Syncope natural history, complications and prognosis

	Syncope Microchapters
Home
Patient Information
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Syncope from other Diseases
Epidemiology and Demographics
Risk Factors
Natural History, Complications and Prognosis
Diagnosis
History and Symptoms
Physical Examination
Laboratory Findings
Electrocardiogram
X ray
CT
MRI
Echocardiography
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Primary Prevention
Secondary Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies
Case #1
Syncope natural history, complications and prognosis On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Syncope natural history, complications and prognosis All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Syncope natural history, complications and prognosis
CDC on Syncope natural history, complications and prognosis
Syncope natural history, complications and prognosis in the news
Blogs on Syncope natural history, complications and prognosis
Directions to Hospitals Treating Syncope
Risk calculators and risk factors for Syncope natural history, complications and prognosis

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Sara Zand, M.D.[2] Sahar Memar Montazerin, M.D.[3]

Overview

Patients with syncope are at risk of the development of complications, such as trauma from frequent falls and Sudden cardiac death. The prognosis of syncope depends on underlying causes. Syncope caused by cardiovascular diseases may be life-threatening and is an important cause of sudden cardiac death. Prognosis of vasovagal syncope is favorable.

Natural history, Complications and Prognosis

Natural History

If the underlying cause of syncope is left untreated and syncope occurs frequently, patients with syncope may suffer from trauma of the head and neck and sudden cardiac death due to fatal cardiac arrhythmia.

Clinical characteristics of the uncommon causes of syncope include the following:^[1]^[2]^[3]^[4]^[5]^[6]^[7]^[8]^[9]^[10]^[11]^[12]^[13]^[14]^[15]^[16]

Uncommon conditions associated with syncope	Clinical aspect	Cause of syncope
Cardiac tamponade	Hypotension, tachycardia, cardiogenic shock	Tachycardia, hypotension, abrupt bradycardia
Constrictive pericarditis	Heart failure symptoms, exertional dyspnea, orthopnea, edema	Cough syncope
Left ventricular non compaction	Trabeculation or recess in left ventricle	Tachyarrhythmia
Takotsubo cardiomyopathy	Apical ballooning , basal hyperkinesia , following stressful event, chest pain and ECG change mimicking ischemia	Uncommon cause of syncope, multifactorial
Pulmonary embolus	Cardiac arrest and pulseless electrical activity following hypoxia, tachycardia, hypotension and shock	Bradycardia, hypotension
Pulmonary arterial hypertension	Exertional syncope, especially in younger patients	Peripheral vasodilation following exercise, low cardiac output state
Amyloidosis	Amyloid deposition in heat, kidney, peripheral and autonomic nervous system	AV block, arrhythmia, low cardiac output due to restrictive cardiomyopathy
Hemochromatosis	Dilated cardiomyopathy due to iron deposition	Myocardial involvement, sick sinus syndrome, AV block
Myocarditis	Chest pain, arrhythmia, left ventricular systolic dysfunction, hemodynamic collapse	Ventricular tachycardia, AV block, transient hemodynamic collapse
Lyme disease	Myocarditis accompanied by erythma migrant, neurologic involvement	AV block, vasovagal syncope
disease	Cardiomyopathy caused by trypanosomiasis	Ventricular tachycardia, AV block
Friedreich ataxia	Hypertrophic Cardiomyopathy (HCM), gait ataxia, bladder dysfunction	Tachycardia, bradycardia, SCD is common
Cardiac tumors	Triad of valve obstruction , emboli, systemic signs and symptoms	Obstruction of blood flow
Prosthetic valve thrombosis	Asymptomatic or symptomatic heart failure	Embolic event, valve obstruction
Anomalous coronary artery	Common cause of exertional syncope and SCD specially in young athletes	Bezold jarisch reflex,hypotension, VT, AV block
Subclavian steal syndrome	Significant stenosis in subclavian artery leading flow reversal in vertebral artery and vertebrobasilar ischemia and syncope	Syncope following upper extremities activity
Aortic dissection	Neurologic symptoms, heart failure symptoms, myocardial infarction	Increased risk of in-hospital death, tamponade, neurologic deficit in patients with syncope
Coarctation of the aorta (COA)	Heart failure symptoms, dissection of aorta	Associated with bicuspid aortic valve stenosis
Rheumatoid arthritis	Systemic inflammatory disorder	Complete heart block
Carcinoid syndrome, Pheochromocytoma, Mastocytosis, Vasoactive intestinal peptide tumor	Vasodilation, flushing, pruritus, gastrointestinal symptoms	Transient hypotension
Beta thalassemia major	Dilated cardiomyopathy , severe anemia, multiple organ failure	Arrhythmia
Migraine	Association between headache and syncope	Vasovagal syncope, orthostase intolerance
Seizure-induced bradycardia, hypotension	Temporal lobe epilepsy	Postictal bradyarrhythmia due to temporal lobe or limbic system

Complications

Patients with syncope are at risk of the development of the following complications:^[17]

Frequent falls resulting in injuries to head and neck
Development of cardiovascular disorders
Sudden cardiac death
Death

Prognosis

The prognosis of syncope depends on underlying causes.^[18]^[19]

Syncope caused by cardiovascular diseases may be life-threatening and is an important cause of sudden cardiac death.
Prognosis of vasovagal syncope is favorable.

References

↑ . doi:10.2169/internalmedicine.52.8818. Check |doi= value (help). Missing or empty |title= (help)
↑ Vasquez, Andres F.; Seger, John J. (2009). "An Uncommon Case of Heart Failure". Southern Medical Journal. 102 (11): 1183–1185. doi:10.1097/SMJ.0b013e3181b63b1c. ISSN 0038-4348.
↑ Rovetta R, Bonadei I, Vizzardi E, D'Aloia A, Metra M (August 2014). "Syncope as presentation of recurrent Tako-Tsubo cardiomyopathy". Minerva Cardioangiol. 62 (4): 366–8. PMID 25012104.
↑ Prandoni P, Lensing AW, Prins MH, Ciammaichella M, Perlati M, Mumoli N, Bucherini E, Visonà A, Bova C, Imberti D, Campostrini S, Barbar S (October 2016). "Prevalence of Pulmonary Embolism among Patients Hospitalized for Syncope". N Engl J Med. 375 (16): 1524–1531. doi:10.1056/NEJMoa1602172. PMID 27797317.
↑ Strobel JS, Fuisz AR, Epstein AE, Plumb VJ (October 1999). "Syncope and inducible ventricular fibrillation in a woman with hemochromatosis". J Interv Card Electrophysiol. 3 (3): 225–9. doi:10.1023/a:1009891406964. PMID 10490478.
↑ Akashi R, Kizaki Y, Kawano H, Takahara Y, Nakao K, Yonemitsu N, Kusumoto S, Maemura K (2012). "Seizures and syncope due to complete atrioventricular block in a patient with acute myocarditis with a normal left ventricular systolic function". Intern Med. 51 (21): 3035–40. doi:10.2169/internalmedicine.51.8410. PMID 23124146.
↑ Ciesielski CA, Markowitz LE, Horsley R, Hightower AW, Russell H, Broome CV (1989). "Lyme disease surveillance in the United States, 1983-1986". Rev Infect Dis. 11 Suppl 6: S1435–41. PMID 2682955.
↑ . doi:10.1016/j.amjcard.2008.12.013. Check |doi= value (help). Missing or empty |title= (help)
↑ Perryman RA, Bayne E, Miller RH (April 1991). "Bull-worker syncope: congenital subclavian steal syndrome following isometric exercise". Pediatr Cardiol. 12 (2): 105–6. doi:10.1007/BF02238413. PMID 1866327.
↑ Squarzoni G, Bariani L, Fogli B, Ughi M, Manfredini R, Fersini C (1991). "[Arterial hypertension and syncope in an adult patient with coarctation of the aorta]". Riv Eur Sci Med Farmacol (in Italian). 13 (1–2): 33–5. PMID 1796194.
↑ Kremastinos DT, Farmakis D, Aessopos A, Hahalis G, Hamodraka E, Tsiapras D, Keren A (May 2010). "Beta-thalassemia cardiomyopathy: history, present considerations, and future perspectives". Circ Heart Fail. 3 (3): 451–8. doi:10.1161/CIRCHEARTFAILURE.109.913863. PMID 20484195.
↑ Reynen K (December 1995). "Cardiac myxomas". N Engl J Med. 333 (24): 1610–7. doi:10.1056/NEJM199512143332407. PMID 7477198.
↑ Monté CP, de Krom MC, Weber WE, de Zwaan C, van Kranen-Mastenbroek VH (March 2007). "The ictal bradycardia syndrome". Acta Neurol Belg. 107 (1): 22–5. PMID 17569230.
↑ Ahern M, Lever JV, Cosh J (August 1983). "Complete heart block in rheumatoid arthritis". Ann Rheum Dis. 42 (4): 389–97. doi:10.1136/ard.42.4.389. PMC 1001249. PMID 6882034.
↑ Silber H, Khan SS, Matloff JM, Chaux A, DeRobertis M, Gray R (January 1993). "The St. Jude valve. Thrombolysis as the first line of therapy for cardiac valve thrombosis". Circulation. 87 (1): 30–7. doi:10.1161/01.cir.87.1.30. PMID 8419020.
↑ Velazquez-Ceceña JL, Lubell DL, Nagajothi N, Al-Masri H, Siddiqui M, Khosla S (2009). "Syncope from dynamic left ventricular outflow tract obstruction simulating hypertrophic cardiomyopathy in a patient with primary AL-type amyloid heart disease". Tex Heart Inst J. 36 (1): 50–4. PMC 2676515. PMID 19436787.
↑ Auer, J. (2008). "Syncope and trauma. Are syncope-related traumatic injuries the key to find the specific cause of the symptom?". European Heart Journal. 29 (5): 576–578. doi:10.1093/eurheartj/ehm637. ISSN 0195-668X.
↑ Soteriades, Elpidoforos S.; Evans, Jane C.; Larson, Martin G.; Chen, Ming Hui; Chen, Leway; Benjamin, Emelia J.; Levy, Daniel (2002). "Incidence and Prognosis of Syncope". New England Journal of Medicine. 347 (12): 878–885. doi:10.1056/NEJMoa012407. ISSN 0028-4793.
↑ Saklani, Pradyot; Krahn, Andrew; Klein, George (2013). "Syncope". Circulation. 127 (12): 1330–1339. doi:10.1161/CIRCULATIONAHA.112.138396. ISSN 0009-7322.

[1] . doi:10.2169/internalmedicine.52.8818. Check |doi= value (help). Missing or empty |title= (help)

[VasquezSeger2009-2] Vasquez, Andres F.; Seger, John J. (2009). "An Uncommon Case of Heart Failure". Southern Medical Journal. 102 (11): 1183–1185. doi:10.1097/SMJ.0b013e3181b63b1c. ISSN 0038-4348.

[pmid25012104-3] Rovetta R, Bonadei I, Vizzardi E, D'Aloia A, Metra M (August 2014). "Syncope as presentation of recurrent Tako-Tsubo cardiomyopathy". Minerva Cardioangiol. 62 (4): 366–8. PMID 25012104.

[pmid27797317-4] Prandoni P, Lensing AW, Prins MH, Ciammaichella M, Perlati M, Mumoli N, Bucherini E, Visonà A, Bova C, Imberti D, Campostrini S, Barbar S (October 2016). "Prevalence of Pulmonary Embolism among Patients Hospitalized for Syncope". N Engl J Med. 375 (16): 1524–1531. doi:10.1056/NEJMoa1602172. PMID 27797317.

[pmid10490478-5] Strobel JS, Fuisz AR, Epstein AE, Plumb VJ (October 1999). "Syncope and inducible ventricular fibrillation in a woman with hemochromatosis". J Interv Card Electrophysiol. 3 (3): 225–9. doi:10.1023/a:1009891406964. PMID 10490478.

[pmid23124146-6] Akashi R, Kizaki Y, Kawano H, Takahara Y, Nakao K, Yonemitsu N, Kusumoto S, Maemura K (2012). "Seizures and syncope due to complete atrioventricular block in a patient with acute myocarditis with a normal left ventricular systolic function". Intern Med. 51 (21): 3035–40. doi:10.2169/internalmedicine.51.8410. PMID 23124146.

[pmid2682955-7] Ciesielski CA, Markowitz LE, Horsley R, Hightower AW, Russell H, Broome CV (1989). "Lyme disease surveillance in the United States, 1983-1986". Rev Infect Dis. 11 Suppl 6: S1435–41. PMID 2682955.

[8] . doi:10.1016/j.amjcard.2008.12.013. Check |doi= value (help). Missing or empty |title= (help)

[pmid1866327-9] Perryman RA, Bayne E, Miller RH (April 1991). "Bull-worker syncope: congenital subclavian steal syndrome following isometric exercise". Pediatr Cardiol. 12 (2): 105–6. doi:10.1007/BF02238413. PMID 1866327.

[pmid1796194-10] Squarzoni G, Bariani L, Fogli B, Ughi M, Manfredini R, Fersini C (1991). "[Arterial hypertension and syncope in an adult patient with coarctation of the aorta]". Riv Eur Sci Med Farmacol (in Italian). 13 (1–2): 33–5. PMID 1796194.

[pmid20484195-11] Kremastinos DT, Farmakis D, Aessopos A, Hahalis G, Hamodraka E, Tsiapras D, Keren A (May 2010). "Beta-thalassemia cardiomyopathy: history, present considerations, and future perspectives". Circ Heart Fail. 3 (3): 451–8. doi:10.1161/CIRCHEARTFAILURE.109.913863. PMID 20484195.

[pmid7477198-12] Reynen K (December 1995). "Cardiac myxomas". N Engl J Med. 333 (24): 1610–7. doi:10.1056/NEJM199512143332407. PMID 7477198.

[pmid17569230-13] Monté CP, de Krom MC, Weber WE, de Zwaan C, van Kranen-Mastenbroek VH (March 2007). "The ictal bradycardia syndrome". Acta Neurol Belg. 107 (1): 22–5. PMID 17569230.

[pmid6882034-14] Ahern M, Lever JV, Cosh J (August 1983). "Complete heart block in rheumatoid arthritis". Ann Rheum Dis. 42 (4): 389–97. doi:10.1136/ard.42.4.389. PMC 1001249. PMID 6882034.

[pmid8419020-15] Silber H, Khan SS, Matloff JM, Chaux A, DeRobertis M, Gray R (January 1993). "The St. Jude valve. Thrombolysis as the first line of therapy for cardiac valve thrombosis". Circulation. 87 (1): 30–7. doi:10.1161/01.cir.87.1.30. PMID 8419020.

[pmid19436787-16] Velazquez-Ceceña JL, Lubell DL, Nagajothi N, Al-Masri H, Siddiqui M, Khosla S (2009). "Syncope from dynamic left ventricular outflow tract obstruction simulating hypertrophic cardiomyopathy in a patient with primary AL-type amyloid heart disease". Tex Heart Inst J. 36 (1): 50–4. PMC 2676515. PMID 19436787.

[Auer2008-17] Auer, J. (2008). "Syncope and trauma. Are syncope-related traumatic injuries the key to find the specific cause of the symptom?". European Heart Journal. 29 (5): 576–578. doi:10.1093/eurheartj/ehm637. ISSN 0195-668X.

[SoteriadesEvans2002-18] Soteriades, Elpidoforos S.; Evans, Jane C.; Larson, Martin G.; Chen, Ming Hui; Chen, Leway; Benjamin, Emelia J.; Levy, Daniel (2002). "Incidence and Prognosis of Syncope". New England Journal of Medicine. 347 (12): 878–885. doi:10.1056/NEJMoa012407. ISSN 0028-4793.

[SaklaniKrahn2013-19] Saklani, Pradyot; Krahn, Andrew; Klein, George (2013). "Syncope". Circulation. 127 (12): 1330–1339. doi:10.1161/CIRCULATIONAHA.112.138396. ISSN 0009-7322.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]

[17]

[18]

[19]