Multiple endocrine neoplasia type 2 history and symptoms
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]
Overview
Symptoms of multiple endocrine neoplasia type 2 include headache, hoarseness of voice, palpitations, anxiety, and weight loss.
History and Symptoms
Constitutional Symptoms
- Tall, thin, "marfanoid" body build, in which long bones are disproportionately elongated[1]
- Masses beneath mucosal surfaces in the mouth, lips, and eyes. Numerous yellowish-white, sessile, painless nodules on the lips or tongue, with deeper lesions having normal coloration. There may be enough neuromas in the body of the lips to produce enlargement and a "blubbery lip" appearance. Similar nodules may be seen on the sclera and eyelids.
- Low muscle mass, sometimes with myopathy
- Weight loss
- Delayed puberty
- Sweating
- Hand tremor
- Sleeping difficulty
- Lethargy
Gastrointestinal Symptoms
Respiratory Symptoms
Cardiovascular Symptoms
- Chest pain
- Palpitations
- Anxiety often resembling that of a panic attack
- Diaphoresis
Neurologic Symptoms
Ophthalmology Symptoms
- Dry eyes or lack of tears, which is an especially helpful sign in children
References
- ↑ Multiple endocrine neoplasia type 2. Wikipedia (30.09,2015)https://en.wikipedia.org/wiki/Multiple_endocrine_neoplasia_type_2 accessed on October, 2015