Binswanger's disease

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Binswanger's disease
ICD-10 I67.3
ICD-9 290.12
DiseasesDB 1405
MeSH D015140

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Synonyms and keywords: Subcortical leukoencephalopathy; progressive vascular leukoencephalopathy; subcortical arteriosclerotic encephalopathy

Overview

Binswanger's disease is a rare form of multi-infarct dementia caused by damage to deep white brain matter. It is characterized by memory loss and intellectual function and by changes in mood. It is associated with longstanding hypertension.

Pathophysiology

The histologic findings are diffuse, irregular loss of axons and myelin accompanied by widespread gliosis. Small infarcts may be seen in the frontal lobes. The pathologic mechanism may be damage caused by severe atherosclerosis.

A patient with long term severe hypertension develops progressive dementia.

Risk Factors

Hypertension

Diagnosis

CT

CT scans of the head demonstrates a diffuse loss of deep hemispheric white matter.

Treatment

Binswanger's disease has no known treatment, let alone cure, although drugs used to treat high blood pressure, depression, arrhythmia and low blood pressure are used to treat the condition's symptoms.[1]

References

de:Subkortikale arteriosklerotische Enzephalopathie

no:Binswangers sykdom fi:Binswangerin tauti




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