Protein-histidine pros-kinase

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In enzymology, a protein-histidine pros-kinase (EC is an enzyme that catalyzes the chemical reaction

ATP + protein L-histidine ADP + protein Npi-phospho-L-histidine

Thus, the two substrates of this enzyme are ATP and protein L-histidine, whereas its two products are ADP and protein Npi-phospho-L-histidine.

This enzyme belongs to the family of transferases, specifically those transferring a phosphate group to the sidechain of histidine residues in proteins (protein-histidine kinases). The systematic name of this enzyme class is ATP:protein-L-histidine Npi-phosphotransferase. Other names in common use include ATP:protein-L-histidine N-pros-phosphotransferase, histidine kinase (ambiguous), histidine protein kinase (ambiguous), protein histidine kinase (ambiguous), protein kinase (histidine) (ambiguous), and HK2.


  • IUBMB entry for
  • BRENDA references for (Recommended.)
  • PubMed references for
  • PubMed Central references for
  • Google Scholar references for
  • Fujitaki JM, Fung G, Oh EY, Smith RA (1981). "Characterization of chemical and enzymatic acid-labile phosphorylation of histone H4 using phosphorus-31 nuclear magnetic resonance". Biochemistry. 20: 3658&ndash, 64. PMID 7196259.
  • Huebner VD, Matthews HR (1985). "Phosphorylation of histidine in proteins by a nuclear extract of Physarum polycephalum plasmodia". J. Biol. Chem. 260: 16106&ndash, 13. PMID 4066704.

External links

The CAS registry number for this enzyme class is 99283-67-7.

Gene Ontology (GO) codes