Celiac disease causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Furqan M M. M.B.B.S[2]

Overview

The common causes of celiac disease are autoantibodies to gluten and certain genetic factors.

Causes

The common causes of celiac disease are autoantibodies to gluten and certain genetic factors.

Common Causes

Celiac disease is usually caused by:

• Autoantibodies against gluten which is found in:
  • Wheat
  • Barley
  • Rye

Genetic Causes

• Celiac disease is linked to the HLA genes usually HLA DQ2 and HLA DQ8.
  • CELIAC1 (6p21)
• Non-HLA genes are also thought to be related to celiac disease:
  • CELIAC2 (5q31-33)
  • CELIAC3 (2q33)
  • CELIAC4 (19p13·1)