Levosulpiride

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Levosulpiride
Levosulpiride.png
Names
IUPAC name
N-[[(2S)-1-Ethylpyrrolidin-2-yl]methyl]-2-methoxy-5-sulfamoylbenzamide
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
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KEGG
Properties
C15H23N3O4S
Molar mass 341.43 g·mol−1

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

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Levosulpiride is a substituted benzamide antipsychotic, reported to be a selective antagonist of dopamine D2 receptor activity on both central and peripheral levels. It is an atypical neuroleptic and a prokinetic agent. Levosulpiride is also claimed to have mood elevating properties. Levosulpiride is used in the treatment of psychoses, particularly negative symptoms of schizophrenia, anxiety disorders, dysthymia, vertigo, dyspepsia, irritable bowel syndrome and premature ejaculation.

Chemically, it is the (S)-enantiomer of sulpiride.

Side effect

Side effects include amenorrhoea, gynaecomastia, galactorrhoea, changes in libido, and neuroleptic malignant syndrome.[1] It also effects GI motility may be antagonized by anticholinergic agents, narcotics and analgesics.[citation needed]

Mechanism of action

In contrast to most other neuroleptics which block both dopamine D1 and D2 receptors, sulpiride is more selective and acts primarily as a dopamine D2 antagonist. Sulpiride appears to lack effects on norepinephrine, acetylcholine, serotonin, histamine, or gamma-aminobutyric acid (GABA) receptors. [2]

Pharmacodynamics

Sulpiride is a substituted benzamide derivative and a selective dopamine D2 antagonist with antipsychotic and antidepressant activity. Other benzamide derivatives include metoclopramide, tiapride, and sultopride.[3]

References


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