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*{{cite journal  | vauthors=Martin J, Halenbeck R, Kaufmann J |title=Human transcription factor hTAF(II)150 (CIF150) is involved in transcriptional regulation of cell cycle progression. |journal=Mol. Cell. Biol. |volume=19 |issue= 8 |pages= 5548–56 |year= 1999 |pmid= 10409744 |doi=  | pmc=84407  }}
*{{cite journal  | vauthors=Martin J, Halenbeck R, Kaufmann J |title=Human transcription factor hTAF(II)150 (CIF150) is involved in transcriptional regulation of cell cycle progression. |journal=Mol. Cell. Biol. |volume=19 |issue= 8 |pages= 5548–56 |year= 1999 |pmid= 10409744 |doi=  | pmc=84407  }}
*{{cite journal  | vauthors=Chalkley GE, Verrijzer CP |title=DNA binding site selection by RNA polymerase II TAFs: a TAF(II)250-TAF(II)150 complex recognizes the initiator. |journal=EMBO J. |volume=18 |issue= 17 |pages= 4835–45 |year= 1999 |pmid= 10469661 |doi= 10.1093/emboj/18.17.4835  | pmc=1171555 }}
*{{cite journal  | vauthors=Chalkley GE, Verrijzer CP |title=DNA binding site selection by RNA polymerase II TAFs: a TAF(II)250-TAF(II)150 complex recognizes the initiator. |journal=EMBO J. |volume=18 |issue= 17 |pages= 4835–45 |year= 1999 |pmid= 10469661 |doi= 10.1093/emboj/18.17.4835  | pmc=1171555 }}
*{{cite journal  |vauthors=Suzuki Y, Tsunoda T, Sese J, etal |title=Identification and characterization of the potential promoter regions of 1031 kinds of human genes. |journal=Genome Res. |volume=11 |issue= 5 |pages= 677–84 |year= 2001 |pmid= 11337467 |doi= 10.1101/gr.164001  | pmc=311086 }}
*{{cite journal  |vauthors=Suzuki Y, Tsunoda T, Sese J, etal |title=Identification and characterization of the potential promoter regions of 1031 kinds of human genes. |journal=Genome Res. |volume=11 |issue= 5 |pages= 677–84 |year= 2001 |pmid= 11337467 |doi=   10.1101/gr.gr-1640r| pmc=311086 }}
*{{cite journal  |vauthors=Brand M, Moggs JG, Oulad-Abdelghani M, etal |title=UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation. |journal=EMBO J. |volume=20 |issue= 12 |pages= 3187–96 |year= 2001 |pmid= 11406595 |doi= 10.1093/emboj/20.12.3187  | pmc=150203 }}
*{{cite journal  |vauthors=Brand M, Moggs JG, Oulad-Abdelghani M, etal |title=UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation. |journal=EMBO J. |volume=20 |issue= 12 |pages= 3187–96 |year= 2001 |pmid= 11406595 |doi= 10.1093/emboj/20.12.3187  | pmc=150203 }}
*{{cite journal  |vauthors=Martinez E, Palhan VB, Tjernberg A, etal |title=Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo. |journal=Mol. Cell. Biol. |volume=21 |issue= 20 |pages= 6782–95 |year= 2001 |pmid= 11564863 |doi= 10.1128/MCB.21.20.6782-6795.2001  | pmc=99856 }}
*{{cite journal  |vauthors=Martinez E, Palhan VB, Tjernberg A, etal |title=Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo. |journal=Mol. Cell. Biol. |volume=21 |issue= 20 |pages= 6782–95 |year= 2001 |pmid= 11564863 |doi= 10.1128/MCB.21.20.6782-6795.2001  | pmc=99856 }}

Latest revision as of 08:40, 10 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Transcription initiation factor TFIID subunit 2 is a protein that in humans is encoded by the TAF2 gene.[1][2][3]

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the larger subunits of TFIID that is stably associated with the TFIID complex. It contributes to interactions at and downstream of the transcription initiation site, interactions that help determine transcription complex response to activators.[3]

References

  1. Martinez E, Ge H, Tao Y, Yuan CX, Palhan V, Roeder RG (Nov 1998). "Novel cofactors and TFIIA mediate functional core promoter selectivity by the human TAFII150-containing TFIID complex". Mol Cell Biol. 18 (11): 6571–83. PMC 109242. PMID 9774672.
  2. Kaufmann J, Ahrens K, Koop R, Smale ST, Muller R (Jan 1998). "CIF150, a human cofactor for transcription factor IID-dependent initiator function". Mol Cell Biol. 18 (1): 233–9. PMC 121482. PMID 9418870.
  3. 3.0 3.1 "Entrez Gene: TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa".

Further reading

External links