Thrombocytopenia causes: Difference between revisions

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==Medication-induced==
==Medication-induced==
Thrombocytopenia associated with medications can be due to either a reduction in production of platelets or increased destruction.
Thrombocytopenia associated with medications can be due to either a reduction in production of platelets or increased destruction.
=====List of potential etiologies:=====
{{col-begin}}
{{col-break}}


[[Low molecular weight heparin]]s
Sulphonamides
Drugs, hormones and mediators
[[5-Azacytidine]]
[[Abciximab]]
Aclarubicin
[[Actinomycin D]]
[[Aggrastat]]
[[Albendazole]]
[[Alemtuzumab]]
[[Altretamine]]
[[Amiodarone]]
[[Amrinone]]
[[Anagrelide]]
Anazolene
Antithymocyte globulin
[[Ardeparin]]
[[Arsenic]] trioxide
[[Azathioprine]]
[[Bendamustine]]
[[Benoxaprofen]]
[[Bortezomib]]
[[Captopril]]
[[Caspofungin]]
[[Chloramphenicol]]
[[Cilazapril]]
[[Cimetidine]]
[[Cladribine]]
[[Clofarabine]]
[[Dasatinib]]
[[Decitabine]]
[[Desferrioxamine]]
[[Doxorubicin]]
[[Efalizumab]]
{{col-break}}
[[Eflornithine]]
[[Epirubicin]]
[[Eptifibatide]]
[[Ethanol]]
[[Flucytosine]]
[[Fondaparinux]]
[[Ganciclovir]]
[[Gemcitabine]]
[[Gemtuzumab ozogamicin]]
[[Gold salts]]
Guanidinium
Haem arginate
[[Heparin]]
[[Ibritumomab tiuxetan]]
[[Idarubicin]]
[[Imatinib mesylate]]
[[Indomethacin]]
[[Integrilin]]
[[Interferon alpha]]
[[Interleukin 10]]
[[Interleukin 2]]
[[Irinotecan]]
[[Ixabepilone]]
[[Lenalidomide]]
[[Lomustine]]
[[Melphalan]]
[[Mercaptopurine]]
[[Methyldopa]]
Methyldopate
[[Mithramycin]]
[[Nelarabine]]
[[Nilotinib]]
{{col-break}}
[[Nitisinone]]
[[Oxaliplatin]]
Para-amino [[salicylic acid]]
[[Pemetrexed]]
[[Penicillamine]]
[[Pentamidine]]
[[Phenylbutazone]]
[[Pyrimethamine]]
[[Quinidine]]
[[Quinine]]
[[Ranitidine]]
[[ReoPro]]
[[Rifampicin]]
[[Sirolimus]]
[[Sorafenib]]
[[Stiripentol]]
Sulphasalazine
Sunitinib malate
[[Temozolomide]]
[[Ticlopidine]]
[[Tirofiban]]
[[Topotecan]]
[[Trabectedin]]
[[Trimetrexate]]
[[Valganciclovir]]
[[Valproic acid]]
[[Vancomycin]]
[[Vinorelbine]]
[[Vorinostat]]
|}
===Epiphenomenon===
Kasabach-Merritt syndrome
Paraneoplastic syndrome
==References==
==References==
{{Reflist|2}}
{{Reflist|2}}
[[Category:Needs content]]
[[Category:Needs content]]

Revision as of 00:37, 30 August 2012

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Causes

There are two broad mechanisms of thrombocytopenia: reduced platelet production and increased platelet destruction. Thormbocytopenia is seen in a variety of infectious and genetic disorders as well as a side effect of a large list of phramacotherapies.

Decreased production

Vitamin deficiencies

Hematologic disorders

Reduced thrombopoiesis due to reduced thrombopoietin production

Infectious etiologies

Intrauterine acquired conditions

  • Neonatal alloimmune thrombocytopenia
  • Rubella, congenital
  • Syphilis, congenital

Hereditary syndromes

Chromosomal abnormalities
Mendelian inherited conditions
Autosomal dominant conditions
Autosomal recessive conditions
X-linked inherited conditions
  • GATA1-related cytopenia
  • Immunodysregulation polyendocrinopathy and enteropathy, X-linked
  • Wiskott-Aldrich syndrome
  • X-linked hyperimmunoglobulin M syndrome
  • Mitochondrial genome inherited conditions
  • MELAS

Chemical exposure

  • Strontium-89
  • Zinc

Increased destruction

Hematologic Disorders

Cardiovascular causes

Obstetric disorders

Autoimmunde Disorders

Infectious Disorders

  • Dengue fever has been shown to cause shortened platelet survival and immunological platelet destruction
  • HIV [2]

Other disorders

Medication-induced

Thrombocytopenia associated with medications can be due to either a reduction in production of platelets or increased destruction.

List of potential etiologies:

Epiphenomenon

Kasabach-Merritt syndrome Paraneoplastic syndrome

References