Non-Hodgkin lymphoma (differentiating types of NHL)
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Preeti Singh, M.B.B.S.[2]
Overview
Non-Hodgkin lymphoma (differentiating types of NHL)
Differentiating different types of Non-Hodgkin lymphoma. Gold standard for differentiation different types of Non-Hodgkin lymphoma is Biopsy.
Category | Disease | Etiology | Clinical manifestations | Paraclinical findings | Gold standard | Associated findings | ||||||||||
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Lab findings | ||||||||||||||||
Symptoms | Signs | CBC | Immunochemistry | Histopathology | ||||||||||||
Constitutional symptoms | Rash | Abdominal pain | Diarrhea | Mass | Other | WBC | Hb | Plt | ||||||||
Hodgkin's Lymphoma | ||||||||||||||||
Non-Hodgkin's Lymphoma | ||||||||||||||||
Diffuse large B cell lymphoma[1][2][3] |
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↓ | ↓ | Nl to ↓ |
Centroblastic
Immunoblastic
Anaplastic
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B Cell Lymphoma | Mantle cell lymphoma |
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Abdominal distention |
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↓ | Nl to ↓ |
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B-lymphoblastic leukemia/lymphoma |
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+ | – | – | – |
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↓ | ↓ | Nl to ↓ |
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Follicular lymphoma |
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Only in 20% of patients: | + | + | ± |
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↓ | ↓ | Nl to ↓ |
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Lymph node biopsy |
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Burkitt lymphoma |
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B cell chronic lymphocytic leukemia/small lymphocytic lymphoma |
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Marginal zone lymphoma | Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) type |
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Splenic marginal zone lymphoma |
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Nodal marginal zone B-cell lymphoma |
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+ |
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Lymphoplasmacytic lymphoma (Waldenstrom’s macroglobulinemia) |
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Hairy cell leukemia |
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Category | Disease | Etiology | Constitutional symptoms | Rash | Abdominal pain | Diarrhea | Mass | Other | WBC | Hb | Plt | Immunochemistry | Histopathology | Gold standard | Associated findings | |
T cell lymphoma | Precursor T-cell lymphoblastic leukemia/lymphoma |
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Adult T cell leukemia/lymphoma |
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Anaplastic large cell lymphoma |
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Cutaneous T-cell lymphoma | Mycosis fungoides / Sézary syndrome |
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Peripheral T-cell lymphoma | Subcutaneous panniculitis-like T-cell lymphoma |
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Hepatosplenic gamma-delta T-cell lymphoma |
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Enteropathy-type intestinal T-cell lymphoma |
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Extranodal T-cell lymphoma, nasal type |
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Angioimmunoblastic T-cell lymphoma |
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Peripheral T-cell lymphoma, unspecified |
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- ↑ Choi, W. W.L.; Weisenburger, D. D.; Greiner, T. C.; Piris, M. A.; Banham, A. H.; Delabie, J.; Braziel, R. M.; Geng, H.; Iqbal, J.; Lenz, G.; Vose, J. M.; Hans, C. P.; Fu, K.; Smith, L. M.; Li, M.; Liu, Z.; Gascoyne, R. D.; Rosenwald, A.; Ott, G.; Rimsza, L. M.; Campo, E.; Jaffe, E. S.; Jaye, D. L.; Staudt, L. M.; Chan, W. C. (2009). "A New Immunostain Algorithm Classifies Diffuse Large B-Cell Lymphoma into Molecular Subtypes with High Accuracy". Clinical Cancer Research. 15 (17): 5494–502. doi:10.1158/1078-0432.CCR-09-0113. PMID 19706817.
- ↑ Colomo, L.; López-Guillermo, A; Perales, M; Rives, S; Martínez, A; Bosch, F; Colomer, D; Falini, B; Montserrat, E; Campo, E (2002). "Clinical impact of the differentiation profile assessed by immunophenotyping in patients with diffuse large B-cell lymphoma". Blood. 101 (1): 78–84. doi:10.1182/blood-2002-04-1286. PMID 12393466.
- ↑ Muris, JJF; Meijer, Cjlm; Vos, W; Van Krieken, Jhjm; Jiwa, NM; Ossenkoppele, GJ; Oudejans, JJ (2006). "Immunohistochemical profiling based on Bcl-2, CD10 and MUM1 expression improves risk stratification in patients with primary nodal diffuse large B cell lymphoma". The Journal of Pathology. 208 (5): 714–23. doi:10.1002/path.1924. PMID 16400625.