KCND3

Potassium voltage-gated channel, Shal-related subfamily, member 3
PDB rendering based on 1s1g.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1s1g​, 2i2r​, 2nz0​
Identifiers
Symbols	KCND3 ; KCND3L; KCND3S; KSHIVB; KV4.3; MGC142035; MGC142037
External IDs	Template:OMIM5 Template:MGI HomoloGene: 21036
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Potassium voltage-gated channel, Shal-related subfamily, member 3, also known as KCND3 or K_v4.3, is a human gene.

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member includes two isoforms with different sizes, which are encoded by alternatively spliced transcript variants of this gene.

See also

• Voltage-gated potassium channel

Further reading

• Gutman GA, Chandy KG, Grissmer S; et al. (2006). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol. Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Serôdio P, Vega-Saenz de Miera E, Rudy B (1997). "Cloning of a novel component of A-type K+ channels operating at subthreshold potentials with unique expression in heart and brain". J. Neurophysiol. 75 (5): 2174–9. PMID 8734615.CS1 maint: Multiple names: authors list (link)
• Kong W, Po S, Yamagishi T; et al. (1999). "Isolation and characterization of the human gene encoding Ito: further diversity by alternative mRNA splicing". Am. J. Physiol. 275 (6 Pt 2): H1963–70. PMID 9843794.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dilks D, Ling HP, Cockett M; et al. (1999). "Cloning and expression of the human kv4.3 potassium channel". J. Neurophysiol. 81 (4): 1974–7. PMID 10200233.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Isbrandt D, Leicher T, Waldschütz R; et al. (2000). "Gene structures and expression profiles of three human KCND (Kv4) potassium channels mediating A-type currents I(TO) and I(SA)". Genomics. 64 (2): 144–54. doi:10.1006/geno.2000.6117. PMID 10729221.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Postma AV, Bezzina CR, de Vries JF; et al. (2000). "Genomic organisation and chromosomal localisation of two members of the KCND ion channel family, KCND2 and KCND3". Hum. Genet. 106 (6): 614–9. PMID 10942109.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Deschênes I, Tomaselli GF (2002). "Modulation of Kv4.3 current by accessory subunits". FEBS Lett. 528 (1–3): 183–8. PMID 12297301.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ren X, Shand SH, Takimoto K (2003). "Effective association of Kv channel-interacting proteins with Kv4 channel is mediated with their unique core peptide". J. Biol. Chem. 278 (44): 43564–70. doi:10.1074/jbc.M302337200. PMID 12928444.CS1 maint: Multiple names: authors list (link)
• Hatano N, Ohya S, Muraki K; et al. (2004). "Two arginines in the cytoplasmic C-terminal domain are essential for voltage-dependent regulation of A-type K+ current in the Kv4 channel subfamily". J. Biol. Chem. 279 (7): 5450–9. doi:10.1074/jbc.M302034200. PMID 14645239.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Scannevin RH, Wang K, Jow F; et al. (2004). "Two N-terminal domains of Kv4 K(+) channels regulate binding to and modulation by KChIP1". Neuron. 41 (4): 587–98. PMID 14980207.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zicha S, Xiao L, Stafford S; et al. (2005). "Transmural expression of transient outward potassium current subunits in normal and failing canine and human hearts". J. Physiol. (Lond.). 561 (Pt 3): 735–48. doi:10.1113/jphysiol.2004.075861. PMID 15498806.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Frank-Hansen R, Larsen LA, Andersen P; et al. (2005). "Mutations in the genes KCND2 and KCND3 encoding the ion channels Kv4.2 and Kv4.3, conducting the cardiac fast transient outward current (ITO,f), are not a frequent cause of long QT syndrome". Clin. Chim. Acta. 351 (1–2): 95–100. doi:10.1016/j.cccn.2004.08.017. PMID 15563876.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Baltaev R, Strutz-Seebohm N, Korniychuk G; et al. (2005). "Regulation of cardiac shal-related potassium channel Kv 4.3 by serum- and glucocorticoid-inducible kinase isoforms in Xenopus oocytes". Pflugers Arch. 450 (1): 26–33. doi:10.1007/s00424-004-1369-z. PMID 15578212.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Radicke S, Cotella D, Graf EM; et al. (2005). "Expression and function of dipeptidyl-aminopeptidase-like protein 6 as a putative beta-subunit of human cardiac transient outward current encoded by Kv4.3". J. Physiol. (Lond.). 565 (Pt 3): 751–6. doi:10.1113/jphysiol.2005.087312. PMID 15890703.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gregory SG, Barlow KF, McLay KE; et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lundby A, Olesen SP (2006). "KCNE3 is an inhibitory subunit of the Kv4.3 potassium channel". Biochem. Biophys. Res. Commun. 346 (3): 958–67. doi:10.1016/j.bbrc.2006.06.004. PMID 16782062.
• Ahmed I, Cosen-Binker LI, Leung YM; et al. (2007). "Modulation of the K(v)4.3 channel by syntaxin 1A". Biochem. Biophys. Res. Commun. 358 (3): 789–95. doi:10.1016/j.bbrc.2007.04.182. PMID 17506992.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Potapova IA, Cohen IS, Doronin SV (2007). "Voltage-gated ion channel Kv4.3 is associated with Rap guanine nucleotide exchange factors and regulates angiotensin receptor type 1 signaling to small G-protein Rap". FEBS J. 274 (17): 4375–84. doi:10.1111/j.1742-4658.2007.05966.x. PMID 17725712.CS1 maint: Multiple names: authors list (link)

External links

• Kv4.3+Potassium+Channel at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.