Testicular receptor 2: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
The '''testicular receptor 2''' ('''TR2''') also known as '''NR2C1''' (nuclear receptor subfamily 2, group C, member 1) is [[protein]] that in humans is encoded by the ''NR2C1'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NR2C1 nuclear receptor subfamily 2, group C, member 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7181| accessdate = }}</ref><ref name="pmid2597158">{{cite journal | vauthors = Chang C, Kokontis J, Acakpo-Satchivi L, Liao S, Takeda H, Chang Y | title = Molecular cloning of new human TR2 receptors: a class of steroid receptor with multiple ligand-binding domains | journal = Biochemical and Biophysical Research Communications | volume = 165 | issue = 2 | pages = 735–41 | date = Dec 1989 | pmid = 2597158 | doi = 10.1016/S0006-291X(89)80028-2 }}</ref> TR2 is a member of the [[nuclear receptor]] family of [[transcription factor]]s.
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = Nuclear receptor subfamily 2, group C, member 1
| HGNCid = 7971
| Symbol = NR2C1
| AltSymbols =; TR2; TR2-11
| OMIM = 601529
| ECnumber = 
| Homologene = 55731
| MGIid = 1352465
| GeneAtlas_image1 = PBB_GE_NR2C1_210530_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_NR2C1_210531_at_tn.png
| GeneAtlas_image3 = PBB_GE_NR2C1_204791_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003707 |text = steroid hormone receptor activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7181
    | Hs_Ensembl = ENSG00000120798
    | Hs_RefseqProtein = NP_001027458
    | Hs_RefseqmRNA = NM_001032287
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 12
    | Hs_GenLoc_start = 93939802
    | Hs_GenLoc_end = 93991444
    | Hs_Uniprot = P13056
    | Mm_EntrezGene = 22025
    | Mm_Ensembl = ENSMUSG00000005897
    | Mm_RefseqmRNA = NM_011629
    | Mm_RefseqProtein = NP_035759
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 10
    | Mm_GenLoc_start = 93577812
    | Mm_GenLoc_end = 93625483
    | Mm_Uniprot = Q0VGP8
  }}
}}


The '''testicular receptor 2''' ('''TR2''') is a member of the [[nuclear receptor]] family of [[transcription factor]]s.  TR2 is encoded by the '''{{gene|NR2C1}}''' gene (nuclear receptor subfamily 2, group C, member 1).<ref name="entrez">{{cite web | title = Entrez Gene: NR2C1 nuclear receptor subfamily 2, group C, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7181| accessdate = }}</ref>
Testicular receptor 2 has been shown to [[Protein-protein_interaction|interact]] with:
* [[Androgen receptor]],<ref name="pmid12949936">{{cite journal | vauthors = Mu X, Chang C | title = TR2 orphan receptor functions as negative modulator for androgen receptor in prostate cancer cells PC-3 | journal = The Prostate | volume = 57 | issue = 2 | pages = 129–33 | date = Oct 2003 | pmid = 12949936 | doi = 10.1002/pros.10282 }}</ref>
*  [[Estrogen receptor alpha]],<ref name="pmid12093804">{{cite journal | vauthors = Hu YC, Shyr CR, Che W, Mu XM, Kim E, Chang C | title = Suppression of estrogen receptor-mediated transcription and cell growth by interaction with TR2 orphan receptor | journal = The Journal of Biological Chemistry | volume = 277 | issue = 37 | pages = 33571–9 | date = Sep 2002 | pmid = 12093804 | doi = 10.1074/jbc.M203531200 }}</ref>
* [[HDAC3]],<ref name="pmid14521922">{{cite journal | vauthors = Li G, Franco PJ, Wei LN | title = Identification of histone deacetylase-3 domains that interact with the orphan nuclear receptor TR2 | journal = Biochemical and Biophysical Research Communications | volume = 310 | issue = 2 | pages = 384–90 | date = Oct 2003 | pmid = 14521922 | doi = 10.1016/j.bbrc.2003.08.145 }}</ref><ref name="pmid12943985">{{cite journal | vauthors = Franco PJ, Li G, Wei LN | title = Interaction of nuclear receptor zinc finger DNA binding domains with histone deacetylase | journal = Molecular and Cellular Endocrinology | volume = 206 | issue = 1-2 | pages = 1–12 | date = Aug 2003 | pmid = 12943985 | doi = 10.1016/S0303-7207(03)00254-5 }}</ref><ref name="pmid11463856">{{cite journal | vauthors = Franco PJ, Farooqui M, Seto E, Wei LN | title = The orphan nuclear receptor TR2 interacts directly with both class I and class II histone deacetylases | journal = Molecular Endocrinology | volume = 15 | issue = 8 | pages = 1318–28 | date = Aug 2001 | pmid = 11463856 | doi = 10.1210/mend.15.8.0682 }}</ref> and
* [[HDAC4]].<ref name=pmid12943985/><ref name=pmid11463856/>  


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== See also ==
{{PBB_Summary
* [[Testicular receptor]]
| section_title =  
| summary_text =  
}}


==See also==
== References ==
* [[Testicular receptor]]
{{reflist}}


==References==
== Further reading ==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Chang C, Kokontis J | title = Identification of a new member of the steroid receptor super-family by cloning and sequence analysis | journal = Biochemical and Biophysical Research Communications | volume = 155 | issue = 2 | pages = 971–7 | date = Sep 1988 | pmid = 3421977 | doi = 10.1016/S0006-291X(88)80591-6 }}
| citations =
* {{cite journal | vauthors = Lin DL, Wu SQ, Chang C | title = The genomic structure and chromosomal location of the human TR2 orphan receptor, a member of the steroid receptor superfamily | journal = Endocrine | volume = 8 | issue = 2 | pages = 123–34 | date = Apr 1998 | pmid = 9704569 | doi = 10.1385/ENDO:8:2:123 }}
*{{cite journal | author=Chang C, Kokontis J, Acakpo-Satchivi L, ''et al.'' |title=Molecular cloning of new human TR2 receptors: a class of steroid receptor with multiple ligand-binding domains. |journal=Biochem. Biophys. Res. Commun. |volume=165 |issue= 2 |pages= 735-41 |year= 1990 |pmid= 2597158 |doi=  }}
* {{cite journal | vauthors = Lee CH, Chinpaisal C, Wei LN | title = A novel nuclear receptor heterodimerization pathway mediated by orphan receptors TR2 and TR4 | journal = The Journal of Biological Chemistry | volume = 273 | issue = 39 | pages = 25209–15 | date = Sep 1998 | pmid = 9737983 | doi = 10.1074/jbc.273.39.25209 }}
*{{cite journal  | author=Chang C, Kokontis J |title=Identification of a new member of the steroid receptor super-family by cloning and sequence analysis. |journal=Biochem. Biophys. Res. Commun. |volume=155 |issue= 2 |pages= 971-7 |year= 1988 |pmid= 3421977 |doi= }}
* {{cite journal | vauthors = Lee CH, Chinpaisal C, Wei LN | title = Cloning and characterization of mouse RIP140, a corepressor for nuclear orphan receptor TR2 | journal = Molecular and Cellular Biology | volume = 18 | issue = 11 | pages = 6745–55 | date = Nov 1998 | pmid = 9774688 | pmc = 109258 | doi =  10.1128/mcb.18.11.6745}}
*{{cite journal | author=Lin DL, Wu SQ, Chang C |title=The genomic structure and chromosomal location of the human TR2 orphan receptor, a member of the steroid receptor superfamily. |journal=Endocrine |volume=8 |issue= 2 |pages= 123-34 |year= 1998 |pmid= 9704569 |doi= }}
* {{cite journal | vauthors = Yu Z, Lee CH, Chinpaisal C, Wei LN | title = A constitutive nuclear localization signal from the second zinc-finger of orphan nuclear receptor TR2 | journal = The Journal of Endocrinology | volume = 159 | issue = 1 | pages = 53–60 | date = Oct 1998 | pmid = 9795341 | doi = 10.1677/joe.0.1590053 }}
*{{cite journal | author=Lee CH, Chinpaisal C, Wei LN |title=A novel nuclear receptor heterodimerization pathway mediated by orphan receptors TR2 and TR4. |journal=J. Biol. Chem. |volume=273 |issue= 39 |pages= 25209-15 |year= 1998 |pmid= 9737983 |doi= }}
* {{cite journal | vauthors = Franco PJ, Farooqui M, Seto E, Wei LN | title = The orphan nuclear receptor TR2 interacts directly with both class I and class II histone deacetylases | journal = Molecular Endocrinology | volume = 15 | issue = 8 | pages = 1318–28 | date = Aug 2001 | pmid = 11463856 | doi = 10.1210/mend.15.8.0682 }}
*{{cite journal | author=Lee CH, Chinpaisal C, Wei LN |title=Cloning and characterization of mouse RIP140, a corepressor for nuclear orphan receptor TR2. |journal=Mol. Cell. Biol. |volume=18 |issue= 11 |pages= 6745-55 |year= 1998 |pmid= 9774688 |doi=  }}
* {{cite journal | vauthors = Tanabe O, Katsuoka F, Campbell AD, Song W, Yamamoto M, Tanimoto K, Engel JD | title = An embryonic/fetal beta-type globin gene repressor contains a nuclear receptor TR2/TR4 heterodimer | journal = The EMBO Journal | volume = 21 | issue = 13 | pages = 3434–42 | date = Jul 2002 | pmid = 12093744 | pmc = 126089 | doi = 10.1093/emboj/cdf340 }}
*{{cite journal | author=Yu Z, Lee CH, Chinpaisal C, Wei LN |title=A constitutive nuclear localization signal from the second zinc-finger of orphan nuclear receptor TR2. |journal=J. Endocrinol. |volume=159 |issue= 1 |pages= 53-60 |year= 1999 |pmid= 9795341 |doi= }}
* {{cite journal | vauthors = Hu YC, Shyr CR, Che W, Mu XM, Kim E, Chang C | title = Suppression of estrogen receptor-mediated transcription and cell growth by interaction with TR2 orphan receptor | journal = The Journal of Biological Chemistry | volume = 277 | issue = 37 | pages = 33571–9 | date = Sep 2002 | pmid = 12093804 | doi = 10.1074/jbc.M203531200 }}
*{{cite journal | author=Franco PJ, Farooqui M, Seto E, Wei LN |title=The orphan nuclear receptor TR2 interacts directly with both class I and class II histone deacetylases. |journal=Mol. Endocrinol. |volume=15 |issue= 8 |pages= 1318-28 |year= 2001 |pmid= 11463856 |doi= }}
* {{cite journal | vauthors = Inui S, Lee YF, Chang E, Shyr CR, Chang C | title = Differential and bi-directional regulation between TR2/TR4 orphan nuclear receptors and a specific ligand mediated-peroxisome proliferator-activated receptor alpha in human HaCaT keratinocytes | journal = Journal of Dermatological Science | volume = 31 | issue = 1 | pages = 65–71 | date = Feb 2003 | pmid = 12615366 | doi = 10.1016/S0923-1811(02)00152-4 }}
*{{cite journal | author=Tanabe O, Katsuoka F, Campbell AD, ''et al.'' |title=An embryonic/fetal beta-type globin gene repressor contains a nuclear receptor TR2/TR4 heterodimer. |journal=EMBO J. |volume=21 |issue= 13 |pages= 3434-42 |year= 2002 |pmid= 12093744 |doi= 10.1093/emboj/cdf340 }}
* {{cite journal | vauthors = Franco PJ, Li G, Wei LN | title = Interaction of nuclear receptor zinc finger DNA binding domains with histone deacetylase | journal = Molecular and Cellular Endocrinology | volume = 206 | issue = 1-2 | pages = 1–12 | date = Aug 2003 | pmid = 12943985 | doi = 10.1016/S0303-7207(03)00254-5 }}
*{{cite journal | author=Hu YC, Shyr CR, Che W, ''et al.'' |title=Suppression of estrogen receptor-mediated transcription and cell growth by interaction with TR2 orphan receptor. |journal=J. Biol. Chem. |volume=277 |issue= 37 |pages= 33571-9 |year= 2002 |pmid= 12093804 |doi= 10.1074/jbc.M203531200 }}
* {{cite journal | vauthors = Mu X, Chang C | title = TR2 orphan receptor functions as negative modulator for androgen receptor in prostate cancer cells PC-3 | journal = The Prostate | volume = 57 | issue = 2 | pages = 129–33 | date = Oct 2003 | pmid = 12949936 | doi = 10.1002/pros.10282 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Li G, Franco PJ, Wei LN | title = Identification of histone deacetylase-3 domains that interact with the orphan nuclear receptor TR2 | journal = Biochemical and Biophysical Research Communications | volume = 310 | issue = 2 | pages = 384–90 | date = Oct 2003 | pmid = 14521922 | doi = 10.1016/j.bbrc.2003.08.145 }}
*{{cite journal  | author=Inui S, Lee YF, Chang E, ''et al.'' |title=Differential and bi-directional regulation between TR2/TR4 orphan nuclear receptors and a specific ligand mediated-peroxisome proliferator-activated receptor alpha in human HaCaT keratinocytes. |journal=J. Dermatol. Sci. |volume=31 |issue= 1 |pages= 65-71 |year= 2003 |pmid= 12615366 |doi= }}
* {{cite journal | vauthors = Lin YL, Wang YH, Lee HJ | title = Transcriptional regulation of the human TR2 orphan receptor gene by nuclear factor 1-A | journal = Biochemical and Biophysical Research Communications | volume = 350 | issue = 2 | pages = 430–6 | date = Nov 2006 | pmid = 17010934 | doi = 10.1016/j.bbrc.2006.09.061 }}
*{{cite journal | author=Franco PJ, Li G, Wei LN |title=Interaction of nuclear receptor zinc finger DNA binding domains with histone deacetylase. |journal=Mol. Cell. Endocrinol. |volume=206 |issue= 1-2 |pages= 1-12 |year= 2004 |pmid= 12943985 |doi= }}
*{{cite journal | author=Mu X, Chang C |title=TR2 orphan receptor functions as negative modulator for androgen receptor in prostate cancer cells PC-3. |journal=Prostate |volume=57 |issue= 2 |pages= 129-33 |year= 2003 |pmid= 12949936 |doi= 10.1002/pros.10282 }}
*{{cite journal | author=Li G, Franco PJ, Wei LN |title=Identification of histone deacetylase-3 domains that interact with the orphan nuclear receptor TR2. |journal=Biochem. Biophys. Res. Commun. |volume=310 |issue= 2 |pages= 384-90 |year= 2003 |pmid= 14521922 |doi= }}
*{{cite journal | author=Lin YL, Wang YH, Lee HJ |title=Transcriptional regulation of the human TR2 orphan receptor gene by nuclear factor 1-A. |journal=Biochem. Biophys. Res. Commun. |volume=350 |issue= 2 |pages= 430-6 |year= 2006 |pmid= 17010934 |doi= 10.1016/j.bbrc.2006.09.061 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{gene-12-stub}}
{{Transcription factors}}
{{Transcription factors|g2}}
[[Category:Intracellular receptors]]
[[Category:Intracellular receptors]]
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}

Latest revision as of 16:54, 15 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
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Ensembl

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

The testicular receptor 2 (TR2) also known as NR2C1 (nuclear receptor subfamily 2, group C, member 1) is protein that in humans is encoded by the NR2C1 gene.[1][2] TR2 is a member of the nuclear receptor family of transcription factors.

Interactions

Testicular receptor 2 has been shown to interact with:

See also

References

  1. ↑ "Entrez Gene: NR2C1 nuclear receptor subfamily 2, group C, member 1".
  2. ↑ Chang C, Kokontis J, Acakpo-Satchivi L, Liao S, Takeda H, Chang Y (Dec 1989). "Molecular cloning of new human TR2 receptors: a class of steroid receptor with multiple ligand-binding domains". Biochemical and Biophysical Research Communications. 165 (2): 735–41. doi:10.1016/S0006-291X(89)80028-2. PMID 2597158.
  3. ↑ Mu X, Chang C (Oct 2003). "TR2 orphan receptor functions as negative modulator for androgen receptor in prostate cancer cells PC-3". The Prostate. 57 (2): 129–33. doi:10.1002/pros.10282. PMID 12949936.
  4. ↑ Hu YC, Shyr CR, Che W, Mu XM, Kim E, Chang C (Sep 2002). "Suppression of estrogen receptor-mediated transcription and cell growth by interaction with TR2 orphan receptor". The Journal of Biological Chemistry. 277 (37): 33571–9. doi:10.1074/jbc.M203531200. PMID 12093804.
  5. ↑ Li G, Franco PJ, Wei LN (Oct 2003). "Identification of histone deacetylase-3 domains that interact with the orphan nuclear receptor TR2". Biochemical and Biophysical Research Communications. 310 (2): 384–90. doi:10.1016/j.bbrc.2003.08.145. PMID 14521922.
  6. ↑ 6.0 6.1 Franco PJ, Li G, Wei LN (Aug 2003). "Interaction of nuclear receptor zinc finger DNA binding domains with histone deacetylase". Molecular and Cellular Endocrinology. 206 (1–2): 1–12. doi:10.1016/S0303-7207(03)00254-5. PMID 12943985.
  7. ↑ 7.0 7.1 Franco PJ, Farooqui M, Seto E, Wei LN (Aug 2001). "The orphan nuclear receptor TR2 interacts directly with both class I and class II histone deacetylases". Molecular Endocrinology. 15 (8): 1318–28. doi:10.1210/mend.15.8.0682. PMID 11463856.

Further reading

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