ZNF384: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Zinc finger protein 384''' is a [[protein]] that in humans is encoded by the ''ZNF384'' [[gene]].<ref name="pmid9225980">{{cite journal | vauthors = Margolis RL, Abraham MR, Gatchell SB, Li SH, Kidwai AS, Breschel TS, Stine OC, Callahan C, McInnis MG, Ross CA | title = cDNAs with long CAG trinucleotide repeats from human brain | journal = Human Genetics | volume = 100 | issue = 1 | pages = 114–22 | date = Jul 1997 | pmid = 9225980 | pmc =  | doi = 10.1007/s004390050476 }}</ref><ref name="pmid11149472">{{cite journal | vauthors = Thunyakitpisal P, Alvarez M, Tokunaga K, Onyia JE, Hock J, Ohashi N, Feister H, Rhodes SJ, Bidwell JP | title = Cloning and functional analysis of a family of nuclear matrix transcription factors (NP/NMP4) that regulate type I collagen expression in osteoblasts | journal = Journal of Bone and Mineral Research | volume = 16 | issue = 1 | pages = 10–23 | date = Jan 2001 | pmid = 11149472 | pmc = | doi = 10.1359/jbmr.2001.16.1.10 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ZNF384 zinc finger protein 384| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=171017| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Zinc finger protein 384
| HGNCid = 11955
| Symbol = ZNF384
| AltSymbols =; NP; CAGH1; CAGH1A; CIZ; ERDA2; NMP4; TNRC1
| OMIM = 609951
| ECnumber = 
| Homologene = 15849
| MGIid = 2443203
| GeneAtlas_image1 = PBB_GE_ZNF384_212369_at_tn.png
| Function = {{GNF_GO|id=GO:0003676 |text = nucleic acid binding}} {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007399 |text = nervous system development}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 171017
    | Hs_Ensembl = ENSG00000126746
    | Hs_RefseqProtein = NP_001035005
    | Hs_RefseqmRNA = NM_001039916
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 12
    | Hs_GenLoc_start = 6646078
    | Hs_GenLoc_end = 6668881
    | Hs_Uniprot = Q8TF68
    | Mm_EntrezGene = 269800
    | Mm_Ensembl = ENSMUSG00000038346
    | Mm_RefseqmRNA = NM_175557
    | Mm_RefseqProtein = NP_780766
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 6
    | Mm_GenLoc_start = 124974858
    | Mm_GenLoc_end = 125003436
    | Mm_Uniprot = 
  }}
}}
'''Zinc finger protein 384''', also known as '''ZNF384''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ZNF384 zinc finger protein 384| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=171017| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a C2H2-type [[zinc finger]] protein, which may function as a [[transcription factor]]. This gene also contains long CAG trinucleotide repeats that encode consecutive glutamine residues. The protein appears to bind and regulate the promoters of the extracellular matrix genes [[MMP1]], [[MMP3]], [[MMP7]] and [[COL1A1]]. Studies in mouse suggest that ZNF384 may be part of a general mechanical pathway that couples cell construction and function during extracellular matrix remodeling. Alternative splicing results in multiple transcript variants.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = DISCONTINUED: LocusID 10601 was defined by accessions U80748 and U80760 which appear to have been annotated on the complementary strand. Splice junction sequences and EST evidence suggest that the more likely transcript in this region is AB070238.<ref name="entrez">{{cite web | title = Entrez Gene: ZNF384 zinc finger protein 384| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=171017| accessdate = }}</ref>
}}


==References==
== Clinical significance ==
{{reflist|2}}
 
==Further reading==
Recurrent rearrangements of this gene with the Ewing's sarcoma gene, [[EWSR1]] on chromosome 22, or with the [[TAF15]] gene on chromosome 17, or with the [[TCF3]] (E2A) gene on chromosome 19, have been observed in [[acute leukemia]].<ref name="entrez"/>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Matsuo MY, Asakawa S, Shimizu N, Kimura H, Nonaka M | title = Nucleotide sequence of the MHC class I genomic region of a teleost, the medaka (Oryzias latipes) | journal = Immunogenetics | volume = 53 | issue = 10-11 | pages = 930–40 | date = Feb 2002 | pmid = 11862394 | doi = 10.1007/s00251-001-0427-3 }}
| citations =
* {{cite journal | vauthors = Graflund M, Sorbe B, Karlsson M | title = MIB-1, p53, bcl-2, and WAF-1 expression in pelvic lymph nodes and primary tumors in early stage cervical carcinomas: correlation with clinical outcome | journal = International Journal of Oncology | volume = 20 | issue = 5 | pages = 1041–7 | date = May 2002 | pmid = 11956602 | doi = 10.3892/ijo.20.5.1041 }}
*{{cite journal | author=Margolis RL, Abraham MR, Gatchell SB, ''et al.'' |title=cDNAs with long CAG trinucleotide repeats from human brain. |journal=Hum. Genet. |volume=100 |issue= 1 |pages= 114-22 |year= 1997 |pmid= 9225980 |doi=  }}
* {{cite journal | vauthors = Martini A, La Starza R, Janssen H, Bilhou-Nabera C, Corveleyn A, Somers R, Aventin A, Foà R, Hagemeijer A, Mecucci C, Marynen P | title = Recurrent rearrangement of the Ewing's sarcoma gene, EWSR1, or its homologue, TAF15, with the transcription factor CIZ/NMP4 in acute leukemia | journal = Cancer Research | volume = 62 | issue = 19 | pages = 5408–12 | date = Oct 2002 | pmid = 12359745 | doi =  }}
*{{cite journal  | author=Thunyakitpisal P, Alvarez M, Tokunaga K, ''et al.'' |title=Cloning and functional analysis of a family of nuclear matrix transcription factors (NP/NMP4) that regulate type I collagen expression in osteoblasts. |journal=J. Bone Miner. Res. |volume=16 |issue= 1 |pages= 10-23 |year= 2001 |pmid= 11149472 |doi=  }}
* {{cite journal | vauthors = Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S | title = Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions | journal = Genome Research | volume = 14 | issue = 9 | pages = 1711–8 | date = Sep 2004 | pmid = 15342556 | pmc = 515316 | doi = 10.1101/gr.2435604 }}
*{{cite journal  | author=Matsuo MY, Asakawa S, Shimizu N, ''et al.'' |title=Nucleotide sequence of the MHC class I genomic region of a teleost, the medaka (Oryzias latipes). |journal=Immunogenetics |volume=53 |issue= 10-11 |pages= 930-40 |year= 2002 |pmid= 11862394 |doi= 10.1007/s00251-001-0427-3 }}
* {{cite journal | vauthors = La Starza R, Aventin A, Crescenzi B, Gorello P, Specchia G, Cuneo A, Angioni A, Bilhou-Nabera C, Boqué C, Foà R, Uyttebroeck A, Talmant P, Cimino G, Martelli MF, Marynen P, Mecucci C, Hagemeijer A | title = CIZ gene rearrangements in acute leukemia: report of a diagnostic FISH assay and clinical features of nine patients | journal = Leukemia | volume = 19 | issue = 9 | pages = 1696–9 | date = Sep 2005 | pmid = 15990865 | doi = 10.1038/sj.leu.2403842 }}
*{{cite journal | author=Graflund M, Sorbe B, Karlsson M |title=MIB-1, p53, bcl-2, and WAF-1 expression in pelvic lymph nodes and primary tumors in early stage cervical carcinomas: correlation with clinical outcome. |journal=Int. J. Oncol. |volume=20 |issue= 5 |pages= 1041-7 |year= 2002 |pmid= 11956602 |doi= }}
* {{cite journal | vauthors = Janssen H, Marynen P | title = Interaction partners for human ZNF384/CIZ/NMP4--zyxin as a mediator for p130CAS signaling? | journal = Experimental Cell Research | volume = 312 | issue = 7 | pages = 1194–204 | date = Apr 2006 | pmid = 16510139 | doi = 10.1016/j.yexcr.2006.02.001 }}
*{{cite journal | author=Martini A, La Starza R, Janssen H, ''et al.'' |title=Recurrent rearrangement of the Ewing's sarcoma gene, EWSR1, or its homologue, TAF15, with the transcription factor CIZ/NMP4 in acute leukemia. |journal=Cancer Res. |volume=62 |issue= 19 |pages= 5408-12 |year= 2002 |pmid= 12359745 |doi=  }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Suzuki Y, Yamashita R, Shirota M, ''et al.'' |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711-8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604 }}
*{{cite journal | author=La Starza R, Aventin A, Crescenzi B, ''et al.'' |title=CIZ gene rearrangements in acute leukemia: report of a diagnostic FISH assay and clinical features of nine patients. |journal=Leukemia |volume=19 |issue= 9 |pages= 1696-9 |year= 2005 |pmid= 15990865 |doi= 10.1038/sj.leu.2403842 }}
*{{cite journal | author=Janssen H, Marynen P |title=Interaction partners for human ZNF384/CIZ/NMP4--zyxin as a mediator for p130CAS signaling? |journal=Exp. Cell Res. |volume=312 |issue= 7 |pages= 1194-204 |year= 2006 |pmid= 16510139 |doi= 10.1016/j.yexcr.2006.02.001 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
== External links ==
{{WikiDoc Sources}}
* {{MeshName|ZNF384+protein,+human}}
 
{{NLM content}}
{{gene-12-stub}}
{{Transcription factors|g2}}
[[Category:Transcription factors]]

Latest revision as of 03:54, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

n/a

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Zinc finger protein 384 is a protein that in humans is encoded by the ZNF384 gene.[1][2][3]

Function

This gene encodes a C2H2-type zinc finger protein, which may function as a transcription factor. This gene also contains long CAG trinucleotide repeats that encode consecutive glutamine residues. The protein appears to bind and regulate the promoters of the extracellular matrix genes MMP1, MMP3, MMP7 and COL1A1. Studies in mouse suggest that ZNF384 may be part of a general mechanical pathway that couples cell construction and function during extracellular matrix remodeling. Alternative splicing results in multiple transcript variants.[3]

Clinical significance

Recurrent rearrangements of this gene with the Ewing's sarcoma gene, EWSR1 on chromosome 22, or with the TAF15 gene on chromosome 17, or with the TCF3 (E2A) gene on chromosome 19, have been observed in acute leukemia.[3]

References

  1. ↑ Margolis RL, Abraham MR, Gatchell SB, Li SH, Kidwai AS, Breschel TS, Stine OC, Callahan C, McInnis MG, Ross CA (Jul 1997). "cDNAs with long CAG trinucleotide repeats from human brain". Human Genetics. 100 (1): 114–22. doi:10.1007/s004390050476. PMID 9225980.
  2. ↑ Thunyakitpisal P, Alvarez M, Tokunaga K, Onyia JE, Hock J, Ohashi N, Feister H, Rhodes SJ, Bidwell JP (Jan 2001). "Cloning and functional analysis of a family of nuclear matrix transcription factors (NP/NMP4) that regulate type I collagen expression in osteoblasts". Journal of Bone and Mineral Research. 16 (1): 10–23. doi:10.1359/jbmr.2001.16.1.10. PMID 11149472.
  3. ↑ 3.0 3.1 3.2 "Entrez Gene: ZNF384 zinc finger protein 384".

Further reading

  • Matsuo MY, Asakawa S, Shimizu N, Kimura H, Nonaka M (Feb 2002). "Nucleotide sequence of the MHC class I genomic region of a teleost, the medaka (Oryzias latipes)". Immunogenetics. 53 (10–11): 930–40. doi:10.1007/s00251-001-0427-3. PMID 11862394.
  • Graflund M, Sorbe B, Karlsson M (May 2002). "MIB-1, p53, bcl-2, and WAF-1 expression in pelvic lymph nodes and primary tumors in early stage cervical carcinomas: correlation with clinical outcome". International Journal of Oncology. 20 (5): 1041–7. doi:10.3892/ijo.20.5.1041. PMID 11956602.
  • Martini A, La Starza R, Janssen H, Bilhou-Nabera C, Corveleyn A, Somers R, Aventin A, Foà R, Hagemeijer A, Mecucci C, Marynen P (Oct 2002). "Recurrent rearrangement of the Ewing's sarcoma gene, EWSR1, or its homologue, TAF15, with the transcription factor CIZ/NMP4 in acute leukemia". Cancer Research. 62 (19): 5408–12. PMID 12359745.
  • Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (Sep 2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Research. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
  • La Starza R, Aventin A, Crescenzi B, Gorello P, Specchia G, Cuneo A, Angioni A, Bilhou-Nabera C, Boqué C, Foà R, Uyttebroeck A, Talmant P, Cimino G, Martelli MF, Marynen P, Mecucci C, Hagemeijer A (Sep 2005). "CIZ gene rearrangements in acute leukemia: report of a diagnostic FISH assay and clinical features of nine patients". Leukemia. 19 (9): 1696–9. doi:10.1038/sj.leu.2403842. PMID 15990865.
  • Janssen H, Marynen P (Apr 2006). "Interaction partners for human ZNF384/CIZ/NMP4--zyxin as a mediator for p130CAS signaling?". Experimental Cell Research. 312 (7): 1194–204. doi:10.1016/j.yexcr.2006.02.001. PMID 16510139.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Retrieved from "https://www.wikidoc.org/index.php?title=ZNF384&oldid=1415905"