Human urine

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Editor-In-Chief: Steven C. Campbell, M.D., Ph.D., Professor of Surgery, Residency Program Director, Section of Urologic Oncology, Glickman Urological and Kidney Institute, Cleveland Clinic. You can email Dr. Campbell by clicking here. Office phone: 216-444-5595.


Overview

Urine is liquid waste product of the body secreted by the kidneys by a process of filtration from blood and excreted through the urethra. This waste is eventually expelled from the body in a process known as urination.

Most commonly the excretion of urine serves for flushing waste molecules collected from the blood by the kidneys, and for the homeostasis of the body fluids.

Composition

Urine is the byproduct or fluid secreted by the kidneys, transported by the ureters to the urinary bladder where it is stored until it is voided through the urethra.

It is a transparent solution that is clear to amber in color, and is usually a light yellow color. Urine is made up of a watery solution of metabolic wastes (such as urea), dissolved salts and organic materials. Fluid and materials being filtered by the kidneys, destined to become urine, come from the blood or interstitial fluid.

The composition of urine is adjusted in the process of reabsorption when essential molecules needed by the body, such as glucose, are reabsorbed back into the blood stream via carrier molecules. The remaining fluid contains high concentrations of urea and other excess or potentially toxic substances that will be released from the body via urination. Urine flows through these structures: the kidney, ureter, bladder, and finally the urethra. Urine is produced by a process of filtration, reabsorption, and tubular secretion.

Urine contains large amounts of urea, an excellent source of nitrogen for plants. As such it is a useful accelerator for compost. Urea is much less toxic than ammonia and is formed by the indirect combination of the byproducts of deamination (2 NH3 molecules) and cellular respiration (1 CO2 molecule). Other components include various inorganic salts such as sodium chloride (sodium discharge is called natriuresis).


Chemical analysis

Urea structure

Here is a list of all substances contained in urine:

  • Non-organic substances in the urine: bicarbonate, chloride, phosphorus, sulphur, bromide, fluoride, iodide, rhodanide, potassium, natron, calcium, magnesium, iron, copper, zinc, cobalt, selenium, arsenium, lead, mercury.
  • Substances devoid of nitrogen in the urine: wide assortment of organic acids
  • Agglutinines and precipitines: neutralizing action on the polio virus and other viruses.
  • Antineoplaston: selectively prevents the development of cancer cells without affecting healthy cells that
  • Allantoin: nitrogen crystalline substance that promotes healing, from the oxidation of uric acid. It is used in the manufacture of many skin creams.
  • DHEA (dehydroepiandrosterone): steroid secreted by the adrenal glands, present in large quantities in male urine. It prevents obesity, prolongs the life of animals and is a possible treatment against anemia, diabetes and breast cancer. DHEA stimulates the development of the bone marrow and increases its production of red blood cells, monocytes, macrophages and lymphocytes. A low level of DHEA seems to be associated with aging.
  • Antisecretoires gastric: prevent the onset and development of stomach ulcers.
  • Acid glycuronique: produced by the liver, kidneys and intestines, it has a major secretory function.
  • H-11: inhibits the growth of cancer cells and reduces the existing tumors without disrupting the recovery process.
  • H.U.D. HUD (Human’s urine derivative) demonstrates remarkable anticancer properties.
  • Interleukin-1: a positive influence on the auxiliary and inhibitory substances. Can send a signal to the hypothalamus to trigger fever.
  • Trimethyl-glyoxal: destroys cancer cells.
  • Prostaglandine a hormonal substance that dilates the blood vessels, lowers tension, relaxes the muscle walls of the bronchi, stimulates contractions during labor, and many metabolic functions.
  • Proteoglobulines: plasma proteins containing anti-bodies against certain allergens, they are identical to the proteins of immoglobulines blood serum.
  • Prosteoses: immunological products assets allergic reactions.

Colour

The typical bright yellow colour of urine is caused by the pigment urochrome, but also from the degradation products of bilirubin and urobilin. Clear colors are a sign of hydration and are the preferred colors of urine.

Unusual colouration

  • Yellowing/light Orange may be caused by removal of excess B vitamins from the bloodstream.
  • Certain medications such as rifampin and pyridium can cause orange urine.
  • Bloody urine is termed hematuria and is a symptom that requires medical attention. (This could also be a sign of a bladder infection, which also requires medical attention)
  • Dark orange to brown urine can be a symptom of jaundice or Gilbert's syndrome.
  • Black or dark-colored urine is referred to as melanuria and may be caused by a melanoma.
  • Reddish or brown urine may be caused by porphyria.
  • Flourescent Yellow / Greenish urine may be caused by taking dietary supplemental vitamins
  • Dark yellow urine is usually caused by dehydration.

Turbidity

Turbid urine may be a symptom of a bacterial infection, but can also be due to crystallisation of salts in the urine (e.g. calcium phosphate), which will dissolve if acetic acid (vinegar) is added.

pH

The pH of urine is close to neutral, i.e. 7, but can normally vary between 4.5 and 8. Strongly acidic or alkaline urine may be a symptom of a disease.[1]

Amount

The amount of urine produced depends on numerous factors including state of hydration, activities, environmental factors, size, and health. In adult humans the average production is about 1 - 2 L per day. Producing too much or too little urine needs medical attention: Polyuria is a condition of excessive production of urine (> 2.5 L/day), in contrast to oliguria where < 400 mL are produced per day, or anuria with a production of < 100 mL per day.

Function

Main article: Renal physiology

Urination is the primary method for excreting toxins, chemicals and drugs from the body. These chemicals can be detected and analysed by urinalysis. Cellular metabolism results in a buildup of toxic nitrogen compounds, or nitrogenous waste. Since this waste is toxic, most animals have excretory systems (in humans this is known as the Urinary system, which consists of the Kidneys, Urinary bladder, Ureter, and Urethra) to rid themselves of this waste. The kidneys extract the nitrogenous wastes from the bloodstream, as well as excess water, sugars, and a variety of other chemicals.

In cases of kidney or urinary tract infection (UTI), the urine will contain bacteria, but otherwise urine is virtually sterile and nearly odorless when it leaves the body. However, after that, bacteria that contaminate the urine will convert chemicals in the urine into smelly chemicals that are responsible for the distinctive odor of stale urine; in particular, ammonia is produced from urea.

Some diseases alter the quantity and consistency of the urine, (e.g., sugar in the urine is a sign of diabetes).

Density or specific gravity

Normal urine density or specific gravity values vary between 1.003-1.035 (g.cm-3) , and any deviations may or may not be associated with urinary disorders.

Urine in medicine

Examination

Many physicians in history have resorted to the inspection and examination of the urine of their patients. Hippocrates described urine examination. Hermogenes wrote about the color and other attributes of urine as indicators of certain diseases. Abdul Malik Ibn Habib of Andalusia d.862CE, mentions numerous reports of urine examination throughout the Umayyad empire.[2] Diabetes mellitus got its name because the urine is plentiful and sweet. A urinalysis is a medical examination of the urine and part of routine examinations. A culture of the urine is performed when a urinary tract infection is suspected. A microscopic examination of the urine may be helpful to identify organic or inorganic substrates and help in the diagnosis.

The color and volume of urine can be reliable indicators of hydration level. Clear and copious urine is generally a sign of adequate hydration, dark urine is a sign of dehydration. The exception is when alcohol, caffeine, or other diuretics are consumed, in which case urine can be clear and copious and the person still be dehydrated.

Application

The use of urine therapy as a medical treatment or daily health regimen is uncommon. Aztec physicians used urine to clean external wounds to prevent infection, and administered it as a drink to relieve stomach and intestine problems. Purported beneficiaries of the 'urine cure' include Jim Morrison, and Steve McQueen. Its medicinal properties have also been used in China as a part of holistic medicine, and in India, especially as part of the traditional Indian medicine, Ayurveda, under the name Amaroli.

Resource

Urine may contain proteins or other substances that are useful for medical therapy. Urine from postmenopausal women is rich in gonadotropins that can yield follicle stimulating hormone and luteinizing hormone for fertility therapy. The first such commercial product was Pergonal. Urine from pregnant women contains enough human chorionic gonadotropins for commercial extraction and purification to produce hCG medication. Pregnant mare urine is the source of estrogens, namely Premarin.

In recent times, the Port-A-John corporation of Utica, Michigan, USA has developed a filter to collect medically significant proteins from users of their chemical toilets.

Other uses

Ancient uses

  • The ancient Romans used urine as a bleaching agent for cleaning clothes and teeth.
  • In Scotland, it was used to wash wool to prevent it from shrinking.

Survival uses

See also: Urophagia

Shipwrecked or people otherwise adrift at sea for long periods often resort to drinking their urine when no rainwater is available, seawater being unsuitable. People stranded in deserts often also drank urine to prevent life-threatening dehydration from setting in. However, this desperate measure achieves little to delay death from thirst as urine dehydrates one in the same manner saltwater does.

During World War I, the Germans experimented with numerous poisonous gases for use during war. After the first German chlorine gas attacks, Allied troops were supplied with masks of cotton pads that had been soaked in urine. It was believed that the ammonia in the pad neutralized the chlorine. These pads were held over the face until the soldiers could escape from the poisonous fumes, although it is now known that chlorine gas reacts with urine to produce toxic fumes.

Urine has also been historically used as an antiseptic. In times of war, when other antiseptics were unavailable, urine, the darker the better, was utilized on open wounds to kill bacteria.

Urban myth states that urine works well against jellyfish stings, although in reality it is at best ineffective and in some cases may actually make the injury worse.[3][4][5]

History

The yellow color of urine was previously thought to come from gold. Alchemists spent much time trying to extract gold from urine, and this led to discoveries such as white phosphorus, which was discovered by the German alchemist Hennig Brand in 1669 when he was distilling fermented urine. In 1773 the French chemist Hilaire Rouelle discovered the organic compound urea by boiling urine dry.

There are also reports surfacing recently that urine contains small amounts of OMRE/ORMUS style monoatomic transition metals (such as ruthenium, osmium, iridium, rhodium, palladium, platinum, gold, silver, copper, cobalt and nickel). Some claim these are found in very small amounts in normal drinking water, vegetables, fruits, meat, and other foods. We consume these inadvertently anytime we eat or drink. These claims have not been confirmed yet, because of the difficult task of analyzing ORME style elements.

References

  1. Urine pH
  2. Ibn Habib, Abdul Malik d.862CE/283AH "Kitaab Tib Al'Arab" (The Book of Arabian Medicine), Published by Dar Ibn Hazm, Beirut, Lebanon 2007(Arabic)
  3. ABC News: Old Wives' Tale? Urine as Jellyfish Sting Remedy
  4. Fact or Fiction?: Urinating on a Jellyfish Sting is an Effective Treatment: Scientific American
  5. Jellyfish Sting Treatment - How to Treat a Jellyfish Sting

See also

External links



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