KCNJ8: Difference between revisions

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{{Infobox_gene}}
{{GNF_Protein_box
'''Potassium inwardly-rectifying channel, subfamily J, member 8''', also known as '''KCNJ8''', is a human [[gene]] encoding the '''K<sub>ir</sub>6.1''' protein.<ref name="entrez">{{cite web | title = Entrez Gene: KCNJ8 potassium inwardly-rectifying channel, subfamily J, member 8| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3764| accessdate = }}</ref> A mutation in KCNJ8 has been associated with cardiac arrest in the early repolarization syndrome.
| image = 
| image_source = 
| PDB =
| Name = Potassium inwardly-rectifying channel, subfamily J, member 8
| HGNCid = 6269
| Symbol = KCNJ8
| AltSymbols =; KIR6.1; uKATP-1
| OMIM = 600935
| ECnumber = 
| Homologene = 3654
| MGIid = 1100508
| GeneAtlas_image1 = PBB_GE_KCNJ8_205304_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_KCNJ8_205303_at_tn.png
| Function = {{GNF_GO|id=GO:0005244 |text = voltage-gated ion channel activity}} {{GNF_GO|id=GO:0015272 |text = ATP-activated inward rectifier potassium channel activity}} {{GNF_GO|id=GO:0030955 |text = potassium ion binding}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0008076 |text = voltage-gated potassium channel complex}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0030016 |text = myofibril}}
| Process = {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006813 |text = potassium ion transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3764
    | Hs_Ensembl = ENSG00000121361
    | Hs_RefseqProtein = NP_004973
    | Hs_RefseqmRNA = NM_004982
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 12
    | Hs_GenLoc_start = 21809156
    | Hs_GenLoc_end = 21819014
    | Hs_Uniprot = Q15842
    | Mm_EntrezGene = 16523
    | Mm_Ensembl = ENSMUSG00000030247
    | Mm_RefseqmRNA = NM_008428
    | Mm_RefseqProtein = NP_032454
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 6
    | Mm_GenLoc_start = 142522146
    | Mm_GenLoc_end = 142528581
    | Mm_Uniprot = Q3U118
  }}
}}
'''Potassium inwardly-rectifying channel, subfamily J, member 8''', also known as '''KCNJ8''' or '''K<sub>IR</sub>6.1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: KCNJ8 potassium inwardly-rectifying channel, subfamily J, member 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3764| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins.<ref name="entrez">{{cite web | title = Entrez Gene: KCNJ8 potassium inwardly-rectifying channel, subfamily J, member 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3764| accessdate = }}</ref>
| summary_text = Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. K<sub>ir</sub>6.1 is an integral membrane protein and inward-rectifier type potassium channel. K<sub>ir</sub>6.1, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins.<ref name="entrez" />
}}
}}


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==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
Line 65: Line 20:
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Kubo Y, Adelman JP, Clapham DE, ''et al.'' |title=International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels. |journal=Pharmacol. Rev. |volume=57 |issue= 4 |pages= 509-26 |year= 2006 |pmid= 16382105 |doi= 10.1124/pr.57.4.11 }}
*{{cite journal  | author=Kubo Y |title=International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels |journal=Pharmacol. Rev. |volume=57 |issue= 4 |pages= 509–526 |year= 2006 |pmid= 16382105 |doi= 10.1124/pr.57.4.11  |name-list-format=vanc| author2=Adelman JP  | author3=Clapham DE  | display-authors=3  | last4=Jan  | first4=LY  | last5=Karschin  | first5=A  | last6=Kurachi  | first6=Y  | last7=Lazdunski  | first7=M  | last8=Nichols | first8=CG  | last9=Seino  | first9=S }}
*{{cite journal | author=Inagaki N, Tsuura Y, Namba N, ''et al.'' |title=Cloning and functional characterization of a novel ATP-sensitive potassium channel ubiquitously expressed in rat tissues, including pancreatic islets, pituitary, skeletal muscle, and heart. |journal=J. Biol. Chem. |volume=270 |issue= 11 |pages= 5691-4 |year= 1995 |pmid= 7890693 |doi=  }}
*{{cite journal  | author=Inagaki N |title=Cloning and functional characterization of a novel ATP-sensitive potassium channel ubiquitously expressed in rat tissues, including pancreatic islets, pituitary, skeletal muscle, and heart |journal=J. Biol. Chem. |volume=270 |issue= 11 |pages= 5691–5694 |year= 1995 |pmid= 7890693 |doi=10.1074/jbc.270.11.5691  |name-list-format=vanc| author2=Tsuura Y | author3=Namba N  | display-authors=3  | last4=Masuda  | first4=K | last5=Gonoi  | first5=T  | last6=Horie  | first6=M  | last7=Seino  | first7=Y  | last8=Mizuta  | first8=M  | last9=Seino  | first9=S  }}
*{{cite journal  | author=Inagaki N, Inazawa J, Seino S |title=cDNA sequence, gene structure, and chromosomal localization of the human ATP-sensitive potassium channel, uKATP-1, gene (KCNJ8). |journal=Genomics |volume=30 |issue= 1 |pages= 102-4 |year= 1996 |pmid= 8595887 |doi= 10.1006/geno.1995.0018 }}
*{{cite journal  |vauthors=Inagaki N, Inazawa J, Seino S |title=cDNA sequence, gene structure, and chromosomal localization of the human ATP-sensitive potassium channel, uKATP-1, gene (KCNJ8) |journal=Genomics |volume=30 |issue= 1 |pages= 102–104 |year= 1996 |pmid= 8595887 |doi= 10.1006/geno.1995.0018 }}
*{{cite journal | author=Suzuki M, Kotake K, Fujikura K, ''et al.'' |title=Kir6.1: a possible subunit of ATP-sensitive K+ channels in mitochondria. |journal=Biochem. Biophys. Res. Commun. |volume=241 |issue= 3 |pages= 693-7 |year= 1998 |pmid= 9434770 |doi= 10.1006/bbrc.1997.7891 }}
*{{cite journal  | author=Suzuki M |title=Kir6.1: a possible subunit of ATP-sensitive K+ channels in mitochondria |journal=Biochem. Biophys. Res. Commun. |volume=241 |issue= 3 |pages= 693–697 |year= 1998 |pmid= 9434770 |doi= 10.1006/bbrc.1997.7891 |name-list-format=vanc| author2=Kotake K  | author3=Fujikura K  | display-authors=3  | last4=Inagaki  | first4=N  | last5=Suzuki  | first5=T  | last6=Gonoi  | first6=T | last7=Seino  | first7=S  | last8=Takata  | first8=K }}
*{{cite journal  | author=Erginel-Unaltuna N, Yang WP, Blanar MA |title=Genomic organization and expression of KCNJ8/Kir6.1, a gene encoding a subunit of an ATP-sensitive potassium channel. |journal=Gene |volume=211 |issue= 1 |pages= 71-8 |year= 1998 |pmid= 9573340 |doi= }}
*{{cite journal |vauthors=Erginel-Unaltuna N, Yang WP, Blanar MA |title=Genomic organization and expression of KCNJ8/Kir6.1, a gene encoding a subunit of an ATP-sensitive potassium channel |journal=Gene |volume=211 |issue= 1 |pages= 71–78 |year= 1998 |pmid= 9573340 |doi=10.1016/S0378-1119(98)00086-9  }}
*{{cite journal  | author=Surah-Narwal S, Xu SZ, McHugh D, ''et al.'' |title=Block of human aorta Kir6.1 by the vascular KATP channel inhibitor U37883A. |journal=Br. J. Pharmacol. |volume=128 |issue= 3 |pages= 667-72 |year= 1999 |pmid= 10516647 |doi= 10.1038/sj.bjp.0702862 }}
*{{cite journal  | author=Surah-Narwal S |title=Block of human aorta Kir6.1 by the vascular KATP channel inhibitor U37883A |journal=Br. J. Pharmacol. |volume=128 |issue= 3 |pages= 667–672 |year= 1999 |pmid= 10516647 |doi= 10.1038/sj.bjp.0702862  | pmc=1571700 |name-list-format=vanc| author2=Xu SZ  | author3=McHugh D  | display-authors=3  | last4=McDonald  | first4=R L  | last5=Hough  | first5=E  | last6=Cheong | first6=A | last7=Partridge  | first7=C  | last8=Sivaprasadarao  | first8=A  | last9=Beech  | first9=D J }}
*{{cite journal | author=Tucker SJ, Ashcroft FM |title=Mapping of the physical interaction between the intracellular domains of an inwardly rectifying potassium channel, Kir6.2. |journal=J. Biol. Chem. |volume=274 |issue= 47 |pages= 33393-7 |year= 1999 |pmid= 10559219 |doi= }}
*{{cite journal  |vauthors=Tucker SJ, Ashcroft FM |title=Mapping of the physical interaction between the intracellular domains of an inwardly rectifying potassium channel, Kir6.2 |journal=J. Biol. Chem. |volume=274 |issue= 47 |pages= 33393–33397 |year= 1999 |pmid= 10559219 |doi=10.1074/jbc.274.47.33393  }}
*{{cite journal | author=Kono Y, Horie M, Takano M, ''et al.'' |title=The properties of the Kir6.1-6.2 tandem channel co-expressed with SUR2A. |journal=Pflugers Arch. |volume=440 |issue= 5 |pages= 692-8 |year= 2001 |pmid= 11007308 |doi=  }}
*{{cite journal  | author=Kono Y |title=The properties of the Kir6.1-6.2 tandem channel co-expressed with SUR2A |journal=Pflugers Arch. |volume=440 |issue= 5 |pages= 692–698 |year= 2001 |pmid= 11007308 |doi=10.1007/s004240000315 |name-list-format=vanc| author2=Horie M  | author3=Takano M  | display-authors=3  | last4=Otani  | first4=Hideo  | last5=Xie  | first5=Lai-Hua  | last6=Akao  | first6=M.  | last7=Tsuji  | first7=Keiko  | last8=Sasayama  | first8=Shigetake  }}
*{{cite journal | author=Cui Y, Giblin JP, Clapp LH, Tinker A |title=A mechanism for ATP-sensitive potassium channel diversity: Functional coassembly of two pore-forming subunits. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 2 |pages= 729-34 |year= 2001 |pmid= 11136227 |doi= 10.1073/pnas.011370498 }}
*{{cite journal  |vauthors=Cui Y, Giblin JP, Clapp LH, Tinker A |title=A mechanism for ATP-sensitive potassium channel diversity: Functional coassembly of two pore-forming subunits |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 2 |pages= 729–734 |year= 2001 |pmid= 11136227 |doi= 10.1073/pnas.011370498  | pmc=14656 }}
*{{cite journal | author=Liu Y, Ren G, O'Rourke B, ''et al.'' |title=Pharmacological comparison of native mitochondrial K(ATP) channels with molecularly defined surface K(ATP) channels. |journal=Mol. Pharmacol. |volume=59 |issue= 2 |pages= 225-30 |year= 2001 |pmid= 11160857 |doi=  }}
*{{cite journal  | author=Liu Y |title=Pharmacological comparison of native mitochondrial K(ATP) channels with molecularly defined surface K(ATP) channels |journal=Mol. Pharmacol. |volume=59 |issue= 2 |pages= 225–30 |year= 2001 |pmid= 11160857 |doi=  |name-list-format=vanc| author2=Ren G | author3=O'Rourke B  | display-authors=3  | last4=Marbán  | first4=E  | last5=Seharaseyon  | first5=J  }}
*{{cite journal | author=Giblin JP, Cui Y, Clapp LH, Tinker A |title=Assembly limits the pharmacological complexity of ATP-sensitive potassium channels. |journal=J. Biol. Chem. |volume=277 |issue= 16 |pages= 13717-23 |year= 2002 |pmid= 11825905 |doi= 10.1074/jbc.M112209200 }}
*{{cite journal  |vauthors=Giblin JP, Cui Y, Clapp LH, Tinker A |title=Assembly limits the pharmacological complexity of ATP-sensitive potassium channels |journal=J. Biol. Chem. |volume=277 |issue= 16 |pages= 13717–13723 |year= 2002 |pmid= 11825905 |doi= 10.1074/jbc.M112209200 }}
*{{cite journal  | author=Vanoye CG, MacGregor GG, Dong K, ''et al.'' |title=The carboxyl termini of K(ATP) channels bind nucleotides. |journal=J. Biol. Chem. |volume=277 |issue= 26 |pages= 23260-70 |year= 2002 |pmid= 11956191 |doi= 10.1074/jbc.M112004200 }}
*{{cite journal  | author=Vanoye CG |title=The carboxyl termini of K(ATP) channels bind nucleotides |journal=J. Biol. Chem. |volume=277 |issue= 26 |pages= 23260–23270 |year= 2002 |pmid= 11956191 |doi= 10.1074/jbc.M112004200  |name-list-format=vanc| author2=MacGregor GG  | author3=Dong K  | display-authors=3  | last4=Tang  | first4=L | last5=Buschmann  | first5=AS  | last6=Hall  | first6=AE  | last7=Lu  | first7=M  | last8=Giebisch  | first8=G  | last9=Hebert  | first9=SC }}
*{{cite journal | author=Miki T, Suzuki M, Shibasaki T, ''et al.'' |title=Mouse model of Prinzmetal angina by disruption of the inward rectifier Kir6.1. |journal=Nat. Med. |volume=8 |issue= 5 |pages= 466-72 |year= 2002 |pmid= 11984590 |doi= 10.1038/nm0502-466 }}
*{{cite journal  | author=Miki T |title=Mouse model of Prinzmetal angina by disruption of the inward rectifier Kir6.1 |journal=Nat. Med. |volume=8 |issue= 5 |pages= 466–472 |year= 2002 |pmid= 11984590 |doi= 10.1038/nm0502-466  |name-list-format=vanc| author2=Suzuki M  | author3=Shibasaki T  | display-authors=3  | last4=Uemura  | first4=Hiroko  | last5=Sato  | first5=Toshiaki  | last6=Yamaguchi  | first6=Kaori  | last7=Koseki  | first7=Haruhiko  | last8=Iwanaga  | first8=Toshihiko  | last9=Nakaya  | first9=Haruaki }}
*{{cite journal  | author=Nakamura K, Hirano J, Itazawa S, Kubokawa M |title=Protein kinase G activates inwardly rectifying K(+) channel in cultured human proximal tubule cells. |journal=Am. J. Physiol. Renal Physiol. |volume=283 |issue= 4 |pages= F784-91 |year= 2002 |pmid= 12217870 |doi= 10.1152/ajprenal.00023.2002 }}
*{{cite journal  |vauthors=Nakamura K, Hirano J, Itazawa S, Kubokawa M |title=Protein kinase G activates inwardly rectifying K(+) channel in cultured human proximal tubule cells |journal=Am. J. Physiol. Renal Physiol. |volume=283 |issue= 4 |pages= F784–91 |year= 2002 |pmid= 12217870 |doi= 10.1152/ajprenal.00023.2002 }}
*{{cite journal  | author=Curley M, Cairns MT, Friel AM, ''et al.'' |title=Expression of mRNA transcripts for ATP-sensitive potassium channels in human myometrium. |journal=Mol. Hum. Reprod. |volume=8 |issue= 10 |pages= 941-5 |year= 2003 |pmid= 12356945 |doi=  }}
*{{cite journal  | author=Curley M |title=Expression of mRNA transcripts for ATP-sensitive potassium channels in human myometrium |journal=Mol. Hum. Reprod. |volume=8 |issue= 10 |pages= 941–945 |year= 2003 |pmid= 12356945 |doi=10.1093/molehr/8.10.941  |name-list-format=vanc| author2=Cairns MT  | author3=Friel AM  | display-authors=3  | last4=McMeel  | first4=OM  | last5=Morrison  | first5=JJ  | last6=Smith  | first6=TJ  }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–16903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Singh H, Hudman D, Lawrence CL, ''et al.'' |title=Distribution of Kir6.0 and SUR2 ATP-sensitive potassium channel subunits in isolated ventricular myocytes. |journal=J. Mol. Cell. Cardiol. |volume=35 |issue= 5 |pages= 445-59 |year= 2004 |pmid= 12738227 |doi= }}
*{{cite journal  | author=Singh H |title=Distribution of Kir6.0 and SUR2 ATP-sensitive potassium channel subunits in isolated ventricular myocytes |journal=J. Mol. Cell. Cardiol. |volume=35 |issue= 5 |pages= 445–459 |year= 2004 |pmid= 12738227 |doi=10.1016/S0022-2828(03)00041-5  |name-list-format=vanc| author2=Hudman D  | author3=Lawrence CL  | display-authors=3  | last4=Rainbow  | first4=RD  | last5=Lodwick  | first5=D  | last6=Norman  | first6=RI  }}
*{{cite journal  | author=Insuk SO, Chae MR, Choi JW, ''et al.'' |title=Molecular basis and characteristics of KATP channel in human corporal smooth muscle cells. |journal=Int. J. Impot. Res. |volume=15 |issue= 4 |pages= 258-66 |year= 2003 |pmid= 12934053 |doi= 10.1038/sj.ijir.3901013 }}
*{{cite journal  | author=Insuk SO |title=Molecular basis and characteristics of KATP channel in human corporal smooth muscle cells |journal=Int. J. Impot. Res. |volume=15 |issue= 4 |pages= 258–266 |year= 2003 |pmid= 12934053 |doi= 10.1038/sj.ijir.3901013  |name-list-format=vanc| author2=Chae MR  | author3=Choi JW  | display-authors=3  | last4=Yang  | first4=D K  | last5=Sim  | first5=J H  | last6=Lee  | first6=S W }}
*{{cite journal | author=Emanuele E, Falcone C, Carabela M, ''et al.'' |title=Absence of Kir6.1/KCNJ8 mutations in Italian patients with abnormal coronary vasomotion. |journal=Int. J. Mol. Med. |volume=12 |issue= 4 |pages= 509-12 |year= 2004 |pmid= 12964027 |doi= }}
*{{cite journal  | author=Emanuele E |title=Absence of Kir6.1/KCNJ8 mutations in Italian patients with abnormal coronary vasomotion |journal=Int. J. Mol. Med. |volume=12 |issue= 4 |pages= 509–12 |year= 2004 |pmid= 12964027 |doi=  10.3892/ijmm.12.4.509|name-list-format=vanc| author2=Falcone C  | author3=Carabela M  | display-authors=3  | last4=Minoretti  | first4=P  | last5=d'Angelo  | first5=A  | last6=Montagna  | first6=L  | last7=Geroldi  | first7=D  }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–2127 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
}}
}}
{{refend}}
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* {{MeshName|KCNJ8+protein,+human}}
* {{MeshName|KCNJ8+protein,+human}}


{{membrane-protein-stub}}
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{{Ion channels}}
{{Ion channels|g3}}
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[[Category:Ion channels]]
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Revision as of 06:15, 2 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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Wikidata
View/Edit Human

Potassium inwardly-rectifying channel, subfamily J, member 8, also known as KCNJ8, is a human gene encoding the Kir6.1 protein.[1] A mutation in KCNJ8 has been associated with cardiac arrest in the early repolarization syndrome.

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. Kir6.1 is an integral membrane protein and inward-rectifier type potassium channel. Kir6.1, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins.[1]

See also

References

  1. ↑ 1.0 1.1 "Entrez Gene: KCNJ8 potassium inwardly-rectifying channel, subfamily J, member 8".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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