Estrogen related receptor

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estrogen-related receptor alpha
Identifiers
SymbolESRRA
Alt. symbolsESRL1
Entrez2101
HUGO3471
OMIM601998
RefSeqNM_004451
UniProtP11474
Other data
LocusChr. 11 q12
estrogen-related receptor beta
Identifiers
SymbolESRRB
Alt. symbolsESRL2
Entrez2103
HUGO3473
OMIM602167
RefSeqNM_004452
UniProtO95718
Other data
LocusChr. 14 q24.3
estrogen-related receptor gamma
Identifiers
SymbolESRRG
Entrez2104
HUGO3474
OMIM602969
RefSeqNM_206595
UniProtP62508
Other data
LocusChr. 1 q41

There are three known estrogen related receptors:

The ERRs are members of the orphan nuclear receptor family.

ERR's bind to estrogen response elements on DNA and modulate transcription but do not bind to endogenous estrogens.

In addition, ERR's seem to have their own response elements termed ERRE's. ERR's have been shown to play a role in energy homeostasis and cancer.[1]

References

  1. Ariazi E, Jordan V (2006). "Estrogen-related receptors as emerging targets in cancer and metabolic disorders". Curr Top Med Chem. 6 (3): 203–15. PMID 16515477.

External links


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