Celiac disease risk factors

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Furqan M M. M.B.B.S[2]Seyedmahdi Pahlavani, M.D. [3]


Common risk factors in the development of celiac disease include a positive family history, HLA genes, other autoimmune diseases, infections, and certain drugs.

Risk Factors

Common risk factors in the development of celiac disease may be environmental, genetic, infections and certain drugs.[1]

Common Risk Factors

Less Common Risk Factors

  • Less common risk factors in the development of celiac disease include:[16]
    • Non-recommended infant feeding practices:


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  10. 10.0 10.1 "www.omicsonline.org".
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  12. Stene LC, Honeyman MC, Hoffenberg EJ, Haas JE, Sokol RJ, Emery L, Taki I, Norris JM, Erlich HA, Eisenbarth GS, Rewers M (2006). "Rotavirus infection frequency and risk of celiac disease autoimmunity in early childhood: a longitudinal study". Am. J. Gastroenterol. 101 (10): 2333–40. doi:10.1111/j.1572-0241.2006.00741.x. PMID 17032199.
  13. Zanoni G, Navone R, Lunardi C, Tridente G, Bason C, Sivori S, Beri R, Dolcino M, Valletta E, Corrocher R, Puccetti A (2006). "In celiac disease, a subset of autoantibodies against transglutaminase binds toll-like receptor 4 and induces activation of monocytes". PLoS Med. 3 (9): e358. doi:10.1371/journal.pmed.0030358. PMC 1569884. PMID 16984219.
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