YY1

YY1 transcription factor
File:PBB Protein YY1 image.jpg PDB rendering based on 1ubd.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1ubd​
Identifiers
Symbols	YY1 ; DELTA; NF-E1; UCRBP; YIN-YANG-1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 2556
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE YY1 201901 s at tn.png
File:PBB GE YY1 201902 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

YY1 transcription factor, also known as YY1, is a human gene.

YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. YY1 may direct histone deacetylases and histone acetyltransferases to a promoter in order to activate or repress the promoter, thus implicating histone modification in the function of YY1.

Further reading

• Thomas MJ, Seto E (1999). "Unlocking the mechanisms of transcription factor YY1: are chromatin modifying enzymes the key?". Gene. 236 (2): 197–208. PMID 10452940.
• Shi Y, Seto E, Chang LS, Shenk T (1991). "Transcriptional repression by YY1, a human GLI-Krüppel-related protein, and relief of repression by adenovirus E1A protein". Cell. 67 (2): 377–88. PMID 1655281.CS1 maint: Multiple names: authors list (link)
• Park K, Atchison ML (1991). "Isolation of a candidate repressor/activator, NF-E1 (YY-1, delta), that binds to the immunoglobulin kappa 3' enhancer and the immunoglobulin heavy-chain mu E1 site". Proc. Natl. Acad. Sci. U.S.A. 88 (21): 9804–8. PMID 1946405.
• Yang WM, Inouye CJ, Seto E (1995). "Cyclophilin A and FKBP12 interact with YY1 and alter its transcriptional activity". J. Biol. Chem. 270 (25): 15187–93. PMID 7541038.CS1 maint: Multiple names: authors list (link)
• Lee JS, Galvin KM, See RH; et al. (1995). "Relief of YY1 transcriptional repression by adenovirus E1A is mediated by E1A-associated protein p300". Genes Dev. 9 (10): 1188–98. PMID 7758944.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhou Q, Gedrich RW, Engel DA (1995). "Transcriptional repression of the c-fos gene by YY1 is mediated by a direct interaction with ATF/CREB". J. Virol. 69 (7): 4323–30. PMID 7769693.CS1 maint: Multiple names: authors list (link)
• Zhu W, Lossie AC, Camper SA, Gumucio DL (1994). "Chromosomal localization of the transcription factor YY1 in the mouse and human". Mamm. Genome. 5 (4): 234–6. PMID 7912122.CS1 maint: Multiple names: authors list (link)
• Shrivastava A, Saleque S, Kalpana GV; et al. (1994). "Inhibition of transcriptional regulator Yin-Yang-1 by association with c-Myc". Science. 262 (5141): 1889–92. PMID 8266081.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Becker KG, Swergold GD, Ozato K, Thayer RE (1994). "Binding of the ubiquitous nuclear transcription factor YY1 to a cis regulatory sequence in the human LINE-1 transposable element". Hum. Mol. Genet. 2 (10): 1697–702. PMID 8268924.CS1 maint: Multiple names: authors list (link)
• Margolis DM, Somasundaran M, Green MR (1994). "Human transcription factor YY1 represses human immunodeficiency virus type 1 transcription and virion production". J. Virol. 68 (2): 905–10. PMID 8289393.CS1 maint: Multiple names: authors list (link)
• Lee JS, Galvin KM, Shi Y (1993). "Evidence for physical interaction between the zinc-finger transcription factors YY1 and Sp1". Proc. Natl. Acad. Sci. U.S.A. 90 (13): 6145–9. PMID 8327494.CS1 maint: Multiple names: authors list (link)
• Yang WM, Inouye C, Zeng Y; et al. (1996). "Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3". Proc. Natl. Acad. Sci. U.S.A. 93 (23): 12845–50. PMID 8917507.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Houbaviy HB, Usheva A, Shenk T, Burley SK (1997). "Cocrystal structure of YY1 bound to the adeno-associated virus P5 initiator". Proc. Natl. Acad. Sci. U.S.A. 93 (24): 13577–82. PMID 8942976.CS1 maint: Multiple names: authors list (link)
• Kalenik JL, Chen D, Bradley ME; et al. (1997). "Yeast two-hybrid cloning of a novel zinc finger protein that interacts with the multifunctional transcription factor YY1". Nucleic Acids Res. 25 (4): 843–9. PMID 9016636.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cole EG, Gaston K (1997). "A functional YY1 binding site is necessary and sufficient to activate Surf-1 promoter activity in response to serum growth factors". Nucleic Acids Res. 25 (18): 3705–11. PMID 9278494.
• Yang WM, Yao YL, Sun JM; et al. (1997). "Isolation and characterization of cDNAs corresponding to an additional member of the human histone deacetylase gene family". J. Biol. Chem. 272 (44): 28001–7. PMID 9346952.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Romerio F, Gabriel MN, Margolis DM (1997). "Repression of human immunodeficiency virus type 1 through the novel cooperation of human factors YY1 and LSF". J. Virol. 71 (12): 9375–82. PMID 9371597.CS1 maint: Multiple names: authors list (link)
• McNeil S, Guo B, Stein JL; et al. (1998). "Targeting of the YY1 transcription factor to the nucleolus and the nuclear matrix in situ: the C-terminus is a principal determinant for nuclear trafficking". J. Cell. Biochem. 68 (4): 500–10. PMID 9493912.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Viles JH, Patel SU, Mitchell JB; et al. (1998). "Design, synthesis and structure of a zinc finger with an artificial beta-turn". J. Mol. Biol. 279 (4): 973–86. doi:10.1006/jmbi.1998.1764. PMID 9642075.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yao YL, Dupont BR, Ghosh S; et al. (1998). "Cloning, chromosomal localization and promoter analysis of the human transcription factor YY1". Nucleic Acids Res. 26 (16): 3776–83. PMID 9685495.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)