Class I PI 3-kinases
Class I PI 3-kinases are a subgroup of the enzyme family, phosphoinositide 3-kinase that share a common protein domain structure, substrate specificity and method of activation. Class I PI 3-kinases are further divided into two subclasses, class IA PI 3-kinases and class IB PI 3-kinases.
Class IA PI 3-kinases
Class IA PI 3-kinases are activated by receptor tyrosine kinases (RTKs).
There are three catalytic subunits which are classified as class IA PI 3-kinases:
There are currently five regulatory subunits which are known to associate with class IA PI 3-kinases catalytic subunits:
Class IB PI 3-kinases
Class IB PI 3-kinases are activated by G-protein-coupled receptors (GPCRs)
The only known class IB PI 3-kinase catalytic subunit is p110γ
There are two known regulatory subunits for p110γ:
- Stein RC ( 2001) Prospects for phosphoinositide 3-kinase inhibition as a cancer treatment Endocr Relat Cancer 8:237-248 
- Foster FM, Traer CJ, Abraham SM, and Fry MJ (2003) The phosphoinositide (PI) 3-kinase family J Cell Sci 116:3037-3040.
- Vanhaesebroeck B, Waterfield MD.(1999) Signaling by distinct classes of phosphoinositide 3-kinases. Exp Cell Res. 253(1):239-54.
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