Leg swelling

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Leg swelling
Leg Swelling in Elephantiasis

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List of terms related to Leg swelling

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shankar Kumar, M.B.B.S. [2]

Synonyms and keywords: Lower extremity swelling


Leg selling is a non-specific finding on physical examination. Leg swelling often occurs secondary to drugs, obstruction to venous or lymphatic outflow, and leakage from vessels.

Differential Diagnosis of Causes of Leg swelling

Complete Differential Diagnosis of the Causes of Leg swelling

(By organ system)

Cardiovascular Arteriovenous Fistula , Cardiomyopathy, Chronic Venous insufficiency , Constrictive pericarditis, Cor pulmonale, Ischemia , Kawasaki disease, Kawasaki syndrome, left ventricular failure, May-Thurner syndrome, Mitral Stenosis , Phlebitis, Phlebothrombosis , Phlegmasia cerulea dolens, Postischemic , Post-thrombotic syndrome, Systemic vasculitis , Thrombophlebitis , Thrombosis in the vena cava , Uncompensated hypertension , Varicosis , Venous insufficiency
Chemical / poisoning No underlying causes
Dermatologic Angioneurotic edema , erysipelas, Erythema nodosum, Erythromelalgia, hereditary lymphedema, Hypertrophic osteopathy, idiopathic edema, ishemic leg edemas, Lymphedema, Sebaceous cyst, Secondary lymphatic blockage , Thrombophlebitis, Phlebothrombosis , Varicosis , Elephantiasis due to filaria
Drug Side Effect Abacavir, Acebutolol (patient information), Acitretin (patient information), Acyclovir (patient information), Adalimumab Injection (patient information), Adderall, Albuterol (patient information), Alfuzosin (patient information), Aliskiren, Aliskiren (patient information), Aliskiren (patient information), Alitretinoin (patient information), Amantadine (patient information), Amiodarone, Amlodipine (patient information), Amlodipine and Benazepril (patient information), Anagrelide (patient information), Anastrozole (patient information), Aripiprazole (patient information), Asparaginase (patient information), Atenolol (patient information), Atorvastatin (patient information), Azithromycin, Benazepril (patient information), Bepridil (patient information), Bicalutamide (patient information), Bisoprolol (patient information), Bortezomib (patient information), Candesartan (patient information), Capecitabine (patient information), Carboplatin (patient information), Carmustine (patient information), Carvedilol (patient information), Caspofungin, Chondroitin sulfate, Cidofovir Injection (patient information), Cilostazol (patient information), Ciprofloxacin, Clarithromycin, Clopidogrel (patient information), Cyanocobalamin Injection (patient information), Cyclosporine (patient information), Cytomegalovirus Immune Globulin Intravenous Injection (patient information), Danazol (patient information), Deferasirox (patient information), Dexamethasone Oral (patient information), Diclofenac and Misoprostol (patient information), Didanosine (patient information), Diethylpropion (patient information), Diflunisal, Digoxin Oral (patient information), Diltiazem (patient information), Diphenoxylate and Atropine (patient information), Disopyramide (patient information), Doxazosin (patient information), Enalapril (patient information), Enalapril and Felodipine (patient information), Enalapril and Hydrochlorothiazide (patient information), Eprosartan (patient information), Esomeprazole (patient information), Eszopiclone (patient information), Etanercept Injection (patient information), Etidronate (patient information), Etodolac (patient information), Exenatide Injection (patient information), Ezetimibe (patient information), Famotidine (patient information), Felodipine (patient information), Fenoprofen (patient information), Fexofenadine (patient information), Fexofenadine and Pseudoephedrine (patient information), Fluconazole (patient information), Fluorouracil (patient information), Flutamide (patient information), Fluticasone and Salmeterol Oral Inhalation (patient information), Fluticasone Oral Inhalation (patient information), Fluvastatin (patient information), Formoterol (patient information), Fosinopril (patient information), Gabapentin, Ganciclovir (patient information), Gatifloxacin (patient information), Gefitinib (patient information), Gemcitabine Hydrochloride (patient information), Glatiramer Injection (patient information), Histrelin Injection (patient information), Hydrocortisone Injection (patient information), Hydrocortisone Oral (patient information), Hydrocortisone, Neomycin, and Polymyxin (patient information), Hydroxyurea (patient information), Imatinib (patient information), Imiglucerase Injection (patient information), Indomethacin (patient information), Infliximab Injection (patient information), Insulin Glulisine (rDNA origin) Injection (patient information), Interferon Beta-1b Injection (patient information), Interferon Gamma-1b Injection (patient information), Ipratropium and Albuterol Inhalation (patient information), Ipratropium Oral Inhalation (patient information), Irbesartan (patient information), Isradipine (patient information), Labetalol Oral (patient information), Lamotrigine (patient information), Lansoprazole/clarithromycin/amoxicillin (patient information), Letrozole (patient information), Leuprolide (patient information), Levocarnitine Injection (patient information), Levodopa and Carbidopa (patient information), Levofloxacin Injection (patient information), Levofloxacin Oral (patient information), Lisinopril (patient information), Lisinopril and Hydrochlorothiazide (patient information), Lithium (patient information), Lomefloxacin (patient information), Loratadine (patient information), Losartan (patient information), Losartan and Hydrochlorothiazide (patient information), Lovastatin (patient information), Meclofenamate (patient information), Medroxyprogesterone (patient information), Mefenamic acid, Mesalamine (patient information), Metoclopramide Hydrochloride Injection (patient information), Metoprolol, Mitomycin (patient information), Modafinil (patient information), Moexipril (patient information), Mycophenolate (patient information), Nabumetone (patient information), Nadolol (patient information), Natalizumab injection (patient information), Nevirapine (patient information), Nicardipine (patient information), Nifedipine (patient information), Nisoldipine (patient information), Norethindrone (patient information), Norfloxacin (patient information), Olanzapine (patient information), Olmesartan (patient information), Omeprazole (patient information), Ondansetron (patient information), Oxandrolone, Oxaprozin, Oxcarbazepine (patient information), Oxiconazole (patient information), Oxybutynin (patient information), Oxycodone and aspirin (patient information), Palifermin (patient information), Pamidronate injection (patient information), Pancrelipase, Pegaspargase (patient information), Peginterferon alfa-2a (patient information), Peginterferon alfa-2b (patient information), Perindopril (patient information), Phenazopyridine (patient information), Phenelzine (patient information), Phentermine (patient information), Phenytoin oral (patient information), Pimecrolimus topical (patient information), Pindolol (patient information), Piroxicam (patient information), Posaconazole (patient information), Pramipexole (patient information), Pramoxine (patient information), Pravastatin (patient information), Prednisolone, Prednisone, Pregabalin (patient information), Propranolol Oral (patient information), Propylthiouracil (patient information), Quinapril (patient information), Raloxifene, Ramipril, Ribavirin (patient information), Risedronate (patient information), Ritonavir (patient information), Ropinirole (patient information), Rosuvastatin (patient information), Salsalate (patient information), Sargramostim injection (patient information), Sibutramine (patient information), Simvastatin (patient information), Sirolimus (patient information), Sodium bicarbonate (patient information), Solifenacin (patient information), Sotalol (patient information), Sulfinpyrazone (patient information), Sulindac (patient information), Sunitinib (patient information), Tacrolimus topical (patient information), Tamoxifen (patient information), Tamsulosin (patient information), Telithromycin (patient information), Telmisartan (patient information), Temozolomide (patient information), Terazosin (patient information), Testosterone Buccal (patient information), Testosterone Topical (patient information), Thioguanine (patient information), Tiludronate (patient information), Timolol Oral (patient information), Tinidazole (patient information), Tolmetin, Trandolapril (patient information), Tranylcypromine (patient information), Trazodone (patient information), Triamcinolone Oral (patient information), Triamcinolone Topical (patient information), Valganciclovir (patient information), Valsartan (patient information), Vardenafil (patient information), Verapamil, Verapamil and Trandolapril (patient information), Voriconazole (patient information), Vorinostat (patient information), Zanamivir Inhalation (patient information),Zoledronic Acid Injection (patient information)|-
Ear Nose Throat No underlying causes
Endocrine Diabetes mellitus, Diabetic nephropathy, Graves' Disease, hyperaldosteronism, hyperthyroidism, hypothyroidism, Myxedema
Environmental heat, Allergy, Bee sting
Gastroenterologic Ascites, exudative enteropathy, Hernia, Hypoalbuminemia, Liver disease with synthesis disorder or portal vein stasis , Malabsorption , Protein-Losing Enteropathy
Genetic Turner's Syndrome
Hematologic Deep Vein Thrombosis, Pernicious anemia
Iatrogenic No underlying causes
Infectious Disease Adenitis, Bubonic plague, Cellulitis, African Trypanosomiasis, Bubo, Dracunculiasis, elephantiasis, Elephantiasis due to filaria , filariasis, Handigodu Syndrome, erysipelas
Musculoskeletal / Ortho Baker's cyst , Bursitis, Compartment syndrome, Compartment syndrome, Ewings sarcoma, Fuchs' dystrophy, Ganglion cyst, Giant cell tumor of bone, Iliotibial band syndrome, Infantile cortical hyperostosis, Kohler disease, Meniscal cyst, Myorrhexis , Osteoblastoma, Osteochondroma, Osteochondrosis, Osteosarcoma, Palindromic rheumatism, Pigmented villonodular synovitis, Psoriatic arthritis, Sudeck's atrophy , Synovial osteochondromatosis, Synovial sarcoma, Water on knee
Neurologic No underlying causes
Nutritional / Metabolic Beriberi, Beriberi Heart Disease, Malnutrition , Obesity hypoventilation syndrome
Obstetric/Gynecologic Pre-eclampsia, edema proteinuria hypertension (EPH) gestosis, Pregnancy, Premenstrual
Oncologic No underlying causes
Opthalmologic No underlying causes
Overdose / Toxicity Cladribine (patient information), Atenolol (patient information), Bisoprolol (patient information), Cyclosporine (patient information), Ganciclovir (patient information), Metoprolol, Nadolol (patient information), Nifedipine (patient information), Oxycodone and aspirin (patient information), Palifermin (patient information), Propylthiouracil (patient information)
Psychiatric No underlying causes
Pulmonary No underlying causes
Renal / Electrolyte Congenital nephrotic syndrome, glomerulonephritis, Lupus nephritis, Nephrotic Syndrome , Renal failure
Rheum / Immune / Allergy Allergic Reaction, Allergy, Bee sting, Omenn syndrome, Reiter's Disease:Patient Information, Gout, Diabetic nephropathy, Hypoalbuminemia
Sexual No underlying causes
Trauma Local trauma , Posttraumatic
Urologic No underlying causes
Dental No underlying causes
Miscellaneous After radiation therapy , Benign tumor, cancer, Chemotherapy, hyperhydration, Insect bite and stings, Neoplastic , Orthostatic , Palmar plantar erythrodysesthesia, Postoperative , Tumor compression , Tumor in the area of the hypogastrium , Hernia, Angioneurotic edema , idiopathic edema, ishemic leg edemas, Secondary lymphatic blockage , Hypoalbuminemia

Alphabetical order

(In alphabetical order) [1] [2]


  1. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:77 ISBN 1591032016
  2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:68 ISBN 140510368X

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