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==Overview==
==Overview==
Gallstone disease must be differentiated from other diseases that cause  (right upper quadrant) such as: [[Gastroesophageal reflux disease|gastroesophageal reflux disorder]], [[peptic ulcer|peptic ulcer disease]],[[hepatitis]],[[sphincter of Oddi dysfunction]],[[appendicitis]], bile duct stricture, [[chronic pancreatitis]], [[irritable bowel syndrome]], [[coronary heart disease|ischemic heart disease]], [[pyelonephritis]], [[ureter|ureteral]] calculi and complications of gallstone disease include: [[cholecystitis|acute cholecystitis]], [[choledocholithiasis]], [[acute pancreatitis]], and acute [[cholangitis]].<ref name="pmid16844493">{{cite journal |vauthors=Portincasa P, Moschetta A, Palasciano G |title=Cholesterol gallstone disease |journal=Lancet |volume=368 |issue=9531 |pages=230–9 |year=2006 |pmid=16844493 |doi=10.1016/S0140-6736(06)69044-2 |url=}}</ref><ref name="pmid19524793">{{cite journal |vauthors=Center SA |title=Diseases of the gallbladder and biliary tree |journal=Vet. Clin. North Am. Small Anim. Pract. |volume=39 |issue=3 |pages=543–98 |year=2009 |pmid=19524793 |doi=10.1016/j.cvsm.2009.01.004 |url=}}</ref>
Gallstone disease must be differentiated from other diseases that cause  (right upper quadrant) such as: [[Gastroesophageal reflux disease|gastroesophageal reflux disorder]], [[peptic ulcer|peptic ulcer disease]],[[hepatitis]],[[sphincter of Oddi dysfunction]],[[appendicitis]], bile duct stricture, [[chronic pancreatitis]], [[irritable bowel syndrome]], [[coronary heart disease|ischemic heart disease]], [[pyelonephritis]], [[ureter|ureteral]] calculi and complications of gallstone disease include: [[cholecystitis|acute cholecystitis]], [[choledocholithiasis]], [[acute pancreatitis]], and acute [[cholangitis]].


==Differentiating Gallstone disease from other Diseases==
==Differentiating Gallstone disease from other Diseases==


As Gallstone disease manifests in a variety of clinical forms, differentiation must be established in accordance with the particular subtype of gallstones. The presence of biliary colic is an important diagnostic feature to distinguish between gallstones and non-biliary disorders. It has been shown that patients who present with biliary colic are more likely to have gallstones on imaging. <ref name="pmid7638565">{{cite journal |vauthors=Kraag N, Thijs C, Knipschild P |title=Dyspepsia--how noisy are gallstones? A meta-analysis of epidemiologic studies of biliary pain, dyspeptic symptoms, and food intolerance |journal=Scand. J. Gastroenterol. |volume=30 |issue=5 |pages=411–21 |year=1995 |pmid=7638565 |doi= |url=}}</ref>  
Gallstone disease can manifest in a variety of clinical forms. The presence of biliary colic is an important diagnostic feature to distinguish between gallstones and non-biliary stone disorders. Studies have shown evidence that patients who present with biliary colic are more likely to have gallstones detected on imaging. <ref name="pmid7638565">{{cite journal |vauthors=Kraag N, Thijs C, Knipschild P |title=Dyspepsia--how noisy are gallstones? A meta-analysis of epidemiologic studies of biliary pain, dyspeptic symptoms, and food intolerance |journal=Scand. J. Gastroenterol. |volume=30 |issue=5 |pages=411–21 |year=1995 |pmid=7638565 |doi= |url=}}</ref>  
'''However, it is important to note that biliary colic can be concomitant in patients with other biliary disorders such as [[Cholecystitis|acute cholecystitis]], [[choledocholithiasis]], [[sphincter of Oddi dysfunction]], and functional gallbladder disorder.'''  
'''However, it is important to note that biliary colic can be concomitant in patients with other biliary disorders such as [[Cholecystitis|acute cholecystitis]], [[choledocholithiasis]], [[sphincter of Oddi dysfunction]], and functional gallbladder disorder.'''<ref name="pmid16844493">{{cite journal |vauthors=Portincasa P, Moschetta A, Palasciano G |title=Cholesterol gallstone disease |journal=Lancet |volume=368 |issue=9531 |pages=230–9 |year=2006 |pmid=16844493 |doi=10.1016/S0140-6736(06)69044-2 |url=}}</ref><ref name="pmid19524793">{{cite journal |vauthors=Center SA |title=Diseases of the gallbladder and biliary tree |journal=Vet. Clin. North Am. Small Anim. Pract. |volume=39 |issue=3 |pages=543–98 |year=2009 |pmid=19524793 |doi=10.1016/j.cvsm.2009.01.004 |url=}}</ref>


Laboratory studies can be helpful, along side clinical presentation in making a preliminary diagnosis:
*Liver biochemical tests (serum [[aminotransferases]], total [[bilirubin]], [[alkaline phosphatase]]), which may be abnormal in patients with [[hepatitis]], biliary tract obstruction, or (less commonly) acute [[cholecystitis]]
*Serum [[amylase]] and [[lipase]], which are elevated in [[acute pancreatitis]]
*[[Complete blood count|Complete blood count,]] which may show an elevated [[White blood cell|white blood cell count]] in patients with acute [[cholecystitis]] or acute [[cholangitis]]
*Urine analysis, which may show indicate a [[urinary tract infection]] or ureteral [[calculi]]<ref name="pmid23533021">{{cite journal |vauthors=Poupon R, Rosmorduc O, Boëlle PY, Chrétien Y, Corpechot C, Chazouillères O, Housset C, Barbu V |title=Genotype-phenotype relationships in the low-phospholipid-associated cholelithiasis syndrome: a study of 156 consecutive patients |journal=Hepatology |volume=58 |issue=3 |pages=1105–10 |year=2013 |pmid=23533021 |doi=10.1002/hep.26424 |url=}}</ref>
Other tests that may be indicated depending upon the patient's symptoms and history includes:
*Upper [[endoscopy]] to look for [[Peptic ulcer|peptic ulcer disease]]
*Endoscopic [[Medical ultrasonography|ultrasonography]] to look for [[chronic pancreatitis]]
*[[Endoscopic retrograde cholangiopancreatography|Endoscopic retrograde cholangiopancreatography (ERCP)]] with [[sphincter of Oddi]] [[Pressure measurement|manometry]] to look for [[sphincter of Oddi dysfunction]]
*[[HIDA scan|Cholescintigraphy]] with or without [[cholecystokinin]] (CCK)-stimulation to look for acute [[cholecystitis]] and functional gallbladder disorder, respectively
*Testing for [[Coronary heart disease|ischemic heart disease]]
*[[Esophageal motility study|Esophageal manometry]] to look for esophageal sources of chest pain, such as [[Diffuse esophageal spasm (patient information)|esophageal spasm]]<ref name="pmid15802102">{{cite journal |vauthors=Shaffer EA |title=Epidemiology and risk factors for gallstone disease: has the paradigm changed in the 21st century? |journal=Curr Gastroenterol Rep |volume=7 |issue=2 |pages=132–40 |year=2005 |pmid=15802102 |doi= |url=}}</ref><ref name="pmid26895902">{{cite journal |vauthors=Julliard O, Hauters P, Possoz J, Malvaux P, Landenne J, Gherardi D |title=Incisional hernia after single-incision laparoscopic cholecystectomy: incidence and predictive factors |journal=Surg Endosc |volume=30 |issue=10 |pages=4539–43 |year=2016 |pmid=26895902 |doi=10.1007/s00464-016-4790-4 |url=}}</ref>


==Differential diagnosis==
==Differential diagnosis==


The differential diagnosis of diseases presenting with abdominal pain, fever and jaundice is discussed below.
The differential diagnosis of diseases presenting with abdominal pain, fever and jaundice is discussed below.
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<span style="font-size:85%">'''Abbreviations:'''
<span style="font-size:85%">'''Abbreviations:'''

Revision as of 18:01, 7 December 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Hadeel Maksoud M.D.[2]

Overview

Gallstone disease must be differentiated from other diseases that cause (right upper quadrant) such as: gastroesophageal reflux disorder, peptic ulcer disease,hepatitis,sphincter of Oddi dysfunction,appendicitis, bile duct stricture, chronic pancreatitis, irritable bowel syndrome, ischemic heart disease, pyelonephritis, ureteral calculi and complications of gallstone disease include: acute cholecystitis, choledocholithiasis, acute pancreatitis, and acute cholangitis.

Differentiating Gallstone disease from other Diseases

Gallstone disease can manifest in a variety of clinical forms. The presence of biliary colic is an important diagnostic feature to distinguish between gallstones and non-biliary stone disorders. Studies have shown evidence that patients who present with biliary colic are more likely to have gallstones detected on imaging. [1] However, it is important to note that biliary colic can be concomitant in patients with other biliary disorders such as acute cholecystitis, choledocholithiasis, sphincter of Oddi dysfunction, and functional gallbladder disorder.[2][3]


Differential diagnosis

The differential diagnosis of diseases presenting with abdominal pain, fever and jaundice is discussed below. Abbreviations: RUQ= Right upper quadrant of the abdomen, LUQ= Left upper quadrant, LLQ= Left lower quadrant, RLQ= Right lower quadrant, LFT= Liver function test, SIRS= Systemic inflammatory response syndrome, ERCP= Endoscopic retrograde cholangiopancreatography, IV= Intravenous, N= Normal, AMA= Anti mitochondrial antibodies, LDH= Lactate dehydrogenase, GI= Gastrointestinal, CXR= Chest X ray, IgA= Immunoglobulin A, IgG= Immunoglobulin G, IgM= Immunoglobulin M, CT= Computed tomography, PMN= Polymorphonuclear cells, ESR= Erythrocyte sedimentation rate, CRP= C-reactive protein, TS= Transferrin saturation, SF= Serum Ferritin, SMA= Superior mesenteric artery, SMV= Superior mesenteric vein, ECG= Electrocardiogram

Classification of pain in the abdomen based on etiology Disease Clinical manifestations Diagnosis Comments
Symptoms Signs
Abdominal Pain Fever Rigors and chills Jaundice Diarrhea GI Bleed Hypo-

tension

Guarding Rebound Tenderness Bowel sounds Lab Findings Imaging
Abdominal causes Inflammatory causes Pancreato-biliary disorders Acute suppurative cholangitis RUQ + + + + + + N
  • Abnormal LFT
  • WBC >10,000
Ultrasound shows biliary dilatation/stents/tumor Septic shock occurs with features of SIRS
Acute cholangitis RUQ + + N Ultrasound shows biliary dilatation/stents/tumor Biliary drainage (ERCP) + IV antibiotics
Acute cholecystitis RUQ + + Hypoactive Ultrasound shows gallstone and evidence of inflammation Murphy’s sign
Acute pancreatitis Epigastric + ± ± + + N
  • Ultrasound shows evidence of inflammation
  • CT scan shows severity of pancreatitis
Pain radiation to back
Primary sclerosing cholangitis RUQ + + N ERCP and MRCP shows
  • Multiple segmental strictures
  • Mural irregularities
  • Biliary dilatation and diverticula
  • Distortion of biliary tree
The risk of cholangiocarcinoma in patients with primary sclerosing cholangitis is 400 times higher than the risk in the general population.
Cholelithiasis RUQ/Epigastric ± ± N to hyperactive for dislodged stone Ultrasound shows gallstone Fatty food intolerance
Gastric causes Gastrointestinal perforation Diffuse + ± ± +, depends on site + + ± Hyperactive/hypoactive
  • WBC> 10,000
Air under diaphragm in upright CXR Hamman's sign
Intestinal causes Inflammatory bowel disease Diffuse ± ± ± Hematochezia N/ Hyperactive String sign on abdominal x-ray in Crohn's disease

Extra intestinal findings:

Whipple's disease Diffuse ± ± + ± N Endoscopy is used to confirm diagnosis.

Images used to find complications

Extra intestinal findings:
Hepatic causes Viral hepatitis RUQ + + + in Hep A and E + in fulminant hepatitis +in acute + N
  • Abnormal LFTs
  • Viral serology
USG Hep A and E have fecoral route of transmission and Hep B and C transmits via blood transfusion and sexual contact.
Liver masses RUQ + + in Liver abscess ± + in Hepatocellular carcinoma + in sepsis + in Liver abscess + in Liver abscess N
  • CBC
  • LFTs
USG
Liver abscess RUQ + + + ± - + + ± Normal/hypoactive
  • US
  • CT
Hepatocellular carcinoma/Metastasis RUQ + - + - - - - -
  • Normal
  • Hyperactive if obstruction present
  • US
  • CT
  • Liver biopsy

Other symptoms:

Budd-Chiari syndrome RUQ ± ± + in liver failure leading to varices N
Findings on CT scan suggestive of Budd-Chiari syndrome include:
Ascitic fluid examination shows:
Peritoneal causes Spontaneous bacterial peritonitis Diffuse + + + in cirrhotic patients + ± + + Hypoactive
  • Ascitic fluid PMN>250 cells/mm³
  • Culture: Positive for single organism
Ultrasound for evaluation of liver cirrhosis

To review a differential diagnosis for abdominal pain, click here

References

  1. Kraag N, Thijs C, Knipschild P (1995). "Dyspepsia--how noisy are gallstones? A meta-analysis of epidemiologic studies of biliary pain, dyspeptic symptoms, and food intolerance". Scand. J. Gastroenterol. 30 (5): 411–21. PMID 7638565.
  2. Portincasa P, Moschetta A, Palasciano G (2006). "Cholesterol gallstone disease". Lancet. 368 (9531): 230–9. doi:10.1016/S0140-6736(06)69044-2. PMID 16844493.
  3. Center SA (2009). "Diseases of the gallbladder and biliary tree". Vet. Clin. North Am. Small Anim. Pract. 39 (3): 543–98. doi:10.1016/j.cvsm.2009.01.004. PMID 19524793.

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