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==Overview==
==Overview==
==Causes==
==Causes==
===Toxic Acute Tubular Necrosis ===
===Ischemic Acute Tubular Necrosis===
Toxic ATN can be caused by free [[hemoglobin]] or [[myoglobin]], by medication such as [[antibiotic]]s and cytostatic drugs, or by intoxication ([[ethylene glycol]], "anti-freeze").
Renal hypoperfusion is the major cause of ischemic ATN. A decrease in blood pressure to the extent that renal protective mechanisms fail to maintain adequate perfusion leads to ATP depletion and cell necrosis. Some etiologies associated with ischemic ATN include:
* Hypotension
* Sepsis
* Cardiogenic shock
* Renal vein thrombosis
* ACE inhibitors
* Angiotensin receptor blockers
* NSAIDs


===Ischemic Acute Tubular Necrosis===
Ischemic Acute Tubular Necrosis can be caused when the [[kidneys]] are not sufficiently perfused for a long period of time (i.e. [[renal artery stenosis]]) or during [[Shock (medical)|shock]]. [[Hypoperfusion]] can also be caused by [[embolism]] of the renal arteries.
Ischemic Acute Tubular Necrosis specifically causes ''skip lesions'' through the tubules.
==References==
==References==
{{reflist|2}}   
{{reflist|2}}   

Revision as of 19:36, 1 February 2014

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor-In-Chief: Cafer Zorkun, M.D., Ph.D. [2]

Overview

Causes

Ischemic Acute Tubular Necrosis

Renal hypoperfusion is the major cause of ischemic ATN. A decrease in blood pressure to the extent that renal protective mechanisms fail to maintain adequate perfusion leads to ATP depletion and cell necrosis. Some etiologies associated with ischemic ATN include:

  • Hypotension
  • Sepsis
  • Cardiogenic shock
  • Renal vein thrombosis
  • ACE inhibitors
  • Angiotensin receptor blockers
  • NSAIDs

References


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