-epithelial tumors Secondary tumors Hyperplastic polyp
  • Adenoma
  • Tubular
  • Villous
  • Tubulovillous
  • Serrated
  • Carcinoma
  • Adenocarcinoma
  • Mucinous adenocarcinoma
  • Signet-ring cell carcinoma
  • Small cell carcinoma
  • Undifferentiated carcinoma
  • Carcinoid (well differentiated endocrine neoplasm)
  • EC-cell, serotonin-producing neoplasm
  • L-cell, glucagon-like peptide
  • and PP/PYY producing tumour
  • others
  • Tubular carcinoid
  • Goblet cell carcinoid (mucinous carcinoid)
  • Mixed carcinoid-adenocarcinoma
  • Others
  • Neuroma
  • Lipoma
  • Leiomyoma
  • Gastrointestinal stromal tumor
  • Leiomyosarcoma
  • Kaposi sarcoma
  • Others
  • Malignant lymphoma

References

  1. ↑ 1.0 1.1 Chapter 5: Tumours of the Appendix - IARC. https://www.iarc.fr/en/publications/pdfs-online/pat-gen/bb2/bb2-chap5.pdf Accessed on January 15, 2019
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