Leg pain

Leg pain Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aditya Govindavarjhulla, M.B.B.S. [2], Raviteja Guddeti, M.B.B.S. [3]

Overview

Leg pain is a common non-specific symptom that often has a musculoskeletal, metabolic or drug side effect basis.

Complete Differential Diagnosis of the causes of Leg pain

Common Causes

• Arterial thromboembolism
• Arthritis
• Autoimmune vascular disorders such as vasculitis
• Baker's cyst
• Cholesterol embolism
• Chronic venous insufficiency
• Connective tissue disease
• Coxsackie B
• Deep Vein Thrombosis (DVT)
• Drugs, toxins
• Hypocalcemia
• Hypokalemia
• Hyponatremia
• Leptospirosis
• Ligament damage
• Lumbar canal stenosis or spinal stenosis
• Muscle or tendon strain
• Night cramps
• Obliterating endarteritis
• Peripheral neuropathy
• Peripheral vascular disease
• Plexopathy
• Primary varicosis
• Radiculopathy
• Restless Leg Syndrome
• Venous thromboembolism (VTE)

Causes by Organ system

Cardiovascular	Aortoiliac occlusive disease,Cholesterol Emboli Syndrome,Deep Vein Thrombosis,Peripheral Arterial Disease,Thrombophlebitis,Varicose veins
Chemical / poisoning	No underlying causes
Dermatologic	Behect's disease
Drug Side Effect	Abatacept Injection,Acebutolol,Acitretin,Aldesleukin,Alendronate,Allopurinol,Amikacin Sulfate Injection,Anagrelide,Anastrozole,Aripiprazole,Atazanavir,Atenolol,Atorvastatin,Bevacizumab Injection,Bortezomib,Buspirone,Capecitabine,Celecoxib,Celiac disease,Clofarabine Injection,Clonazepam,Clopidogrel,Cortisol,Darbepoetin Alfa,Docetaxel,Epoetin Alfa Injection,Ethacrynic Acid,Etidronate,Ezetimibe,Fenofibrate,Filgrastim,Fluvastatin,Gabapentin,Galantamine,Glatiramer Injection,Ibandronate,Iloprost,Imatinib,Infliximab Injection,Interferon Alfa-2a and Alfa-2b Injection,Interferon Alfacon-1 Injection,Interferon beta-1a Intramuscular Injection,Interferon Beta-1b Injection,Interferon Gamma-1b Injection,Lamivudine,Latanoprost,Leflunomide,Letrozole,Leuprolide,Lovastatin,Methimazole,Methylergonovine,Methylprednisolone,Mifepristone,Natalizumab injection ,Ofloxacin ,Paclitaxel,Peginterferon alfa-2a,Prednisone,Pyrazinamide,Quinupristin dalfopristin,Ribavirin,Rofecoxib,Rosiglitazone,Rosuvastatin,Sunitinib ,Tadalafil ,Tamsulosin ,Telbivudine ,Temozolomide ,Terbutaline,Teriparatide,Tiotropium,Torsemide,Valganciclovir,Valsartan,Vancomycin,Vinblastine,Vincristine,Zalcitabine,Ziprasidone,Zolmitriptan,Zolpidem,
Ear Nose Throat	No underlying causes
Endocrine	Hyperparathyroidism,Primary hyperparathyroidism
Environmental	No underlying causes
Gastroenterologic	Ulcerative colitis
Genetic	Fairbanks disease,Familial Mediterranean fever,Mitochondrial trifunctional protein deficiency,Osteogenesis imperfecta,Hereditary multiple exostoses,Recessive multiple epiphyseal dysplasia,Farber disease
Hematologic	Erdheim-Chester disease,Leukemia,Lymphangiomatosis,Multiple myeloma,Phlebitis,Phlegmasia cerulea dolens,Thrombocytosis,Acute lymphoblastic leukemia,Acute myeloid leukemia,Acute promyelocytic leukemia,Cholesterol Embolism
Iatrogenic	No underlying causes
Infectious Disease	Bacterial : Cellulitis,Q Fever,Lassa Fever,Lemierre's Syndrome,Leptospirosis Viral : Parvovirus,Poliomyelitis,Rocky Mountain spotted fever,Acquired Immune Deficiency Syndrome,Coxsackie B,
Musculoskeletal / Ortho	Athlete's foot,Baker's cyst,Bone tumor,Buerger's disease,Chondroblastoma,Chondromalacia patellae,Chondrosarcoma,Gout,Hereditary multiple exostoses,Ledderhose's disease,Legg-Calve-Perthes syndrome,Morton's toe,Myofascial Pain Syndrome,Myositis ossificans,Osteochondrosis,Paget's disease of bone,Pes anserinus (leg),Pigmented villonodular synovitis,Prepatellar bursitis,Recessive multiple epiphyseal dysplasia,Retropatellar Pain Syndrome,Sciatica,Synovial osteochondromatosis,Tenosynovitis,Erythromelagia,Ewing's sarcoma,Giant cell tumor of bone,Osteoporosis,Still's disease,Fairbanks disease,Osteogenesis imperfecta
Neurologic	Amyotrophic Lateral Sclerosis,Anterior spinal artery syndrome,Erythromelagia,Meralgia paraesthetica,Peripheral Neuropathy,Restless Leg Syndrome
Nutritional / Metabolic	Acute Intermittent Porphyria,Farber disease,Glycogen storage disease type V, Hypercalcemia,Mucopolysaccharidosis,Osteomalacia
Obstetric/Gynecologic	No underlying causes
Oncologic	Acute lymphoblastic leukemia,Acute myeloid leukemia,Acute promyelocytic leukemia,Ewing's sarcoma,Giant cell tumor of bone,Osteochondroma,Osteoma,Osteosarcoma,Leukemia,Lymphangiomatosis,Chondroblastoma,Chondrosarcoma
Opthalmologic	Behect's disease
Overdose / Toxicity	No underlying causes
Psychiatric	Pain disorder
Pulmonary	No underlying causes
Renal / Electrolyte	Hypercalcemia,Hypocalcemia,Hypokalemia,Hyponatremia
Rheum / Immune / Allergy	Rheumatology : Ankylosing Spondylitis,Behcet's disease,Caplan's Syndrome,Fibromyalgia,Osteoarthritis,Osteoporosis,Polymyalgia Rheumatica,Rheumatoid arthritis,Still's disease, Gout Immunology : Systemic lupus erythematosus,Ulcerative colitis,Vasculitis,Graft-versus-host disease,Familial Mediterranean fever
Sexual	No underlying causes
Trauma	No underlying causes
Urologic	No underlying causes
Dental	No underlying causes
Miscellaneous	Phantom pain

Causes in Alphabetical order

1. Abatacept Injection
2. Acebutolol
3. Acitretin
4. Acquired Immune Deficiency Syndrome
5. Acute Intermittent Porphyria
6. Acute lymphoblastic leukemia
7. Acute myeloid leukemia
8. Acute promyelocytic leukemia
9. Aldesleukin
10. Alendronate
11. Allopurinol
12. Amikacin Sulfate Injection
13. Amyotrophic Lateral Sclerosis
14. Anagrelide
15. Anastrozole
16. Ankylosing Spondylitis
17. Anterior spinal artery syndrome
18. Aortoiliac occlusive disease
19. Aripiprazole
20. Atazanavir
21. Atenolol
22. Athlete's foot
23. Atorvastatin
24. Baker's cyst
25. Behcet's disease
26. Bevacizumab Injection
27. Bone tumor
28. Bortezomib
29. Buerger's disease
30. Buspirone
31. Capecitabine
32. Caplan's Syndrome
33. Celecoxib
34. Celiac disease
35. Cellulitis
36. Cholesterol Emboli Syndrome
37. Chondroblastoma
38. Chondromalacia patellae
39. Chondrosarcoma
40. Clofarabine Injection
41. Clonazepam
42. Clopidogrel
43. Cortisol
44. Coxsackie B
45. Darbepoetin Alfa Injection
46. Deep Vein Thrombosis
47. Docetaxel
48. Epoetin Alfa Injection
49. Erdheim-Chester disease
50. Erythromelagia
51. Ethacrynic Acid
52. Etidronate
53. Ewing's sarcoma
54. Ezetimibe
55. Fairbanks disease
56. Familial Mediterranean fever
57. Farber disease
58. Fenofibrate
59. Fibromyalgia
60. Filgrastim
61. Fluvastatin
62. Gabapentin
63. Galantamine
64. Giant cell tumor of bone
65. Glatiramer Injection
66. Glycogen storage disease type V
67. Gout
68. Graft-versus-host disease
69. Hereditary multiple exostoses
70. Hypercalcemia
71. Hypercalcemia
72. Hyperparathyroidism
73. Hypocalcemia
74. Hypokalemia
75. Hyponatremia
76. Ibandronate
77. Iloprost
78. Imatinib
79. Infliximab Injection
80. Interferon Alfa-2a and Alfa-2b Injection
81. Interferon Alfacon-1 Injection
82. Interferon beta-1a Intramuscular Injection
83. Interferon Beta-1b Injection
84. Interferon Gamma-1b Injection
85. Lamivudine
86. Lassa Fever
87. Latanoprost
88. Ledderhose's disease
89. Leflunomide
90. Legg-Calve-Perthes syndrome
91. Lemierre's Syndrome
92. Letrozole
93. Leukemia
94. Leuprolide
95. Lovastatin
96. Lymphangiomatosis
97. Meralgia paraesthetica
98. Methimazole
99. Methylergonovine Oral
100. Methylprednisolone Oral
101. Mifepristone
102. Mitochondrial trifunctional protein deficiency
103. Morton's toe
104. Mucopolysaccharidosis
105. Multiple myeloma
106. Myofascial Pain Syndrome
107. Myositis ossificans
108. Natalizumab injection
109. Ofloxacin
110. Osteoarthritis
111. Osteochondroma
112. Osteochondrosis
113. Osteogenesis imperfecta
114. Osteoma
115. Osteomalacia
116. Osteoporosis
117. Osteosarcoma
118. Paclitaxel
119. Paget's disease of bone
120. Pain disorder
121. Parvovirus
122. Peginterferon alfa-2a
123. Peripheral Arterial Disease
124. Peripheral Neuropathy
125. Pes anserinus (leg)
126. Phantom pain
127. Phlebitis
128. Phlegmasia cerulea dolens
129. Pigmented villonodular synovitis
130. Poliomyelitis
131. Polymyalgia Rheumatica
132. Prednisone
133. Prepatellar bursitis
134. Primary hyperparathyroidism
135. Pyrazinamide
136. Q Fever
137. Quinupristin and dalfopristin injection
138. Recessive multiple epiphyseal dysplasia
139. Retropatellar Pain Syndrome
140. Rheumatoid arthritis
141. Ribavirin
142. Rocky Mountain spotted fever
143. Rofecoxib
144. Rosiglitazone
145. Rosuvastatin
146. Sciatica
147. Still's disease
148. Sunitinib
149. Synovial osteochondromatosis
150. Systemic lupus erythematosus
151. Tadalafil
152. Tamsulosin
153. Telbivudine
154. Temozolomide
155. Tenosynovitis
156. Terbutaline
157. Teriparatide (rDNA origin) Injection
158. Thrombocytosis
159. Thrombophlebitis
160. Tiotropium Oral Inhalation
161. Torsemide Injection
162. Ulcerative colitis
163. Valganciclovir
164. Valsartan
165. Vancomycin
166. Varicose veins
167. Vasculitis
168. Vinblastine
169. Vincristine
170. Zalcitabine
171. Ziprasidone
172. Zolmitriptan Nasal
173. Zolpidem

References

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