Immunoglobulin G

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Overview

Immunoglobulin G (IgG) is a multimeric immunoglobulin, built of two heavy chains γ and two light chains. Each complex has two antigen binding sites. This is the most abundant immunoglobulin and is approximately equally distributed in blood and in tissue liquids, constituting 75% of serum immunoglobulins in humans.^[1]

In birds, IgG is often called IgY, and is found in serum and yolk.^[2]

Functions

This is the only isotype that can pass through the human placenta, thereby providing protection to the fetus in its first weeks of life before its own immune system has developed.

It can bind to many kinds of pathogens, for example viruses, bacteria, and fungi, and protects the body against them by complement activation (classic pathway), opsonization for phagocytosis and neutralisation of their toxins.

IgG can cause food allergy, and in such causes delayed-onset food allergy, in contrast to food allergy by IgE, whose effects appear rapidly.

Subclasses

Name	Percent	Crosses placenta easily	Complement activator	Binds to Fc receptors on phagocytic cells
IgG1	66%	yes	second highest	high affinity
IgG2	23%	no	third highest	extremely low affinity
IgG3	7%	yes	highest	high affinity
IgG4	4%	yes	no	intermediate affinity

Note: IgG affinity to Fc receptors on phagocytic cells is specific to individual species from which the antibody comes as well as the class.

See also

• Antibody
• IgM, IgA, IgD, IgE

External links

• A booklet with everything you wanted to know about IgG subclasses

References

1. ↑ Junqueira, Luiz C.; Jose Carneiro (2003). Basic Histology. McGraw-Hill. ISBN 0838505902. 
2. ↑ http://www.sigmaaldrich.com/Brands/Sigma_Genosys/Custom_Antisera/Key_Resources/Antisera_FAQ/Chicken_Antibody.html

v • d • e Immune system / Immunology
Systems	Adaptive immune system vs. Innate immune system • Humoral immune system vs. Cellular immune system • Complement system (Anaphylatoxins) • Intrinsic immune system
Antibodies and antigens	Antibody (Monoclonal antibodies, Polyclonal antibodies, Autoantibody) • Allotype • Isotype • Idiotype • Antigen (Superantigen)
Immune cells	White blood cells (T cell, B cell, NK cell, Mast cell, Basophil, Eosinophil) • Phagocyte (Neutrophil, Macrophage, Dendritic cell) • Antigen-presenting cell • Reticuloendothelial system
Immunity vs. tolerance	Immunity • Autoimmunity • Allergy • Tolerance (Central) • Immunodeficiency
Immunogenetics	Somatic hypermutation • V(D)J recombination • Immunoglobulin class switching • MHC / HLA
Substances	Cytokines • Opsonin • Cytolysin
Other	Inflammation • Epitope (Hapten) • Cross-reactivity

v • d • e Immune system proteins
Antibodies	Light chain, Heavy chain, IgA, IgD, IgE, IgG, IgM
Other	MAC complex - Nanobodies - Perforin

da:Immunoglobulin G

de:Immunglobulin Git:IgGfi:IgG

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Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .