'''Egl nine homolog 2''' is a [[protein]] that in humans is encoded by the ''EGLN2'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: EGLN2 egl nine homolog 2 (C. elegans)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=112398| accessdate = }}</ref> ELGN2 is a member of the non-haem Fe(II) and [[2-oxoglutarate (2OG)-dependent dioxygenases]].
'''Egl nine homolog 2''' is a [[protein]] that in humans is encoded by the ''EGLN2'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: EGLN2 egl nine homolog 2 (C. elegans)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=112398| accessdate = }}</ref> ELGN2 is a [[alpha-ketoglutarate-dependent hydroxylase]], a superfamily of non-haem iron-containing proteins.
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The hypoxia inducible factor (HIF) is a transcriptional complex which is involved in oxygen homeostasis. At normal oxygen levels, the alpha subunit of HIF is targeted for degradation by prolyl hydroxylation.
This gene encodes an enzyme responsible for this posttranslational modification. Multiple alternatively spliced variants, encoding the same protein, have been identified.[1]
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