Pineal parenchymal tumor with intermediate differentiation

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Synonyms and Keywords: Pineal parenchymal tumors with intermediate differentiation; Pineal parenchymal tumour with intermediate differentiation; Pineal parenchymal tumours with intermediate differentiation; PPTID; Pineal parenchymal tumor; Pineal gland tumor; Brain tumor

Overview

  • Pineal parenchymal tumor with intermediate differentiation is a pineal parenchymal tumor, which falls between pineocytoma (well differentiated, WHO grade I) and pineoblastoma (poorly differentiated, WHO grade IV). It is considered as a WHO grade II / III tumor according to the WHO classification of tumors of the central nervous system.[1][2]
  • On microscopic histopathological analysis, pineal parenchymal tumor with intermediate differentiation is characterized by:[3]
  • Pineal parenchymal tumor with intermediate differentiation is demonstrated by positivity to tumor markers such as:[4]

Epidemiology

  • Pineal parenchymal tumor with intermediate differentiation constitutes about 20% of the pineal gland tumors.[5]
  • Pineal parenchymal tumor with intermediate differentiation constitutes less than 0.3% of all primary central nervous system tumors.[6]
  • Pineal parenchymal tumor with intermediate differentiation is a rare disease that tends to affect all the age groups, most commonly in the middle age adult population.[1][5]
  • Pineal parenchymal tumor with intermediate differentiation affects men and women equally.[1]

Prognosis

  • Common complications of pineal parenchymal tumor with intermediate differentiation include local invasion and CSF metastasis.[1]
  • The mainstay of therapy for pineal parenchymal tumor with intermediate differentiation is combined radiation and chemotherapy.[7] Surgical resection may be helpful in some cases.

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References

  1. 1.0 1.1 1.2 1.3 Pineal parenchymal tumor with intermediate differentiation. Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/pineal-parenchymal-tumour-with-intermediate-differentiation. Accessed on November 23, 2015
  2. Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A; et al. (2007). "The 2007 WHO classification of tumours of the central nervous system". Acta Neuropathol. 114 (2): 97–109. doi:10.1007/s00401-007-0243-4. PMC 1929165. PMID 17618441.
  3. Microscopic features of pineal parenchymal tumor with intermediate differentiation. Libre Pathology 2015. http://librepathology.org/wiki/index.php/Pineal_gland#Pineal_parenchymal_tumor_of_intermediate_differentiation. Accessed on November 23, 2015
  4. Pusztaszeri M, Pica A, Janzer R (2006). "Pineal parenchymal tumors of intermediate differentiation in adults: case report and literature review". Neuropathology. 26 (2): 153–7. PMID 16708548.
  5. 5.0 5.1 General features of pineal parenchymal tumor with intermediate differentiation. Libre Pathology 2015. http://librepathology.org/wiki/index.php/Pineal_gland#Pineal_parenchymal_tumor_of_intermediate_differentiation. Accessed on November 23, 2015
  6. Watanabe T, Mizowaki T, Arakawa Y, Iizuka Y, Ogura K, Sakanaka K; et al. (2014). "Pineal parenchymal tumor of intermediate differentiation: Treatment outcomes of five cases". Mol Clin Oncol. 2 (2): 197–202. doi:10.3892/mco.2013.231. PMC 3917789. PMID 24649332.
  7. Stoiber EM, Schaible B, Herfarth K, Schulz-Ertner D, Huber PE, Debus J; et al. (2010). "Long term outcome of adolescent and adult patients with pineal parenchymal tumors treated with fractionated radiotherapy between 1982 and 2003--a single institution's experience". Radiat Oncol. 5: 122. doi:10.1186/1748-717X-5-122. PMC 3019157. PMID 21184689.
  8. 8.0 8.1 8.2 8.3 Microscopic images of pineal parenchymal tumor with intermediate differentiation. Libre pathology 2015. http://librepathology.org/wiki/index.php/Pineal_gland#Pineal_parenchymal_tumor_of_intermediate_differentiation. Accessed on November 23, 2015

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