PI4KA: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Phosphatidylinositol 4-kinase alpha''' is an [[enzyme]] that in humans is encoded by the ''PI4KA'' [[gene]].<ref name="pmid7961848">{{cite journal |vauthors=Wong K, Cantley LC | title = Cloning and characterization of a human phosphatidylinositol 4-kinase | journal = J Biol Chem | volume = 269 | issue = 46 | pages = 28878–84 |date=Dec 1994 | pmid = 7961848 | pmc =  | doi =  }}</ref><ref name="pmid8662589">{{cite journal |vauthors=Nakagawa T, Goto K, Kondo H | title = Cloning, expression, and localization of 230-kDa phosphatidylinositol 4-kinase | journal = J Biol Chem | volume = 271 | issue = 20 | pages = 12088–94 |date=Aug 1996 | pmid = 8662589 | pmc = | doi =10.1074/jbc.271.20.12088  }}</ref><ref name="entrez"/>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Phosphatidylinositol 4-kinase, catalytic, alpha polypeptide
| HGNCid = 8983
| Symbol = PIK4CA
| AltSymbols =; FLJ16556; PI4K-ALPHA; pi4K230
| OMIM = 600286
| ECnumber = 
| Homologene = 11171
| MGIid = 2448506
| GeneAtlas_image1 = PBB_GE_PIK4CA_213408_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_PIK4CA_207081_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004430 |text = 1-phosphatidylinositol 4-kinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016491 |text = oxidoreductase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0046914 |text = transition metal ion binding}}
| Component = {{GNF_GO|id=GO:0005798 |text = Golgi-associated vesicle}}
| Process = {{GNF_GO|id=GO:0006661 |text = phosphatidylinositol biosynthetic process}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5297
    | Hs_Ensembl = ENSG00000133511
    | Hs_RefseqProtein = XP_001131210
    | Hs_RefseqmRNA = XM_001131210
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 22
    | Hs_GenLoc_start = 19391990
    | Hs_GenLoc_end = 19543070
    | Hs_Uniprot = P42356
    | Mm_EntrezGene = 224020
    | Mm_Ensembl = ENSMUSG00000041720
    | Mm_RefseqmRNA = NM_001001983
    | Mm_RefseqProtein = NP_001001983
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 16
    | Mm_GenLoc_start = 17194132
    | Mm_GenLoc_end = 17319877
    | Mm_Uniprot = 
  }}
}}
'''Phosphatidylinositol 4-kinase, catalytic, alpha polypeptide''', also known as '''PIK4CA''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PIK4CA phosphatidylinositol 4-kinase, catalytic, alpha polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5297| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a [[1-phosphatidylinositol 4-kinase]] which catalyzes the first committed step in the biosynthesis of [[phosphatidylinositol 4,5-bisphosphate]]. The mammalian PI 4-kinases have been classified into two types, II and III, based on their molecular mass, and modulation by detergent and [[adenosine]]. Two transcript variants encoding different isoforms have been described for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: PIK4CA phosphatidylinositol 4-kinase, catalytic, alpha polypeptide| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5297| accessdate = }}</ref>
{{PBB_Summary
 
| section_title =
== Clinical significance ==
| summary_text = This gene encodes a phosphatidylinositol (PI) 4-kinase which catalyzes the first committed step in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. The mammalian PI 4-kinases have been classified into two types, II and III, based on their molecular mass, and modulation by detergent and adenosine. Two transcript variants encoding different isoforms have been described for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: PIK4CA phosphatidylinositol 4-kinase, catalytic, alpha polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5297| accessdate = }}</ref>
 
}}
The alpha isoform of PI4KIII plays a role in replication of [[hepatitis C virus]] (HCV).<ref name="pmid21238945">{{cite journal |vauthors=Reiss S, Rebhan I, Backes P, Romero-Brey I, Erfle H, Matula P, Kaderali L, Poenisch M, Blankenburg H, Hiet MS, Longerich T, Diehl S, Ramirez F, Balla T, Rohr K, Kaul A, Bühler S, Pepperkok R, Lengauer T, Albrecht M, Eils R, Schirmacher P, Lohmann V, Bartenschlager R | title = Recruitment and activation of a lipid kinase by hepatitis C virus NS5A is essential for integrity of the membranous replication compartment | journal = Cell Host Microbe | volume = 9 | issue = 1 | pages = 32–45 |date=January 2011 | pmid = 21238945 | pmc = 3433060 | doi = 10.1016/j.chom.2010.12.002 }}</ref> Furthermore, the PI4KA lipid kinase affects HCV replication by altering phosphorylation of the HCV [[NS5A]] protein.<ref name="pmid23675303">{{cite journal |vauthors=Reiss S, Harak C, Romero-Brey I, Radujkovic D, Klein R, Ruggieri A, Rebhan I, Bartenschlager R, Lohmann V | title = The lipid kinase phosphatidylinositol-4 kinase III alpha regulates the phosphorylation status of hepatitis C virus NS5A | journal = PLoS Pathog. | volume = 9 | issue = 5 | pages = e1003359 |date=May 2013 | pmid = 23675303 | pmc = 3649985 | doi = 10.1371/journal.ppat.1003359 }}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal  |vauthors=Gehrmann T, Heilmeyer LM |title=Phosphatidylinositol 4-kinases. |journal=Eur. J. Biochem. |volume=253 |issue= 2 |pages= 357–70 |year= 1998 |pmid= 9654085 |doi=10.1046/j.1432-1327.1998.2530357.x }}
| citations =
*{{cite journal   |vauthors=Graziani A, Ling LE, Endemann G, etal |title=Purification and characterization of human erythrocyte phosphatidylinositol 4-kinase. Phosphatidylinositol 4-kinase and phosphatidylinositol 3-monophosphate 4-kinase are distinct enzymes |journal=Biochem. J. |volume=284 |issue=  Pt 1|pages= 39–45 |year= 1992 |pmid= 1318025 |doi= | pmc=1132694 }}
*{{cite journal  | author=Gehrmann T, Heilmeyer LM |title=Phosphatidylinositol 4-kinases. |journal=Eur. J. Biochem. |volume=253 |issue= 2 |pages= 357-70 |year= 1998 |pmid= 9654085 |doi=  }}
*{{cite journal   |vauthors=Kauffmann-Zeh A, Thomas GM, Ball A, etal |title=Requirement for phosphatidylinositol transfer protein in epidermal growth factor signaling |journal=Science |volume=268 |issue= 5214 |pages= 1188–90 |year= 1995 |pmid= 7761838 |doi=10.1126/science.7761838 }}
*{{cite journal | author=Graziani A, Ling LE, Endemann G, ''et al.'' |title=Purification and characterization of human erythrocyte phosphatidylinositol 4-kinase. Phosphatidylinositol 4-kinase and phosphatidylinositol 3-monophosphate 4-kinase are distinct enzymes. |journal=Biochem. J. |volume=284 ( Pt 1) |issue=  |pages= 39-45 |year= 1992 |pmid= 1318025 |doi=  }}
*{{cite journal   |vauthors=Prasad KV, Kapeller R, Janssen O, etal |title=Phosphatidylinositol (PI) 3-kinase and PI 4-kinase binding to the CD4-p56lck complex: the p56lck SH3 domain binds to PI 3-kinase but not PI 4-kinase |journal=Mol. Cell. Biol. |volume=13 |issue= 12 |pages= 7708–17 |year= 1994 |pmid= 8246987 |doi= 10.1128/mcb.13.12.7708| pmc=364842 }}
*{{cite journal | author=Kauffmann-Zeh A, Thomas GM, Ball A, ''et al.'' |title=Requirement for phosphatidylinositol transfer protein in epidermal growth factor signaling. |journal=Science |volume=268 |issue= 5214 |pages= 1188-90 |year= 1995 |pmid= 7761838 |doi=  }}
*{{cite journal  |vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
*{{cite journal | author=Wong K, Cantley LC |title=Cloning and characterization of a human phosphatidylinositol 4-kinase. |journal=J. Biol. Chem. |volume=269 |issue= 46 |pages= 28878-84 |year= 1994 |pmid= 7961848 |doi=  }}
*{{cite journal  |vauthors=Berditchevski F, Chang S, Bodorova J, Hemler ME |title=Generation of monoclonal antibodies to integrin-associated proteins. Evidence that alpha3beta1 complexes with EMMPRIN/basigin/OX47/M6 |journal=J. Biol. Chem. |volume=272 |issue= 46 |pages= 29174–80 |year= 1997 |pmid= 9360995 |doi=10.1074/jbc.272.46.29174  }}
*{{cite journal  | author=Prasad KV, Kapeller R, Janssen O, ''et al.'' |title=Phosphatidylinositol (PI) 3-kinase and PI 4-kinase binding to the CD4-p56lck complex: the p56lck SH3 domain binds to PI 3-kinase but not PI 4-kinase. |journal=Mol. Cell. Biol. |volume=13 |issue= 12 |pages= 7708-17 |year= 1994 |pmid= 8246987 |doi=  }}
*{{cite journal   |vauthors=Gehrmann T, Gülkan H, Suer S, etal |title=Functional expression and characterisation of a new human phosphatidylinositol 4-kinase PI4K230 |journal=Biochim. Biophys. Acta |volume=1437 |issue= 3 |pages= 341–56 |year= 1999 |pmid= 10101268 |doi=  10.1016/s1388-1981(99)00029-3}}
*{{cite journal  | author=Nakagawa T, Goto K, Kondo H |title=Cloning, expression, and localization of 230-kDa phosphatidylinositol 4-kinase. |journal=J. Biol. Chem. |volume=271 |issue= 20 |pages= 12088-94 |year= 1996 |pmid= 8662589 |doi= }}
*{{cite journal  |vauthors=Huang C, Handlogten ME, Miller RT |title=Parallel activation of phosphatidylinositol 4-kinase and phospholipase C by the extracellular calcium-sensing receptor |journal=J. Biol. Chem. |volume=277 |issue= 23 |pages= 20293–300 |year= 2002 |pmid= 11907035 |doi= 10.1074/jbc.M200831200 }}
*{{cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Berditchevski F, Chang S, Bodorova J, Hemler ME |title=Generation of monoclonal antibodies to integrin-associated proteins. Evidence that alpha3beta1 complexes with EMMPRIN/basigin/OX47/M6. |journal=J. Biol. Chem. |volume=272 |issue= 46 |pages= 29174-80 |year= 1997 |pmid= 9360995 |doi= }}
*{{cite journal  |vauthors=Subrahmanyam G, Rudd CE, Schneider H |title=Association of T cell antigen CD7 with type II phosphatidylinositol-4 kinase, a key component in pathways of inositol phosphate turnover |journal=Eur. J. Immunol. |volume=33 |issue= 1 |pages= 46–52 |year= 2003 |pmid= 12594831 |doi= 10.1002/immu.200390006 }}
*{{cite journal | author=Gehrmann T, Gülkan H, Suer S, ''et al.'' |title=Functional expression and characterisation of a new human phosphatidylinositol 4-kinase PI4K230. |journal=Biochim. Biophys. Acta |volume=1437 |issue= 3 |pages= 341-56 |year= 1999 |pmid= 10101268 |doi=  }}
*{{cite journal  |vauthors=Carloni V, Mazzocca A, Ravichandran KS |title=Tetraspanin CD81 is linked to ERK/MAPKinase signaling by Shc in liver tumor cells |journal=Oncogene |volume=23 |issue= 8 |pages= 1566–74 |year= 2004 |pmid= 14676841 |doi= 10.1038/sj.onc.1207287 }}
*{{cite journal  | author=Huang C, Handlogten ME, Miller RT |title=Parallel activation of phosphatidylinositol 4-kinase and phospholipase C by the extracellular calcium-sensing receptor. |journal=J. Biol. Chem. |volume=277 |issue= 23 |pages= 20293-300 |year= 2002 |pmid= 11907035 |doi= 10.1074/jbc.M200831200 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal | author=Subrahmanyam G, Rudd CE, Schneider H |title=Association of T cell antigen CD7 with type II phosphatidylinositol-4 kinase, a key component in pathways of inositol phosphate turnover. |journal=Eur. J. Immunol. |volume=33 |issue= 1 |pages= 46-52 |year= 2003 |pmid= 12594831 |doi= 10.1002/immu.200390006 }}
*{{cite journal   |vauthors=Ahn J, Chung KS, Kim DU, etal |title=Systematic identification of hepatocellular proteins interacting with NS5A of the hepatitis C virus |journal=J. Biochem. Mol. Biol. |volume=37 |issue= 6 |pages= 741–8 |year= 2005 |pmid= 15607035 |doi= }}
*{{cite journal | author=Carloni V, Mazzocca A, Ravichandran KS |title=Tetraspanin CD81 is linked to ERK/MAPKinase signaling by Shc in liver tumor cells. |journal=Oncogene |volume=23 |issue= 8 |pages= 1566-74 |year= 2004 |pmid= 14676841 |doi= 10.1038/sj.onc.1207287 }}
*{{cite journal   |vauthors=Weixel KM, Blumental-Perry A, Watkins SC, etal |title=Distinct Golgi populations of phosphatidylinositol 4-phosphate regulated by phosphatidylinositol 4-kinases |journal=J. Biol. Chem. |volume=280 |issue= 11 |pages= 10501–8 |year= 2005 |pmid= 15634669 |doi= 10.1074/jbc.M414304200 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  |vauthors=Israels SJ, McMillan-Ward EM |title=CD63 modulates spreading and tyrosine phosphorylation of platelets on immobilized fibrinogen |journal=Thromb. Haemost. |volume=93 |issue= 2 |pages= 311–8 |year= 2005 |pmid= 15711748 |doi= 10.1160/TH04-08-0503 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Waugh MG, Minogue S, Chotai D, etal |title=Lipid and peptide control of phosphatidylinositol 4-kinase IIalpha activity on Golgi-endosomal Rafts |journal=J. Biol. Chem. |volume=281 |issue= 7 |pages= 3757–63 |year= 2006 |pmid= 16249177 |doi= 10.1074/jbc.M506527200 }}
*{{cite journal  | author=Ahn J, Chung KS, Kim DU, ''et al.'' |title=Systematic identification of hepatocellular proteins interacting with NS5A of the hepatitis C virus. |journal=J. Biochem. Mol. Biol. |volume=37 |issue= 6 |pages= 741-8 |year= 2005 |pmid= 15607035 |doi= }}
*{{cite journal  |vauthors=Israels SJ, McMillan-Ward EM |title=CD63 modulates spreading and tyrosine phosphorylation of platelets on immobilized fibrinogen |journal=Thromb. Haemost. |volume=93 |issue= 2 |pages= 311–8 |year= 2005 |pmid= 15711748 |doi= 10.1160/TH04-08-0503 }}
*{{cite journal | author=Weixel KM, Blumental-Perry A, Watkins SC, ''et al.'' |title=Distinct Golgi populations of phosphatidylinositol 4-phosphate regulated by phosphatidylinositol 4-kinases. |journal=J. Biol. Chem. |volume=280 |issue= 11 |pages= 10501-8 |year= 2005 |pmid= 15634669 |doi= 10.1074/jbc.M414304200 }}
*{{cite journal   |vauthors=Reiss S, etal |title=Recruitment and activation of a lipid kinase by hepatitis C virus NS5A is essential for integrity of the membranous replication compartment |journal=Cell Host Microbe. |volume=9 |issue= 1 |pages= 32–45 |year= 2011 |pmid= 21238945 |doi= 10.1016/j.chom.2010.12.002 |pmc=3433060}}
*{{cite journal  | author=Israels SJ, McMillan-Ward EM |title=CD63 modulates spreading and tyrosine phosphorylation of platelets on immobilized fibrinogen. |journal=Thromb. Haemost. |volume=93 |issue= 2 |pages= 311-8 |year= 2005 |pmid= 15711748 |doi= 10.1267/THRO05020311 }}
*{{cite journal  |vauthors=Reiss S, etal |title=The lipid kinase phosphatidylinositol-4 kinase III alpha regulates the phosphorylation status of hepatitis C virus NS5A |journal=PLoS Pathog. |volume=9 |issue= 5 |pages= e1003359 |year= 2013 |pmid= 23675303 |doi= 10.1371/journal.ppat.1003359 |pmc=3649985}}
*{{cite journal | author=Waugh MG, Minogue S, Chotai D, ''et al.'' |title=Lipid and peptide control of phosphatidylinositol 4-kinase IIalpha activity on Golgi-endosomal Rafts. |journal=J. Biol. Chem. |volume=281 |issue= 7 |pages= 3757-63 |year= 2006 |pmid= 16249177 |doi= 10.1074/jbc.M506527200 }}
}}
{{refend}}
{{refend}}


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[[Category:EC 2.7.1]]

Revision as of 18:05, 7 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Phosphatidylinositol 4-kinase alpha is an enzyme that in humans is encoded by the PI4KA gene.[1][2][3]

Function

This gene encodes a 1-phosphatidylinositol 4-kinase which catalyzes the first committed step in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. The mammalian PI 4-kinases have been classified into two types, II and III, based on their molecular mass, and modulation by detergent and adenosine. Two transcript variants encoding different isoforms have been described for this gene.[3]

Clinical significance

The alpha isoform of PI4KIII plays a role in replication of hepatitis C virus (HCV).[4] Furthermore, the PI4KA lipid kinase affects HCV replication by altering phosphorylation of the HCV NS5A protein.[5]

References

  1. ↑ Wong K, Cantley LC (Dec 1994). "Cloning and characterization of a human phosphatidylinositol 4-kinase". J Biol Chem. 269 (46): 28878–84. PMID 7961848.
  2. ↑ Nakagawa T, Goto K, Kondo H (Aug 1996). "Cloning, expression, and localization of 230-kDa phosphatidylinositol 4-kinase". J Biol Chem. 271 (20): 12088–94. doi:10.1074/jbc.271.20.12088. PMID 8662589.
  3. ↑ 3.0 3.1 "Entrez Gene: PIK4CA phosphatidylinositol 4-kinase, catalytic, alpha polypeptide".
  4. ↑ Reiss S, Rebhan I, Backes P, Romero-Brey I, Erfle H, Matula P, Kaderali L, Poenisch M, Blankenburg H, Hiet MS, Longerich T, Diehl S, Ramirez F, Balla T, Rohr K, Kaul A, Bühler S, Pepperkok R, Lengauer T, Albrecht M, Eils R, Schirmacher P, Lohmann V, Bartenschlager R (January 2011). "Recruitment and activation of a lipid kinase by hepatitis C virus NS5A is essential for integrity of the membranous replication compartment". Cell Host Microbe. 9 (1): 32–45. doi:10.1016/j.chom.2010.12.002. PMC 3433060. PMID 21238945.
  5. ↑ Reiss S, Harak C, Romero-Brey I, Radujkovic D, Klein R, Ruggieri A, Rebhan I, Bartenschlager R, Lohmann V (May 2013). "The lipid kinase phosphatidylinositol-4 kinase III alpha regulates the phosphorylation status of hepatitis C virus NS5A". PLoS Pathog. 9 (5): e1003359. doi:10.1371/journal.ppat.1003359. PMC 3649985. PMID 23675303.

Further reading

Retrieved from "https://www.wikidoc.org/index.php?title=PI4KA&oldid=1419965"