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{{Infobox_gene}}
{{Infobox_gene}}


'''Zinc finger and BTB domain-containing protein 32''' is encoded by the '''ZBTB32''' [[gene]]. The protein is a transcriptional [[repressor]] and the gene is expressed in [[T cell|T]] and [[B cell]]s upon activation, but also significantly in testis cells. It is a member of the '''Po'''xviruses and Zinc-finger (POZ) and '''K'''rüppel (POK) family of proteins,<ref name="pmid10572087">{{cite journal | vauthors = Hoatlin ME, Zhi Y, Ball H, Silvey K, Melnick A, Stone S, Arai S, Hawe N, Owen G, Zelent A, Licht JD | title = A novel BTB/POZ transcriptional repressor protein interacts with the Fanconi anemia group C protein and PLZF | journal = Blood | volume = 94 | issue = 11 | pages = 3737–47 | date = December 1999 | pmid = 10572087 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ZBTB32 zinc finger and BTB domain containing 32| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27033 }}</ref> and was identified in multiple screens involving either immune cell tumorigenesis or immune cell development.
'''Zinc finger and BTB domain-containing protein 32''' is a [[protein]] that in humans is encoded by the 1960 bp '''ZBTB32''' [[gene]]. The 52 kDa protein (487 aa) is a transcriptional [[repressor]] and the gene is expressed in [[T cell|T]] and [[B cell]]s upon activation, but also significantly in testis cells. It is a member of the '''Po'''xviruses and Zinc-finger (POZ) and '''K'''rüppel (POK) family of proteins,<ref name="pmid10572087">{{cite journal | vauthors = Hoatlin ME, Zhi Y, Ball H, Silvey K, Melnick A, Stone S, Arai S, Hawe N, Owen G, Zelent A, Licht JD | title = A novel BTB/POZ transcriptional repressor protein interacts with the Fanconi anemia group C protein and PLZF | journal = Blood | volume = 94 | issue = 11 | pages = 3737–47 | date = December 1999 | pmid = 10572087 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ZBTB32 zinc finger and BTB domain containing 32| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27033 }}</ref> and was identified in multiple screens involving either immune cell tumorigenesis or immune cell development.


The protein recruits histone modification enzymes to chromatin to affect gene activation.<ref name="Yoon_2012" /> ZBTB32 recruits corepressors, such as [[N-CoR]] and [[HDAC]]s to its target genes, induces repressive chromatin states and acts cooperatively with other proteins, e.g. with [[PRDM1 |Blimp-1]],<ref name="Yoon_2012" /> to suppress the transcription of genes .<ref name="Yoon_2012">{{cite journal | vauthors = Yoon HS, Scharer CD, Majumder P, Davis CW, Butler R, Zinzow-Kramer W, Skountzou I, Koutsonanos DG, Ahmed R, Boss JM | title = ZBTB32 is an early repressor of the CIITA and MHC class II gene expression during B cell differentiation to plasma cells | journal = Journal of Immunology | volume = 189 | issue = 5 | pages = 2393–403 | year = 2012 | pmid = 22851713 | pmc = 3424359 | doi = 10.4049/jimmunol.1103371 }}</ref>
The protein recruits histone modification enzymes to chromatin to affect gene activation.<ref name="Yoon_2012" /> ZBTB32 recruits corepressors, such as [[N-CoR]] and [[HDAC]]s to its target genes, induces repressive chromatin states and acts cooperatively with other proteins, e.g. with [[PRDM1|Blimp-1]],<ref name="Yoon_2012" /> to suppress the transcription of genes .<ref name="Yoon_2012">{{cite journal | vauthors = Yoon HS, Scharer CD, Majumder P, Davis CW, Butler R, Zinzow-Kramer W, Skountzou I, Koutsonanos DG, Ahmed R, Boss JM | title = ZBTB32 is an early repressor of the CIITA and MHC class II gene expression during B cell differentiation to plasma cells | journal = Journal of Immunology | volume = 189 | issue = 5 | pages = 2393–403 | year = 2012 | pmid = 22851713 | pmc = 3424359 | doi = 10.4049/jimmunol.1103371 }}</ref>


It contains a N-terminal [[BTB/POZ domain]] (IPR000210) or a SKP1/BTB/POZ domain (IPR011333), and three C-terminal [[zinc finger]]s, Znf_C2H2_sf. (IPR036236),  Znf_C2H2_type domain (IPR013087), a Znf_RING/FYVE/PHD domain (IPR013083), followed by a putative Znf_UBZ3 domain (REF).   
It contains a N-terminal [[BTB/POZ domain]] (IPR000210) or a SKP1/BTB/POZ domain (IPR011333), and three C-terminal [[zinc finger]]s, Znf_C2H2_sf. (IPR036236),  Znf_C2H2_type domain (IPR013087), a Znf_RING/FYVE/PHD domain (IPR013083), followed by a putative UBZ4 domain.<ref name="pmid25162118">{{cite journal | vauthors = Rizzo AA, Salerno PE, Bezsonova I, Korzhnev DM | title = NMR structure of the human Rad18 zinc finger in complex with ubiquitin defines a class of UBZ domains in proteins linked to the DNA damage response | journal = Biochemistry | volume = 53 | issue = 37 | pages = 5895–906 | date = September 2014 | pmid = 25162118 }}</ref>


== Aliases for Zinc Finger and BTB Domain Containing 32 (ZBTB32) protein ==
== Nomenclature ==
Zinc finger and BTB domain-containing protein 32 is also known as:
* Fanconi Anemia Zinc Finger Protein (FAZF),
* Testis Zinc Finger Protein (TZFP),
* FANCC-Interacting Protein (FAXP),
* Zinc Finger Protein 538 (ZNF538),
* Repressor of GATA3 (ROG),
* PLZF (Promyelocytic Leukemia Zinc Finger and Zbtb16)-like zinc finger protein (PLZP)


Fanconi Anemia Zinc Finger Protein (FAZF),
== Interactions ==
Testis Zinc Finger Protein (TZFP),
FANCC-Interacting Protein (FAXP),
Zinc Finger Protein 538 (ZNF538),
Repressor of GATA3 (ROG)


== Interactions ==
Zbtb32 has been shown to [[Protein–protein interaction|interact]] with:
* Fanconi anemia complementation group C (Fancc)<ref name = autogenerated1>{{cite journal | vauthors = Hoatlin ME, Zhi Y, Ball H, Silvey K, Melnick A, Stone S, Arai S, Hawe N, Owen G, Zelent A, Licht JD | title = A novel BTB/POZ transcriptional repressor protein interacts with the Fanconi anemia group C protein and PLZF | journal = Blood | volume = 94 | issue = 11 | pages = 3737–47 | date = December 1999 | pmid = 10572087 | doi =  }}</ref><ref name = pmid14499622>{{cite journal | vauthors = Reuter TY, Medhurst AL, Waisfisz Q, Zhi Y, Herterich S, Hoehn H, Gross HJ, Joenje H, Hoatlin ME, Mathew CG, Huber PA | title = Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport | journal = Experimental Cell Research | volume = 289 | issue = 2 | pages = 211–21 | date = October 2003 | pmid = 14499622 | doi =  10.1016/s0014-4827(03)00261-1}}</ref>
* Thioredoxin interacting protein (Txnip), but the interaction might be unspecific; however, Vitamin D3 upregulated protein 1 (VDUP1) seems to interact,<ref name = pmid12821938>{{cite journal | vauthors = Han SH, Jeon JH, Ju HR, Jung U, Kim KY, Yoo HS, Lee YH, Song KS, Hwang HM, Na YS, Yang Y, Lee KN, Choi I | title = VDUP1 upregulated by TGF-beta1 and 1,25-dihydorxyvitamin D3 inhibits tumor cell growth by blocking cell-cycle progression | journal = Oncogene | volume = 22 | issue = 26 | pages = 4035–46 | date = June 2003 | pmid = 12821938 | doi = 10.1038/sj.onc.1206610 }}</ref> and
* Zinc finger and BTB domain-containing protein 16 (Zbtb16)<ref name = pmid10572087/>
* Zinc-finger elbow-related proline domain protein 2 (Zpo2).<ref name="pmid28258171">{{cite journal | vauthors = Shahi P, Wang CY, Lawson DA, Slorach EM, Lu A, Yu Y, Lai MD, Gonzalez Velozo H, Werb Z | title = ZNF503/Zpo2 drives aggressive breast cancer progression by down-regulation of GATA3 expression | journal = Proc Natl Acad Sci U S A | volume = 114 | issue = 12 | pages = 3169–3174 | date = 2017 | pmid =  28258171 | doi = 10.1073/pnas.1701690114 }}</ref>
* GATA binding protein (Gata2)<ref name = pmid11964310>{{cite journal | vauthors = Tsuzuki S, Enver T | title = Interactions of GATA-2 with the promyelocytic leukemia zinc finger (PLZF) protein, its homologue FAZF, and the t(11;17)-generated PLZF-retinoic acid receptor alpha oncoprotein | journal = Blood | volume = 99 | issue = 9 | pages = 3404–10 | date = May 2002 | pmid = 11964310 | doi = 10.1182/blood.V99.9.3404 }}</ref>
 
== Immune system ==
 
The expression of ZBTB32 is induced by [[inflammatory cytokine]]s and promotes proliferation of [[natural killer]] cells.<ref name="pmid26324348">{{cite journal | vauthors = Beaulieu AM, Madera S, Sun JC | title = Molecular Programming of Immunological Memory in Natural Killer Cells | journal = Advances in Experimental Medicine and Biology | volume = 850 | issue = | pages = 81–91 | date = 2015 | pmid = 26324348 | doi = 10.1007/978-3-319-15774-0_7 | url = }}</ref>
 
Zbtb32 [[knockout mice]] show a trend to develop [[type 1 diabetes]], although the difference is not statistically different.  Furthermore the Zbtb32 do not show a difference in [[lymphocyte]] proliferation, possibly due to compensation from other genes.<ref name="pmid29707204">{{cite journal | vauthors = Coley WD, Zhao Y, Benck CJ, Liu Y, Hotta-Iwamura C, Rahman MJ, Tarbell KV | title = Loss of Zbtb32 in NOD mice does not significantly alter T cell responses | journal = F1000Research | volume = 7 | issue = | pages = 318 | date = 2018 | pmid = 29707204 | pmc = 5909056 | doi = 10.12688/f1000research.13864.1 }}</ref>
 
== Cancer ==
 
ZBTB32 is highly expressed spermatogonial stem cells, in hematopoietic stem and progenitor cells (please also refer to the RNA expression pattern to the right),  in [[diffuse large B-cell lymphoma]] (DLBCL) and appears to suppress the immune system by silencing the [[CIITA]] gene.<ref name="Zhu">{{cite journal | vauthors = Zhu C, Chen G, Zhao Y, Gao XM, Wang J | title = Regulation of the Development and Function of B Cells by ZBTB Transcription Factors | journal = Frontiers in Immunology | volume = 9 | issue = | pages = 580 | date = 2018 | pmid = 29616049 | pmc = 5869932 | doi = 10.3389/fimmu.2018.00580 }}</ref>


ZBTB32 has been shown to [[Protein–protein interaction|interact]] with:
The transcription factor gene ''GATA3'' is altered in mammary tumors. Down-regulation of ''GATA3'' expression and activity by the Zinc-finger elbow-related proline domain protein 2 (Zpo2), whereas Zbtb32 facilitates Zpo2 targeting to the ''GATA3'' promoter, results in the development of aggressive breast cancers.<ref name="pmid28258171"/>
* [[Fanconi anemia complementation group C (FANCC)]],<ref name = autogenerated1>{{cite journal | vauthors = Hoatlin ME, Zhi Y, Ball H, Silvey K, Melnick A, Stone S, Arai S, Hawe N, Owen G, Zelent A, Licht JD | title = A novel BTB/POZ transcriptional repressor protein interacts with the Fanconi anemia group C protein and PLZF | journal = Blood | volume = 94 | issue = 11 | pages = 3737–47 | date = December 1999 | pmid = 10572087 | doi =  }}</ref><ref name = pmid14499622>{{cite journal | vauthors = Reuter TY, Medhurst AL, Waisfisz Q, Zhi Y, Herterich S, Hoehn H, Gross HJ, Joenje H, Hoatlin ME, Mathew CG, Huber PA | title = Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport | journal = Experimental Cell Research | volume = 289 | issue = 2 | pages = 211–21 | date = October 2003 | pmid = 14499622 | doi =  10.1016/s0014-4827(03)00261-1}}</ref>
* [[Thioredoxin interacting protein (TXNIP), CAVE interaction unspecific ? Vitamin D3 upregulated protein 1 (VDUP1) does interact, see REF]],<ref name = pmid12821938>{{cite journal | vauthors = Han SH, Jeon JH, Ju HR, Jung U, Kim KY, Yoo HS, Lee YH, Song KS, Hwang HM, Na YS, Yang Y, Lee KN, Choi I | title = VDUP1 upregulated by TGF-beta1 and 1,25-dihydorxyvitamin D3 inhibits tumor cell growth by blocking cell-cycle progression | journal = Oncogene | volume = 22 | issue = 26 | pages = 4035–46 | date = June 2003 | pmid = 12821938 | doi = 10.1038/sj.onc.1206610 }}</ref> and
* [[Zinc finger and BTB domain-containing protein 16 (ZBTB16)]].<ref name = pmid10572087/>


== ZBTB32 in DNA Repair ==
A DNA methylation correlation network was built based on the methylation correlation between differentially methylated genes. A survival analysis of candidate biomarkers was performed. One of eight biomarkers and hub genes identified
in colon cancer is ''ZBTB32''.<ref name="pmid25774687">{{cite journal | vauthors = Zhang C, Zhao H, Li J, Liu H, Wang F, Wei Y, Su J, Zhang D, Liu T, Zhang Y | title = The identification of specific methylation patterns across different cancers | journal = PLoS One | volume = 10| issue = 3 | pages = e0120361 | date = 2015 | pmid = 25774687 | doi = 10.1371/journal.pone.0120361}}</ref>


Judged by the ability of ZBTB32 to regulate epigenetic modifications, it is reasonable to postulate the protein affects DNA damage signaling and DNA repair. In humans, histone methylation has been shown to regulate DNA mismatch repair (REF). The physical interaction of the proliferating cell nuclear antigen (PCNA) sliding clamp with the MutLα (PMS2-MLH1) endonuclease is required for mismatch repair activation (REF.) The enzyme and pathway database Reactome (REF and link) assigns to ZBTB32 a role in the recognition of DNA damage by the PCNA-containing replication complex (link R-HSA-110314; but please be aware: UAF1 is not ZBTB32 as confirmed by the database curators recently and the error is/was associated with a reference sequence update. Changes expected to be visible in the database in Dec 2017/Jan 2018) and Fanconi Anemia pathway (link R-HSA-6783310). A putative ZBTB32 RING-UBZ3 (RING-'''U'''biquitin-'''b'''inding '''z'''inc finger domain '''3'''; ZBTB32 zf 2 and 3) domain might interact with Ubiquitin (Ub) as other UBZ containing proteins do with Ub-PCNA (REF).
The expression of Zbtb32 is upregulated after exposure to [[cisplatin]].<ref name="Sourisseau_2016">{{cite journal | vauthors = Sourisseau T, Helissey C, Lefebvre C, Ponsonnailles F, Malka-Mahieu H, Olaussen KA, André F, Vagner S, Soria JC | title = Translational regulation of the mRNA encoding the ubiquitin peptidase USP1 involved in the DNA damage response as a determinant of Cisplatin resistance | journal = Cell Cycle | volume = 15 | issue = 2 | pages = 295–302 | date = 2016 | pmid = 26825230 | pmc = 4825832 | doi = 10.1080/15384101.2015.1120918 }}</ref>
{{clear}}
Fanconi Anemia


== References ==
== References ==
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{{refbegin | 2}}
{{refbegin | 2}}
* {{cite journal | vauthors = Lin W, Lai CH, Tang CJ, Huang CJ, Tang TK | title = Identification and gene structure of a novel human PLZF-related transcription factor gene, TZFP | journal = Biochemical and Biophysical Research Communications | volume = 264 | issue = 3 | pages = 789–95 | date = November 1999 | pmid = 10544010 | doi = 10.1006/bbrc.1999.1594 }}
* {{cite journal | vauthors = Lin W, Lai CH, Tang CJ, Huang CJ, Tang TK | title = Identification and gene structure of a novel human PLZF-related transcription factor gene, TZFP | journal = Biochemical and Biophysical Research Communications | volume = 264 | issue = 3 | pages = 789–95 | date = November 1999 | pmid = 10544010 | doi = 10.1006/bbrc.1999.1594 }}
* {{cite journal | vauthors = Tsuzuki S, Enver T | title = Interactions of GATA-2 with the promyelocytic leukemia zinc finger (PLZF) protein, its homologue FAZF, and the t(11;17)-generated PLZF-retinoic acid receptor alpha oncoprotein | journal = Blood | volume = 99 | issue = 9 | pages = 3404–10 | date = May 2002 | pmid = 11964310 | doi = 10.1182/blood.V99.9.3404 }}
* {{cite journal | vauthors = Dai MS, Chevallier N, Stone S, Heinrich MC, McConnell M, Reuter T, Broxmeyer HE, Licht JD, Lu L, Hoatlin ME | title = The effects of the Fanconi anemia zinc finger (FAZF) on cell cycle, apoptosis, and proliferation are differentiation stage-specific | journal = The Journal of Biological Chemistry | volume = 277 | issue = 29 | pages = 26327–34 | date = July 2002 | pmid = 11986317 | doi = 10.1074/jbc.M201834200 }}
* {{cite journal | vauthors = Dai MS, Chevallier N, Stone S, Heinrich MC, McConnell M, Reuter T, Broxmeyer HE, Licht JD, Lu L, Hoatlin ME | title = The effects of the Fanconi anemia zinc finger (FAZF) on cell cycle, apoptosis, and proliferation are differentiation stage-specific | journal = The Journal of Biological Chemistry | volume = 277 | issue = 29 | pages = 26327–34 | date = July 2002 | pmid = 11986317 | doi = 10.1074/jbc.M201834200 }}
* {{cite journal | vauthors = Han SH, Jeon JH, Ju HR, Jung U, Kim KY, Yoo HS, Lee YH, Song KS, Hwang HM, Na YS, Yang Y, Lee KN, Choi I | title = VDUP1 upregulated by TGF-beta1 and 1,25-dihydorxyvitamin D3 inhibits tumor cell growth by blocking cell-cycle progression | journal = Oncogene | volume = 22 | issue = 26 | pages = 4035–46 | date = June 2003 | pmid = 12821938 | doi = 10.1038/sj.onc.1206610 }}
* {{cite journal | vauthors = Han SH, Jeon JH, Ju HR, Jung U, Kim KY, Yoo HS, Lee YH, Song KS, Hwang HM, Na YS, Yang Y, Lee KN, Choi I | title = VDUP1 upregulated by TGF-beta1 and 1,25-dihydorxyvitamin D3 inhibits tumor cell growth by blocking cell-cycle progression | journal = Oncogene | volume = 22 | issue = 26 | pages = 4035–46 | date = June 2003 | pmid = 12821938 | doi = 10.1038/sj.onc.1206610 }}
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[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{gene-19-stub}}

Latest revision as of 14:13, 11 October 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Zinc finger and BTB domain-containing protein 32 is a protein that in humans is encoded by the 1960 bp ZBTB32 gene. The 52 kDa protein (487 aa) is a transcriptional repressor and the gene is expressed in T and B cells upon activation, but also significantly in testis cells. It is a member of the Poxviruses and Zinc-finger (POZ) and Krüppel (POK) family of proteins,[1][2] and was identified in multiple screens involving either immune cell tumorigenesis or immune cell development.

The protein recruits histone modification enzymes to chromatin to affect gene activation.[3] ZBTB32 recruits corepressors, such as N-CoR and HDACs to its target genes, induces repressive chromatin states and acts cooperatively with other proteins, e.g. with Blimp-1,[3] to suppress the transcription of genes .[3]

It contains a N-terminal BTB/POZ domain (IPR000210) or a SKP1/BTB/POZ domain (IPR011333), and three C-terminal zinc fingers, Znf_C2H2_sf. (IPR036236), Znf_C2H2_type domain (IPR013087), a Znf_RING/FYVE/PHD domain (IPR013083), followed by a putative UBZ4 domain.[4]

Nomenclature

Zinc finger and BTB domain-containing protein 32 is also known as:

  • Fanconi Anemia Zinc Finger Protein (FAZF),
  • Testis Zinc Finger Protein (TZFP),
  • FANCC-Interacting Protein (FAXP),
  • Zinc Finger Protein 538 (ZNF538),
  • Repressor of GATA3 (ROG),
  • PLZF (Promyelocytic Leukemia Zinc Finger and Zbtb16)-like zinc finger protein (PLZP)

Interactions

Zbtb32 has been shown to interact with:

  • Fanconi anemia complementation group C (Fancc)[5][6]
  • Thioredoxin interacting protein (Txnip), but the interaction might be unspecific; however, Vitamin D3 upregulated protein 1 (VDUP1) seems to interact,[7] and
  • Zinc finger and BTB domain-containing protein 16 (Zbtb16)[1]
  • Zinc-finger elbow-related proline domain protein 2 (Zpo2).[8]
  • GATA binding protein (Gata2)[9]

Immune system

The expression of ZBTB32 is induced by inflammatory cytokines and promotes proliferation of natural killer cells.[10]

Zbtb32 knockout mice show a trend to develop type 1 diabetes, although the difference is not statistically different. Furthermore the Zbtb32 do not show a difference in lymphocyte proliferation, possibly due to compensation from other genes.[11]

Cancer

ZBTB32 is highly expressed spermatogonial stem cells, in hematopoietic stem and progenitor cells (please also refer to the RNA expression pattern to the right), in diffuse large B-cell lymphoma (DLBCL) and appears to suppress the immune system by silencing the CIITA gene.[12]

The transcription factor gene GATA3 is altered in mammary tumors. Down-regulation of GATA3 expression and activity by the Zinc-finger elbow-related proline domain protein 2 (Zpo2), whereas Zbtb32 facilitates Zpo2 targeting to the GATA3 promoter, results in the development of aggressive breast cancers.[8]

A DNA methylation correlation network was built based on the methylation correlation between differentially methylated genes. A survival analysis of candidate biomarkers was performed. One of eight biomarkers and hub genes identified in colon cancer is ZBTB32.[13]

The expression of Zbtb32 is upregulated after exposure to cisplatin.[14]

References

  1. ↑ 1.0 1.1 Hoatlin ME, Zhi Y, Ball H, Silvey K, Melnick A, Stone S, Arai S, Hawe N, Owen G, Zelent A, Licht JD (December 1999). "A novel BTB/POZ transcriptional repressor protein interacts with the Fanconi anemia group C protein and PLZF". Blood. 94 (11): 3737–47. PMID 10572087.
  2. ↑ "Entrez Gene: ZBTB32 zinc finger and BTB domain containing 32".
  3. ↑ 3.0 3.1 3.2 Yoon HS, Scharer CD, Majumder P, Davis CW, Butler R, Zinzow-Kramer W, Skountzou I, Koutsonanos DG, Ahmed R, Boss JM (2012). "ZBTB32 is an early repressor of the CIITA and MHC class II gene expression during B cell differentiation to plasma cells". Journal of Immunology. 189 (5): 2393–403. doi:10.4049/jimmunol.1103371. PMC 3424359. PMID 22851713.
  4. ↑ Rizzo AA, Salerno PE, Bezsonova I, Korzhnev DM (September 2014). "NMR structure of the human Rad18 zinc finger in complex with ubiquitin defines a class of UBZ domains in proteins linked to the DNA damage response". Biochemistry. 53 (37): 5895–906. PMID 25162118.
  5. ↑ Hoatlin ME, Zhi Y, Ball H, Silvey K, Melnick A, Stone S, Arai S, Hawe N, Owen G, Zelent A, Licht JD (December 1999). "A novel BTB/POZ transcriptional repressor protein interacts with the Fanconi anemia group C protein and PLZF". Blood. 94 (11): 3737–47. PMID 10572087.
  6. ↑ Reuter TY, Medhurst AL, Waisfisz Q, Zhi Y, Herterich S, Hoehn H, Gross HJ, Joenje H, Hoatlin ME, Mathew CG, Huber PA (October 2003). "Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport". Experimental Cell Research. 289 (2): 211–21. doi:10.1016/s0014-4827(03)00261-1. PMID 14499622.
  7. ↑ Han SH, Jeon JH, Ju HR, Jung U, Kim KY, Yoo HS, Lee YH, Song KS, Hwang HM, Na YS, Yang Y, Lee KN, Choi I (June 2003). "VDUP1 upregulated by TGF-beta1 and 1,25-dihydorxyvitamin D3 inhibits tumor cell growth by blocking cell-cycle progression". Oncogene. 22 (26): 4035–46. doi:10.1038/sj.onc.1206610. PMID 12821938.
  8. ↑ 8.0 8.1 Shahi P, Wang CY, Lawson DA, Slorach EM, Lu A, Yu Y, Lai MD, Gonzalez Velozo H, Werb Z (2017). "ZNF503/Zpo2 drives aggressive breast cancer progression by down-regulation of GATA3 expression". Proc Natl Acad Sci U S A. 114 (12): 3169–3174. doi:10.1073/pnas.1701690114. PMID 28258171.
  9. ↑ Tsuzuki S, Enver T (May 2002). "Interactions of GATA-2 with the promyelocytic leukemia zinc finger (PLZF) protein, its homologue FAZF, and the t(11;17)-generated PLZF-retinoic acid receptor alpha oncoprotein". Blood. 99 (9): 3404–10. doi:10.1182/blood.V99.9.3404. PMID 11964310.
  10. ↑ Beaulieu AM, Madera S, Sun JC (2015). "Molecular Programming of Immunological Memory in Natural Killer Cells". Advances in Experimental Medicine and Biology. 850: 81–91. doi:10.1007/978-3-319-15774-0_7. PMID 26324348.
  11. ↑ Coley WD, Zhao Y, Benck CJ, Liu Y, Hotta-Iwamura C, Rahman MJ, Tarbell KV (2018). "Loss of Zbtb32 in NOD mice does not significantly alter T cell responses". F1000Research. 7: 318. doi:10.12688/f1000research.13864.1. PMC 5909056. PMID 29707204.
  12. ↑ Zhu C, Chen G, Zhao Y, Gao XM, Wang J (2018). "Regulation of the Development and Function of B Cells by ZBTB Transcription Factors". Frontiers in Immunology. 9: 580. doi:10.3389/fimmu.2018.00580. PMC 5869932. PMID 29616049.
  13. ↑ Zhang C, Zhao H, Li J, Liu H, Wang F, Wei Y, Su J, Zhang D, Liu T, Zhang Y (2015). "The identification of specific methylation patterns across different cancers". PLoS One. 10 (3): e0120361. doi:10.1371/journal.pone.0120361. PMID 25774687.
  14. ↑ Sourisseau T, Helissey C, Lefebvre C, Ponsonnailles F, Malka-Mahieu H, Olaussen KA, André F, Vagner S, Soria JC (2016). "Translational regulation of the mRNA encoding the ubiquitin peptidase USP1 involved in the DNA damage response as a determinant of Cisplatin resistance". Cell Cycle. 15 (2): 295–302. doi:10.1080/15384101.2015.1120918. PMC 4825832. PMID 26825230.

Further reading

  • Lin W, Lai CH, Tang CJ, Huang CJ, Tang TK (November 1999). "Identification and gene structure of a novel human PLZF-related transcription factor gene, TZFP". Biochemical and Biophysical Research Communications. 264 (3): 789–95. doi:10.1006/bbrc.1999.1594. PMID 10544010.
  • Dai MS, Chevallier N, Stone S, Heinrich MC, McConnell M, Reuter T, Broxmeyer HE, Licht JD, Lu L, Hoatlin ME (July 2002). "The effects of the Fanconi anemia zinc finger (FAZF) on cell cycle, apoptosis, and proliferation are differentiation stage-specific". The Journal of Biological Chemistry. 277 (29): 26327–34. doi:10.1074/jbc.M201834200. PMID 11986317.
  • Han SH, Jeon JH, Ju HR, Jung U, Kim KY, Yoo HS, Lee YH, Song KS, Hwang HM, Na YS, Yang Y, Lee KN, Choi I (June 2003). "VDUP1 upregulated by TGF-beta1 and 1,25-dihydorxyvitamin D3 inhibits tumor cell growth by blocking cell-cycle progression". Oncogene. 22 (26): 4035–46. doi:10.1038/sj.onc.1206610. PMID 12821938.
  • Reuter TY, Medhurst AL, Waisfisz Q, Zhi Y, Herterich S, Hoehn H, Gross HJ, Joenje H, Hoatlin ME, Mathew CG, Huber PA (October 2003). "Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport". Experimental Cell Research. 289 (2): 211–21. doi:10.1016/S0014-4827(03)00261-1. PMID 14499622.
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