High chylomicron causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Twinkle Singh, M.B.B.S. [2]


Hyperchylomicronemia occurs more commonly as a result of decreased lipoprotein lipase enzyme activity. The causes of hyperchylomicronemia could either be genetic as in type I and type V hyperlipoproteinemia or secondary to conditions such as alcoholism, chronic renal failure, hypothyroidism, and diabetes mellitus. Secondary causes are more frequent than primary genetic etiologies.


Life Threatening Causes

Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated.

Hyperchylomicronemia does not have life-threatening causes.

Common Causes

Causes by Organ System

Cardiovascular No underlying causes
Chemical/Poisoning No underlying causes
Dental No underlying causes
Dermatologic No underlying causes
Drug Side Effect Heparin, oral contraceptives, thiazide diuretics
Ear Nose Throat No underlying causes
Endocrine Diabetes mellitus, hypothyroidism
Environmental No underlying causes
Gastroenterologic No underlying causes
Genetic Glycogen storage disease type I, lipoprotein lipase deficiency, type 1C hyperlipoproteinemia, mixed hyperlipoproteinemia
Hematologic No underlying causes
Iatrogenic No underlying causes
Infectious Disease No underlying causes
Musculoskeletal/Orthopedic No underlying causes
Neurologic No underlying causes
Nutritional/Metabolic Familial hypertriglyceridemia, glycogen storage disease type I, lipoprotein lipase deficiency
Obstetric/Gynecologic Pregnancy
Oncologic No underlying causes
Ophthalmologic No underlying causes
Overdose/Toxicity Alcohol
Psychiatric No underlying causes
Pulmonary No underlying causes
Renal/Electrolyte Chronic renal failure
Rheumatology/Immunology/Allergy Autoimmune hyperchylomicronemia [1]
Sexual No underlying causes
Trauma No underlying causes
Urologic No underlying causes
Miscellaneous No underlying causes

Causes by Alphabetical Order


  1. 1.0 1.1 Yoshimura, T.; Ito, M.; Sakoda, Y.; Kobori, S.; Okamura, H. (1998). "Rare case of autoimmune hyperchylomicronemia during pregnancy". Eur J Obstet Gynecol Reprod Biol. 76 (1): 49–51. PMID 9481547. Unknown parameter |month= ignored (help)

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