Pheochromocytoma history and symptoms: Difference between revisions

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(Created page with "{{Pheochromocytoma}} {{CMG}} ==Overview== A '''pheochromocytoma''' ('''phaeochromocytoma''' outside of the US) is a neuroendocrine tumor of the [[Adrenal medulla|medulla...")
 
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Tumors may grow very large, but most are smaller than 10 cm.
Tumors may grow very large, but most are smaller than 10 cm.
==Tumor Location==
In adults, 90% tumors are located unilaterally and are solitary, and 10% are located outside the adrenal gland. In children 50% are adrenal, while 25% are bilateral and 25% are extraadrenal. The common extradrenal locations are the abdomen, thorax and urinary bladder.


==References==
==References==

Revision as of 12:28, 21 January 2012

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

A pheochromocytoma (phaeochromocytoma outside of the US) is a neuroendocrine tumor of the medulla of the adrenal glands (originating in the chromaffin cells) or extra-adrenal chromaffin tissue which failed to involute after birth,[1] which secretes excessive amounts of catecholamines, usually epinephrine and norepinephrine. Extra-adrenal paragangliomas (often described as extra-adrenal pheochromocytomas) are closely related, though less common, tumors that originate in the ganglia of the sympathetic nervous system and are named based upon the primary anatomical site of origin.

History and symptoms

The signs and symptoms of a pheochromocytoma are those of sympathetic nervous system hyperactivity, including:

A pheochromocytoma can also cause resistant arterial hypertension. A pheochromocytoma can be fatal if it causes malignant hypertension, or severely high blood pressure. This hypertension is not well controlled with standard blood pressure medications.

Not all patients experience all of the signs and symptoms listed. The most common presentation is headache, excessive sweating, and increased heart rate, with the attack subsiding in less than one hour.

Tumors may grow very large, but most are smaller than 10 cm.

Tumor Location

In adults, 90% tumors are located unilaterally and are solitary, and 10% are located outside the adrenal gland. In children 50% are adrenal, while 25% are bilateral and 25% are extraadrenal. The common extradrenal locations are the abdomen, thorax and urinary bladder.

References

  1. Boulpaep, Emile L.; Boron, Walter F. (2003). Medical physiology: a cellular and molecular approach. Philadelphia: Saunders. p. 1065. ISBN 0-7216-3256-4.

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