Non-Hodgkin lymphoma laboratory tests
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Shyam Patel [2]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [3]
Overview
Laboratory tests for non-Hodgkin lymphoma include complete blood count (CBC), blood chemistry studies, HIV blood test, and hepatitis B blood test.
Laboratory Tests
Laboratory tests for non-Hodgkin lymphoma include the following:[1][2][3]
Complete Blood Count
- In early stage of the disease the complete blood count (CBC) may be normal.
- Anemia may be seen secondary to involvement of bone marrow, autoimmune hemolysis and bleeding.
- Thrombocytopenia, leukopenia, or pancytopenia may be seen after bone marrow infiltration or autoimmune cytopenias.
- Lymphocytosis with circulating malignant cells seen in low grade lymphomas.
- Thrombocytosis may be seen as a paraneoplastic syndrome.
Blood Chemistry Studies
- Elevated lactate dehydrogenase (LDH) correlates with poor prognosis.
- Liver function test (LFT) results may be abnormal secondary to hepatic involvement.
- Hypercalcemia may be seen in patients with acute form of adult T-cell lymphoma-leukemia (ATLL).
Other Studies
- Increased levels of beta2-microglobulin level may be seen, which correlate with a poor prognosis.
- A positive Coombs test may be positive.
- Hypogammaglobulinemia may be present.
- HIV viral load and the antibody titre may be elevated.
- HTLV-1 serology should be obtained in patients with ATLL.
- HbsAg and Hep B antibody titre must be obtained.
References
- ↑ Sandlund JT (2015). "Non-Hodgkin Lymphoma in Children". Curr Hematol Malig Rep. 10 (3): 237–43. doi:10.1007/s11899-015-0277-y. PMID 26174528.
- ↑ Shankland KR, Armitage JO, Hancock BW (2012). "Non-Hodgkin lymphoma". Lancet. 380 (9844): 848–57. doi:10.1016/S0140-6736(12)60605-9. PMID 22835603.
- ↑ Hingorjo MR, Syed S (2008). "Presentation, staging and diagnosis of lymphoma: a clinical perspective". J Ayub Med Coll Abbottabad. 20 (4): 100–3. PMID 19999217.