Pheochromocytoma natural history, complications and prognosis: Difference between revisions
| Line 6: | Line 6: | ||
==Overview== | ==Overview== | ||
The prognosis of pheochromocytoma is generally good but metastatic pheochromocytoma has a 5-year survival rate of approximately 45%.<ref name="cancergov">National Cancer Institute. Physician Data Query Database 2015. http://www.cancer.gov/types/pheochromocytoma/hp/pheochromocytoma-treatment-pdq#link/_25_toc</ref> Massive release of [[catecholamines]] can causes damage to myocytes. | |||
==Natural History, Complication and Prognosis== | ==Natural History, Complication and Prognosis== | ||
===Natural History=== | ===Natural History=== | ||
Pheochromocytoma is adrenaline secreting tumor, usually develop in fifth decade of life. Symptoms start with tachycardia, hypertension, headache and sweating. If left untreated it causes hyperglycemia, | Pheochromocytoma is adrenaline secreting tumor, usually develop in fifth decade of life. Symptoms start with tachycardia, hypertension, headache and sweating. If left untreated it causes hyperglycemia, hypertension emergency that causes heart failure, cerebrovascular strokes. If malignant, It cam metastasize to [[lymph nodes]], [[bones]], [[lungs]], and [[liver]]. | ||
===Complication=== | ===Complication=== | ||
* The massive release of [[catecholamines]] in pheochromocytoma can cause damage to | * The massive release of [[catecholamines]] in pheochromocytoma can cause damage to myocytes.<ref name="Goldman_327">{{Harvnb|Goldman|2011|pp=327}}</ref> This damage may be due to either a compromise of the [[coronary microcirculation]] or the direct toxic effects of catecholamines on myocytes.<ref name="Goldman_327" /> | ||
Other complications may include: | Other complications may include: | ||
*[[Hyperglycemia]] due to opposing insulin effect by high doses of adrenaline secreted by tumor. | *[[Hyperglycemia]] due to opposing insulin effect by high doses of adrenaline secreted by tumor. | ||
| Line 25: | Line 23: | ||
* Approximately 10% recur after being resected. | * Approximately 10% recur after being resected. | ||
* Patients with metastatic pheochromocytoma five-year survival rates are approximately 50%. | * Patients with metastatic pheochromocytoma five-year survival rates are approximately 50% . Tumor burden, location of metastases, and rate of progression are the main factors affecting prognosis. Metastases in brain, liver have a worse prognosis than other metastases. | ||
* Survival rate may depend on the primary tumor site and sites of metastases. [[lungs]], and [[liver]] metastases have worse prognosis than bone. | |||
==References== | ==References== | ||
Revision as of 17:14, 7 July 2017
|
Pheochromocytoma Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Pheochromocytoma natural history, complications and prognosis On the Web |
|
American Roentgen Ray Society Images of Pheochromocytoma natural history, complications and prognosis |
|
FDA on Pheochromocytoma natural history, complications and prognosis |
|
CDC on Pheochromocytoma natural history, complications and prognosis |
|
Pheochromocytoma natural history, complications and prognosis in the news |
|
Blogs on Pheochromocytoma natural history, complications and prognosis |
|
Risk calculators and risk factors for Pheochromocytoma natural history, complications and prognosis |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmad Al Maradni, M.D. [2]
Please help WikiDoc by adding content here. It's easy! Click here to learn about editing.
Overview
The prognosis of pheochromocytoma is generally good but metastatic pheochromocytoma has a 5-year survival rate of approximately 45%.[1] Massive release of catecholamines can causes damage to myocytes.
Natural History, Complication and Prognosis
Natural History
Pheochromocytoma is adrenaline secreting tumor, usually develop in fifth decade of life. Symptoms start with tachycardia, hypertension, headache and sweating. If left untreated it causes hyperglycemia, hypertension emergency that causes heart failure, cerebrovascular strokes. If malignant, It cam metastasize to lymph nodes, bones, lungs, and liver.
Complication
- The massive release of catecholamines in pheochromocytoma can cause damage to myocytes.[2] This damage may be due to either a compromise of the coronary microcirculation or the direct toxic effects of catecholamines on myocytes.[2]
Other complications may include:
- Hyperglycemia due to opposing insulin effect by high doses of adrenaline secreted by tumor.
- Malignant hypertension that may cause cerebrovascular accidents such as intracranial hemorrhage, coronary syndrome, aortic dissection and heart failure.
- Metastasis to lymph nodes, bones, lungs, and liver.
Prognosis
- Pheochromocytoma prognosis is good if treated.
- Approximately 10% recur after being resected.
- Patients with metastatic pheochromocytoma five-year survival rates are approximately 50% . Tumor burden, location of metastases, and rate of progression are the main factors affecting prognosis. Metastases in brain, liver have a worse prognosis than other metastases.
- Survival rate may depend on the primary tumor site and sites of metastases. lungs, and liver metastases have worse prognosis than bone.
References
- ↑ National Cancer Institute. Physician Data Query Database 2015. http://www.cancer.gov/types/pheochromocytoma/hp/pheochromocytoma-treatment-pdq#link/_25_toc
- ↑ 2.0 2.1 Goldman 2011, pp. 327